SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001135109
Gene Symbol: RIC3
Description: Homo sapiens resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 2, mRNA.
Gene Location: chr11(-):8127596-8190590
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr11:g.8106644A>G COSN8874106 AOCS-134-3-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3917 ttaggGTCCGAGCaagccc
 0 GCUCGGAC m8a Created no TS -0.176000 -1.480000
hsa-miR-423-3p ttagggtCCGAGCaagccc
 0 AGCUCGGU m6b Created no TS -0.191000 -6.000000
hsa-miR-4535 ttagGGTCCAagcaagccc
 2
 GUGGACCU m6b Disrupted -0.310000 -0.178000 1.060000
hsa-miR-4776-5p ttagGGTCCAagcaagccc
 2
 GUGGACCA m6b Disrupted -0.221000 -0.083000 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8107044C>G COSN7286949 8044436 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-2-5p ctcagAGAAGCagtttccc
 0 AGCUUCUU m6b Created no TS -0.008000 No effect
hsa-miR-2117 ctcAGAGAACcagtttccc
 4
 UGUUCUCU m7b (m7b->m6c) -0.330000 -0.304000 No effect
hsa-miR-548av-3p ctcagagaaGCAGTTTccc
 4
 AAAACUGC m7b (m6b->m7b) 0.103000 0.094000 0.010000
hsa-miR-582-3p ctcagagaACCAGTTtccc
 4
 UAACUGGU m7b Disrupted -0.038000 no TS 0.070000
hsa-miR-942 ctcAGAGAAGcagtttccc
 3
 UCUUCUCU m7b (m6c->m7b) -0.142000 -0.115000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8107384C>T COSN7286953 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5689 tccTGTATGCgctatttcc
 1
 AGCAUACA m7b (m7b->m6c) 0.027000 no TS 0.210000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8108275G>A COSN8874118 AOCS-088-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-5p ctcttgGCAAAAAGagttg
 2
 CUUUUUGC m8a Created 0.104000 0.269000 0.040000
hsa-miR-130b-5p ctcttggcaGAAAGAGTtg
 0 ACUCUUUC m8a (m8a->m7a) 0.072000 no TS No effect
hsa-miR-192-3p ctcTTGGCAGaaagagttg
 0 CUGCCAAU m7a (m7a->m6b) no TS 0.006000 No effect
hsa-miR-4727-5p ctctTGGCAGAaagagttg
 6
 AUCUGCCA m7b Disrupted -0.046000 0.007000 0.030000
hsa-miR-4769-3p ctctTGGCAGAaagagttg
 6
 UCUGCCAU m7a Disrupted -0.019000 0.001000 5.150000
hsa-miR-4776-3p ctctTGGCAAaaagagttg
 0 CUUGCCAU m6b Created no TS 0.011000 -0.080000
hsa-miR-5001-3p ctcttGGCAGAAagagttg
 3
 UUCUGCCU m7a Disrupted 0.094000 0.108000 0.010000
hsa-miR-544a ctcttgGCAGAAagagttg
 0 AUUCUGCA m6b Disrupted 0.048000 no TS 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8108323T>A COSN7286961 8061178 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273e cttgaggCAAGCAAagaac
 3
 UUGCUUGA m7a Created -0.031000 0.012000 -0.130000
hsa-miR-3152-5p cttGAGGCAAgcaaagaac
 1
 AUUGCCUC m7b (m6c->m7b) 0.044000 0.060000 0.370000
hsa-miR-3680-3p cttgaggcATGCAAAgaac
 1
 UUUUGCAU m7b Disrupted 0.161000 no TS 0.170000
hsa-miR-4327 cttgagGCAAGCaaagaac
 0 GGCUUGCA m6b Created no TS -0.024000 No effect
hsa-miR-4666b cttgaggCATGCAAagaac
 1
 UUGCAUGU m7a Disrupted 0.045000 no TS 0.080000
hsa-miR-5011-3p cttgaggCATGCAaagaac
 1
 GUGCAUGG m6b Disrupted 0.044000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8109020T>C COSN14855373 LP6007438-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3545-3p aatgCAGTTCAAaatatac
 0 UUGAACUG m8a Created no TS 0.014000 No effect
hsa-miR-548av-3p aatGCAGTTTaaaatatac
 4
 AAAACUGC m7b (m7b->m6c) 0.103000 0.146000 0.550000
hsa-miR-548g-3p aatgCAGTTTaaaatatac
 12
 AAAACUGU m6b Disrupted 0.186000 0.134000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8109343G>A COSN195642 PD4198a [NS][NS][NS][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3545-3p tgagAGTTCAAagagggca
 0 UUGAACUG m7a Created no TS 0.065000 No effect
hsa-miR-877-3p tgagagttcGAAGAGGgca
 2
 UCCUCUUC m7b (m7b->m6b) 0.031000 no TS No effect
