SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_020975
Gene Symbol: RET
Description: Homo sapiens ret proto-oncogene (RET), transcript variant 4, mRNA.
Gene Location: chr10(+):43572516-43625797
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr10:g.43128312A>G cosmic_v64_1760532 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4310 ggaagaaacATGCTGagaa
 0 GCAGCAUU m6b Disrupted -0.312 -0.178 0.01

Mutation Mutation ID Sample Name Cancer Type
chr10:g.43128432T>C COSN8640078 J10_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548aa aggTGGTTTTacttctgat
 0 AAAAACCA m7b (m7b->m6b) -0.310000 -0.201000 1.830000
hsa-miR-548ao-5p aggtggttTTACTTCTgat
 0 AGAAGUAA m8a Disrupted -0.126000 no TS 0.130000
hsa-miR-548ap-3p aggTGGTTTTacttctgat
 0 AAAAACCA m7b (m7b->m6b) -0.310000 -0.201000 0.330000
hsa-miR-548at-3p aggtGGTTTTacttctgat
 0 CAAAACCG m6b Disrupted -0.044000 no TS 0.110000
hsa-miR-548ax aggtggttTTACTTCTgat
 0 AGAAGUAA m8a Disrupted -0.126000 no TS 0.400000
hsa-miR-548t-3p aggTGGTTTTacttctgat
 0 AAAAACCA m7b (m7b->m6b) -0.310000 -0.201000 1.830000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.43128657G>A COSN6970725 8031867 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3688-5p ctagTTGCCACcaaacaag
 2
 AGUGGCAA m7b Created -0.121000 -0.313000 -0.020000
hsa-miR-4467 ctagttGCCGCCAaacaag
 3
 UGGCGGCG m7a Disrupted -0.296000 no TS 0.010000
hsa-miR-4730 ctagttgCCGCCAaacaag
 3
 CUGGCGGA m6b Disrupted -0.272000 no TS 6.320000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.43128731G>A COSN8640079 1848_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-154-5p ggccctgATAACCTgtcct
 4
 UAGGUUAU m7b Created -0.292000 -0.320000 No effect
hsa-miR-374a-3p ggccCTGATAAcctgtcct
 0 CUUAUCAG m7b Created no TS 0.013000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr10:g.43128845G>A cosmic_v64_1760527 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.43129858C>T COSN8185424 PCSI_0218_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3200-5p gctgttttTCAGATacact
 2
 AAUCUGAG m6b Disrupted -0.134000 -0.078000 0.080000
hsa-miR-4799-5p gctgtttTTTAGATacact
 0 AUCUAAAU m7a Created NA NA -7.367000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.43130168T>C cosmic_v64_1760525 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3688-3p ctggaaTTTCCATAcacgt
 0 UAUGGAAA m8a Created no TS -0.187 -0.07
hsa-miR-5093 ctggaATTTCCatacacgt
 0 AGGAAAUG m6b Created no TS -0.044 -0.02

Mutation Mutation ID Sample Name Cancer Type
chr10:g.43130235T>C cosmic_v64_1760525 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3660 atCTGTCAGTtattaaaat
 0 ACUGACAG m8a (m8a->m7a) -0.31 -0.283 No effect
hsa-miR-4526 atCTGTCAGCtattaaaat
 0 GCUGACAG m8a (m7a->m8a) -0.319 -0.292 No effect
hsa-miR-633 atctgtcagCTATTAaaat
 0 CUAAUAGU m6b Created no TS -0.076 -0.84
hsa-miR-888-3p atcTGTCAGTtattaaaat
 8
 GACUGACA m7b (m7b->m6b) -0.266 no TS 0.01

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
43128657 rs3026782 G G hsa-miR-4467
hsa-miR-4730
hsa-miR-6770-3p
3
3
3
 gttGCCGCCAaac
gttgCCGCCAAac
gttGCCGCCAAac
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.296
-0.272
-0.608
A hsa-miR-196a-3p
hsa-miR-3688-5p
5
4
 GTTGCCAccaaac
gTTGCCACcaaac
 Created
Created
N
N
 -0.141
-0.192
43129860 rs76759170 G G hsa-miR-3200-5p
hsa-miR-4766-5p
10
7
 tttTCAGATAcac
tTTTCAGAtacac
 Disrupted
Disrupted
N
N
 -0.056
-0.003
A hsa-miR-223-5p
hsa-miR-510-3p
14
7
 ttttcaAATACAC
tTTTCAAAtacac
 Created
Created
N
N
 -0.122
0.041
43129913 rs117119161 G G hsa-miR-548aa
hsa-miR-548ap-3p
hsa-miR-548t-3p
hsa-miR-570-3p
6
8
7
22
 ctttTGGTTTTca
ctttTGGTTTTca
ctttTGGTTTTca
cttttgGTTTTCA
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.13
-0.13
-0.13
-0.026
C hsa-miR-548aj-5p
hsa-miR-548e-5p
hsa-miR-548f-5p
hsa-miR-548g-5p
hsa-miR-548p
hsa-miR-548x-5p
5
8
5
5
5
5
 CTTTTGCttttca
ctttTGCTTTTca
CTTTTGCttttca
CTTTTGCttttca
cTTTTGCTtttca
CTTTTGCttttca
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.159
-0.107
-0.159
-0.159
-0.082
-0.159
43129923 rs139925563 A A hsa-miR-3200-5p
2
 TCAGATAtgctta
 Disrupted
N
 -0.078

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