SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_024557
Gene Symbol:	RIC3
Description:	Homo sapiens resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 2, mRNA.
Gene Location:	chr11(-):8127596-8190590
Browse Associations

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8106644A>G			COSN8874106		AOCS-134-3-9		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3917	ttaggGTCCGAGCaagccc	0	GCUCGGAC	m8a	Created	no TS	-0.176000	-1.480000
hsa-miR-423-3p	ttagggtCCGAGCaagccc	0	AGCUCGGU	m6b	Created	no TS	-0.191000	-6.000000
hsa-miR-4535	ttagGGTCCAagcaagccc	2	GUGGACCU	m6b	Disrupted	-0.310000	-0.178000	1.060000
hsa-miR-4776-5p	ttagGGTCCAagcaagccc	2	GUGGACCA	m6b	Disrupted	-0.221000	-0.083000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8107044C>G			COSN7286949		8044436		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-103a-2-5p	ctcagAGAAGCagtttccc	0	AGCUUCUU	m6b	Created	no TS	-0.008000	No effect
hsa-miR-2117	ctcAGAGAACcagtttccc	4	UGUUCUCU	m7b	(m7b->m6c)	-0.330000	-0.304000	No effect
hsa-miR-548av-3p	ctcagagaaGCAGTTTccc	4	AAAACUGC	m7b	(m6b->m7b)	0.103000	0.094000	0.010000
hsa-miR-582-3p	ctcagagaACCAGTTtccc	4	UAACUGGU	m7b	Disrupted	-0.038000	no TS	0.070000
hsa-miR-942	ctcAGAGAAGcagtttccc	3	UCUUCUCU	m7b	(m6c->m7b)	-0.142000	-0.115000	0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8107384C>T			COSN7286953		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5689	tccTGTATGCgctatttcc	1	AGCAUACA	m7b	(m7b->m6c)	0.027000	no TS	0.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8108275G>A			COSN8874118		AOCS-088-3-8		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-129-5p	ctcttgGCAAAAAGagttg	2	CUUUUUGC	m8a	Created	0.104000	0.269000	0.040000
hsa-miR-130b-5p	ctcttggcaGAAAGAGTtg	0	ACUCUUUC	m8a	(m8a->m7a)	0.072000	no TS	No effect
hsa-miR-192-3p	ctcTTGGCAGaaagagttg	0	CUGCCAAU	m7a	(m7a->m6b)	no TS	0.006000	No effect
hsa-miR-4727-5p	ctctTGGCAGAaagagttg	6	AUCUGCCA	m7b	Disrupted	-0.046000	0.007000	0.030000
hsa-miR-4769-3p	ctctTGGCAGAaagagttg	6	UCUGCCAU	m7a	Disrupted	-0.019000	0.001000	5.150000
hsa-miR-4776-3p	ctctTGGCAAaaagagttg	0	CUUGCCAU	m6b	Created	no TS	0.011000	-0.080000
hsa-miR-5001-3p	ctcttGGCAGAAagagttg	3	UUCUGCCU	m7a	Disrupted	0.094000	0.108000	0.010000
hsa-miR-544a	ctcttgGCAGAAagagttg	0	AUUCUGCA	m6b	Disrupted	0.048000	no TS	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8108323T>A			COSN7286961		8061178		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273e	cttgaggCAAGCAAagaac	3	UUGCUUGA	m7a	Created	-0.031000	0.012000	-0.130000
hsa-miR-3152-5p	cttGAGGCAAgcaaagaac	1	AUUGCCUC	m7b	(m6c->m7b)	0.044000	0.060000	0.370000
hsa-miR-3680-3p	cttgaggcATGCAAAgaac	1	UUUUGCAU	m7b	Disrupted	0.161000	no TS	0.170000
hsa-miR-4327	cttgagGCAAGCaaagaac	0	GGCUUGCA	m6b	Created	no TS	-0.024000	No effect
hsa-miR-4666b	cttgaggCATGCAAagaac	1	UUGCAUGU	m7a	Disrupted	0.045000	no TS	0.080000
hsa-miR-5011-3p	cttgaggCATGCAaagaac	1	GUGCAUGG	m6b	Disrupted	0.044000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8109020T>C			COSN14855373		LP6007438-DNA_A01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3545-3p	aatgCAGTTCAAaatatac	0	UUGAACUG	m8a	Created	no TS	0.014000	No effect