hsa-miR-3545-3p tgagAGTTCAAagagggca
 0 UUGAACUG m7a Created no TS 0.065 No effect
hsa-miR-877-3p tgagagttcGAAGAGGgca
 0 UCCUCUUC m7b (m7b->m6b) 0.031 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8110082C>T COSN1545707 RK003_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-194-3p ggaagactCCCACTGatct
 4
 CCAGUGGG m7b Disrupted -0.286000 no TS 4.490000
hsa-miR-4276 ggaagactcTCACTGAtct
 0 CUCAGUGA m7b (m6b->m7b) no TS -0.043000 No effect
hsa-miR-4294 ggaAGACTCCCactgatct
 5
 GGGAGUCU m8a Disrupted -0.406000 -0.303000 0.010000
hsa-miR-5007-5p ggaAGACTCTcactgatct
 2
 UAGAGUCU m7b (m6c->m7b) -0.077000 -0.166000 No effect
hsa-miR-5190 ggaagactcTCACTGatct
 0 CCAGUGAC m6b Created no TS -0.051000 -0.010000
hsa-miR-5693 ggaagactcCCACTGatct
 4
 GCAGUGGC m6b Disrupted -0.073000 no TS 0.010000
hsa-miR-924 ggAAGACTCTcactgatct
 5
 AGAGUCUU m8a (m7b->m8a) -0.095000 -0.123000 0.060000
hsa-miR-194-3p ggaagactCCCACTGatct
 4
 CCAGUGGG m7b Disrupted -0.286000 no TS 4.490000
hsa-miR-4276 ggaagactcTCACTGAtct
 0 CUCAGUGA m7b (m6b->m7b) no TS -0.043000 No effect
hsa-miR-4294 ggaAGACTCCCactgatct
 5
 GGGAGUCU m8a Disrupted -0.406000 -0.303000 0.010000
hsa-miR-5007-5p ggaAGACTCTcactgatct
 2
 UAGAGUCU m7b (m6c->m7b) -0.077000 -0.166000 No effect
hsa-miR-5190 ggaagactcTCACTGatct
 0 CCAGUGAC m6b Created no TS -0.051000 -0.010000
hsa-miR-5693 ggaagactcCCACTGatct
 4
 GCAGUGGC m6b Disrupted -0.073000 no TS 0.010000
hsa-miR-924 ggAAGACTCTcactgatct
 5
 AGAGUCUU m8a (m7b->m8a) -0.095000 -0.123000 0.060000
hsa-miR-194-3p ggaagactCCCACTGatct
 4
 CCAGUGGG m7b Disrupted -0.286000 no TS 4.490000
hsa-miR-4276 ggaagactcTCACTGAtct
 0 CUCAGUGA m7b (m6b->m7b) no TS -0.043000 No effect
hsa-miR-4294 ggaAGACTCCCactgatct
 5
 GGGAGUCU m8a Disrupted -0.406000 -0.303000 0.010000
hsa-miR-5007-5p ggaAGACTCTcactgatct
 2
 UAGAGUCU m7b (m6c->m7b) -0.077000 -0.166000 No effect
hsa-miR-5190 ggaagactcTCACTGatct
 0 CCAGUGAC m6b Created no TS -0.051000 -0.010000
hsa-miR-5693 ggaagactcCCACTGatct
 4
 GCAGUGGC m6b Disrupted -0.073000 no TS 0.010000
hsa-miR-924 ggAAGACTCTcactgatct
 5
 AGAGUCUU m8a (m7b->m8a) -0.095000 -0.123000 0.060000
hsa-miR-194-3p ggaagactCCCACTGatct
 0 CCAGUGGG m7b Disrupted -0.286 no TS 4.49
hsa-miR-4276 ggaagactcTCACTGAtct
 0 CUCAGUGA m7b (m6b->m7b) no TS -0.043 No effect
hsa-miR-4294 ggaAGACTCCCactgatct
 0 GGGAGUCU m8a Disrupted -0.406 -0.303 0.01
hsa-miR-5007-5p ggaAGACTCTcactgatct
 0 UAGAGUCU m7b (m6c->m7b) -0.077 -0.166 No effect
hsa-miR-5190 ggaagactcTCACTGatct
 0 CCAGUGAC m6b Created no TS -0.051 -0.01
hsa-miR-5693 ggaagactcCCACTGatct
 0 GCAGUGGC m6b Disrupted -0.073 no TS 0.01
hsa-miR-924 ggAAGACTCTcactgatct
 0 AGAGUCUU m8a (m7b->m8a) -0.095 -0.123 0.06

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8110603C>T COSN8584790 951_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-128 ctttcttCACTGTGttcaa
 4
 UCACAGUG m7b Disrupted -0.054000 0.150000 0.730000
hsa-miR-3681-3p ctttcttCACTGTGTtcaa
 4
 ACACAGUG m8a Disrupted -0.034000 0.161000 0.270000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.8110608C>T COSN8309473 TCGA-AO-A03M-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p ctGCACTTTTttcactgtg
 1
 AAAAGUGC m8a (m7b->m8a) -0.114000 -0.142000 -0.090000
hsa-miR-3185 ctgcactTTCTTCactgtg
 2
 AGAAGAAG m6b Disrupted 0.122000 0.136000 No effect
hsa-miR-526b-3p ctGCACTTTCttcactgtg
 1
 GAAAGUGC m8a (m8a->m7b) -0.095000 -0.123000 -0.020000
hsa-miR-548t-5p ctgCACTTTTttcactgtg
 0 CAAAAGUG m7b (m6c->m7b) no TS -0.026000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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