SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_018715
Gene Symbol: RCC2
Description: Homo sapiens regulator of chromosome condensation 2 (RCC2), transcript variant 2, mRNA.
Gene Location: chr1(-):17733250-17766220
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr1:g.17407068A>C COSN6430621 CHC322T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1305 agaTTGAAAAatgggcttc
1
UUUUCAAC m7a (m7a->m6b) 0.036000 no TS 0.230000
hsa-miR-4641 agattgaaaCATGGGCttc
0 UGCCCAUG m7b (m6b->m7b) no TS -0.283000 -1.810000
hsa-miR-4716-5p agattgaAACATGGgcttc
1
UCCAUGUU m7b Created -0.067000 -0.182000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.17408329A>G COSN6009877 RK175_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4719 aacATTTGTGtcagttgag
0 UCACAAAU m7b (m6c->m7b) no TS 0.098000 -4.220000
hsa-miR-642a-3p aacattTGTGTCagttgag
0 AGACACAU m6b Created no TS -0.023000 No effect
hsa-miR-642b-3p aacattTGTGTCagttgag
0 AGACACAU m6b Created no TS -0.027000 -0.010000
hsa-miR-888-3p aacatttgTGTCAGTtgag
0 GACUGACA m7b Created no TS -0.046000 -0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
17407068 rs7191 A A hsa-miR-1305
hsa-miR-153-5p
hsa-miR-335-3p
1
2
1
TTGAAAAatgggc
ttgAAAAATGggc
tTGAAAAAtgggc
Disrupted
Disrupted
Disrupted
N
N
N
0.036
0.091
0.051
C hsa-miR-4641
hsa-miR-4716-5p
11
2
ttgaaaCATGGGC
ttgaAACATGGgc
Created
Created
N
N
-0.283
-0.115

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