hsa-miR-548av-3p	aatGCAGTTTaaaatatac	4	AAAACUGC	m7b	(m7b->m6c)	0.103000	0.146000	0.550000
hsa-miR-548g-3p	aatgCAGTTTaaaatatac	12	AAAACUGU	m6b	Disrupted	0.186000	0.134000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8109343G>A			COSN195642		PD4198a		[NS][NS][NS][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3545-3p	tgagAGTTCAAagagggca	0	UUGAACUG	m7a	Created	no TS	0.065000	No effect
hsa-miR-877-3p	tgagagttcGAAGAGGgca	2	UCCUCUUC	m7b	(m7b->m6b)	0.031000	no TS	No effect
hsa-miR-3545-3p	tgagAGTTCAAagagggca	0	UUGAACUG	m7a	Created	no TS	0.065	No effect
hsa-miR-877-3p	tgagagttcGAAGAGGgca	0	UCCUCUUC	m7b	(m7b->m6b)	0.031	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8110082C>T			COSN1545707		RK003_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-194-3p	ggaagactCCCACTGatct	4	CCAGUGGG	m7b	Disrupted	-0.286000	no TS	4.490000
hsa-miR-4276	ggaagactcTCACTGAtct	0	CUCAGUGA	m7b	(m6b->m7b)	no TS	-0.043000	No effect
hsa-miR-4294	ggaAGACTCCCactgatct	5	GGGAGUCU	m8a	Disrupted	-0.406000	-0.303000	0.010000
hsa-miR-5007-5p	ggaAGACTCTcactgatct	2	UAGAGUCU	m7b	(m6c->m7b)	-0.077000	-0.166000	No effect
hsa-miR-5190	ggaagactcTCACTGatct	0	CCAGUGAC	m6b	Created	no TS	-0.051000	-0.010000
hsa-miR-5693	ggaagactcCCACTGatct	4	GCAGUGGC	m6b	Disrupted	-0.073000	no TS	0.010000
hsa-miR-924	ggAAGACTCTcactgatct	5	AGAGUCUU	m8a	(m7b->m8a)	-0.095000	-0.123000	0.060000
hsa-miR-194-3p	ggaagactCCCACTGatct	4	CCAGUGGG	m7b	Disrupted	-0.286000	no TS	4.490000
hsa-miR-4276	ggaagactcTCACTGAtct	0	CUCAGUGA	m7b	(m6b->m7b)	no TS	-0.043000	No effect
hsa-miR-4294	ggaAGACTCCCactgatct	5	GGGAGUCU	m8a	Disrupted	-0.406000	-0.303000	0.010000
hsa-miR-5007-5p	ggaAGACTCTcactgatct	2	UAGAGUCU	m7b	(m6c->m7b)	-0.077000	-0.166000	No effect
hsa-miR-5190	ggaagactcTCACTGatct	0	CCAGUGAC	m6b	Created	no TS	-0.051000	-0.010000
hsa-miR-5693	ggaagactcCCACTGatct	4	GCAGUGGC	m6b	Disrupted	-0.073000	no TS	0.010000
hsa-miR-924	ggAAGACTCTcactgatct	5	AGAGUCUU	m8a	(m7b->m8a)	-0.095000	-0.123000	0.060000
hsa-miR-194-3p	ggaagactCCCACTGatct	4	CCAGUGGG	m7b	Disrupted	-0.286000	no TS	4.490000
hsa-miR-4276	ggaagactcTCACTGAtct	0	CUCAGUGA	m7b	(m6b->m7b)	no TS	-0.043000	No effect
hsa-miR-4294	ggaAGACTCCCactgatct	5	GGGAGUCU	m8a	Disrupted	-0.406000	-0.303000	0.010000
hsa-miR-5007-5p	ggaAGACTCTcactgatct	2	UAGAGUCU	m7b	(m6c->m7b)	-0.077000	-0.166000	No effect
hsa-miR-5190	ggaagactcTCACTGatct	0	CCAGUGAC	m6b	Created	no TS	-0.051000	-0.010000
hsa-miR-5693	ggaagactcCCACTGatct	4	GCAGUGGC	m6b	Disrupted	-0.073000	no TS	0.010000
hsa-miR-924	ggAAGACTCTcactgatct	5	AGAGUCUU	m8a	(m7b->m8a)	-0.095000	-0.123000	0.060000
hsa-miR-194-3p	ggaagactCCCACTGatct	0	CCAGUGGG	m7b	Disrupted	-0.286	no TS	4.49
hsa-miR-4276	ggaagactcTCACTGAtct	0	CUCAGUGA	m7b	(m6b->m7b)	no TS	-0.043	No effect
hsa-miR-4294	ggaAGACTCCCactgatct	0	GGGAGUCU	m8a	Disrupted	-0.406	-0.303	0.01
hsa-miR-5007-5p	ggaAGACTCTcactgatct	0	UAGAGUCU	m7b	(m6c->m7b)	-0.077	-0.166	No effect
hsa-miR-5190	ggaagactcTCACTGatct	0	CCAGUGAC	m6b	Created	no TS	-0.051	-0.01
hsa-miR-5693	ggaagactcCCACTGatct	0	GCAGUGGC	m6b	Disrupted	-0.073	no TS	0.01
hsa-miR-924	ggAAGACTCTcactgatct	0	AGAGUCUU	m8a	(m7b->m8a)	-0.095	-0.123	0.06

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8110603C>T			COSN8584790		951_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-128	ctttcttCACTGTGttcaa	4	UCACAGUG	m7b	Disrupted	-0.054000	0.150000	0.730000
hsa-miR-3681-3p	ctttcttCACTGTGTtcaa	4	ACACAGUG	m8a	Disrupted	-0.034000	0.161000	0.270000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.8110608C>T			COSN8309473		TCGA-AO-A03M-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-106a-5p	ctGCACTTTTttcactgtg	1	AAAAGUGC	m8a	(m7b->m8a)	-0.114000	-0.142000	-0.090000
hsa-miR-3185	ctgcactTTCTTCactgtg	2	AGAAGAAG	m6b	Disrupted	0.122000	0.136000	No effect
hsa-miR-526b-3p	ctGCACTTTCttcactgtg	1	GAAAGUGC	m8a	(m8a->m7b)	-0.095000	-0.123000	-0.020000
hsa-miR-548t-5p	ctgCACTTTTttcactgtg	0	CAAAAGUG	m7b	(m6c->m7b)	no TS	-0.026000	No effect

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
8106695	rs202243860	A	A	hsa-miR-129-5p hsa-miR-4423-5p hsa-miR-6501-5p hsa-miR-744-3p	2 0 0 0	ggcaaCAAAAAAa GGCAACAaaaaaa GGCAACAaaaaaa GGCAACAAaaaaa	Disrupted Disrupted Disrupted Disrupted	N N N N	0.001 -0.1 -0.107 -0.206
8106695	rs202243860	A	C	hsa-miR-656-5p hsa-miR-659-3p	0	GGCAACCAaaaaa ggcAACCAAAaaa	Created Created	N N	-0.324 0.007
8108270	rs7944737	A	A	hsa-miR-130b-5p	1	aGAAAGAGttgtt	Disrupted	N	0.072
8108270	rs7944737	A
8108640	rs190732514	A	A	hsa-miR-4768-5p hsa-miR-6809-3p hsa-miR-6833-3p	6 6 6	AGAGAAAcatgag AGAGAAAcatgag AGAGAAAcatgag	Disrupted Disrupted Disrupted	N N N	0.138 0.137 0.135
8108640	rs190732514	A	G	hsa-miR-103a-2-5p hsa-miR-942-5p	3 6	agAGAAGCAtgag AGAGAAGcatgag	Created Created	N N	0.055 0.139
8110079	rs150130872	C	C	hsa-miR-1233-5p hsa-miR-194-3p hsa-miR-5094 hsa-miR-5693 hsa-miR-6778-5p	3 4 3 4 3	CTCCCACtgatct ctCCCACTGAtct ctccCACTGATct ctcCCACTGAtct CTCCCACtgatct	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.144 -0.286 -0.041 -0.073 -0.144
8110079	rs150130872	C	T	hsa-miR-6871-5p	3	CTCCCATtgatct	Created	N	-0.137
8110184	rs59468221	A	A	hsa-miR-200c-5p hsa-miR-5007-5p hsa-miR-550a-3p hsa-miR-924	5 2 5 2	gGTAAGACtctgc ggtaAGACTCTgc gGTAAGACtctgc ggtAAGACTCtgc	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.026 -0.077 -0.054 -0.075
8110184	rs59468221	A
8110393	rs1133972	G	G	hsa-miR-125a-5p hsa-miR-125b-5p hsa-miR-210-5p hsa-miR-4319 hsa-miR-4749-3p	7 7 4 7 4	aCTCAGGGgcaaa aCTCAGGGgcaaa actCAGGGGCAaa aCTCAGGGgcaaa actcAGGGGCAaa	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.173 -0.164 -0.456 -0.192 -0.202
8110393	rs1133972	G	T	hsa-miR-181a-2-3p hsa-miR-3064-3p hsa-miR-4252 hsa-miR-4715-3p hsa-miR-4776-3p	4 5 4 5 6	acTCAGTGGcaaa actcaGTGGCAAa actCAGTGGCAaa actcaGTGGCAAa actcagTGGCAAA	Created Created Created Created Created	N N N N N	-0.142 -0.129 -0.368 -0.128 -0.108

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser