SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_012294
Gene Symbol: RAPGEF5
Description: Homo sapiens Rap guanine nucleotide exchange factor (GEF) 5 (RAPGEF5), mRNA.
Gene Location: chr7(-):22157907-22396533
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.22118386T>C COSN14733757 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-379-3p taaaacTTACATAagtaac
2
UAUGUAAC m7a Created 0.077000 0.004000 No effect
hsa-miR-380-3p taaaacTTACATAagtaac
2
UAUGUAAU m7a Created 0.082000 0.014000 No effect
hsa-miR-3924 taaaactTACATAagtaac
0 AUAUGUAU m6b Created no TS -0.051000 No effect
hsa-miR-410 taaaacTTATATaagtaac
9
AAUAUAAC m6b Disrupted -0.007000 no TS 0.050000
hsa-miR-411-3p taaaacTTACATAagtaac
2
UAUGUAAC m7a Created 0.077000 0.004000 No effect
hsa-miR-4495 taaaacTTACATaagtaac
1
AAUGUAAA m6b Created 0.138000 0.079000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22118532A>T COSN8516268 J30_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1208 ttgccattAACAGTGtttt
10
UCACUGUU m7b Disrupted -0.155000 0.040000 0.010000
hsa-miR-2053 ttgccATTAACAgtgtttt
13
GUGUUAAU m7b Disrupted 0.066000 0.093000 -0.010000
hsa-miR-569 ttgcCATTAACagtgtttt
13
AGUUAAUG m7b Disrupted -0.361000 -0.167000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22118700A>T COSN7974708 8047810 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662a-3p taatgTATCTTTaattagg
0 AAAGAUAG m7a Created NA NA -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22119441A>G COSN6875780 RK053_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p gtcatcTGTATAattgcca
13
CUAUACAA m6b Disrupted 0.058000 -0.011000 0.500000
hsa-let-7b-3p gtcatcTGTATAattgcca
13
CUAUACAA m6b Disrupted 0.058000 -0.011000 0.770000
hsa-let-7f-1-3p gtcatcTGTATAattgcca
13
CUAUACAA m6b Disrupted 0.055000 -0.018000 0.150000
hsa-let-7f-2-3p gtcatCTGTATAattgcca
16
CUAUACAG m7b Disrupted -0.269000 -0.272000 0.170000
hsa-miR-1185-1-3p gtcatCTGTATAattgcca
16
AUAUACAG m7b Disrupted -0.281000 -0.263000 No effect
hsa-miR-1185-2-3p gtcatCTGTATAattgcca
16
AUAUACAG m7b Disrupted -0.281000 -0.263000 No effect
hsa-miR-4275 gtcatctgtGTAATTGcca
0 CCAAUUAC m7b (m6b->m7b) no TS 0.046000 No effect
hsa-miR-466 gtcatcTGTGTAattgcca
0 AUACACAU m6b Created no TS 0.012000 -0.790000
hsa-miR-4672 gtcatCTGTGTAAttgcca
14
UUACACAG m8a Created -0.431000 -0.537000 -0.110000
hsa-miR-4789-5p gtcatcTGTATAattgcca
3
GUAUACAC m6b Disrupted -0.101000 -0.163000 No effect
hsa-miR-5683 gtCATCTGTAtaattgcca
0 UACAGAUG m8a (m8a->m7b) -0.073000 -0.034000 0.060000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22119499A>G COSN2216174 RK007_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-223-5p gttttacATACACatttgc
1
CGUGUAUU m6b Disrupted 0.003000 0.010000 0.090000
hsa-miR-297 gttttACATACAcatttgc
3
AUGUAUGU m7b Disrupted -0.040000 no TS No effect
hsa-miR-4666b gttttACATGCAcatttgc
2
UUGCAUGU m7b Created -0.299000 -0.391000 -0.210000
hsa-miR-5011-3p gttttaCATGCACatttgc
2
GUGCAUGG m7a Created -0.034000 -0.034000 No effect
hsa-miR-567 gttttACATACacatttgc
3
AGUAUGUU m6b Disrupted 0.010000 no TS 1.760000
hsa-miR-223-5p gttttacATACACatttgc
0 CGUGUAUU m6b Disrupted 0.003 0.01 0.09
hsa-miR-297 gttttACATACAcatttgc
0 AUGUAUGU m7b Disrupted -0.04 no TS No effect
hsa-miR-4666b gttttACATGCAcatttgc
0 UUGCAUGU m7b Created -0.299 -0.391 -0.21
hsa-miR-5011-3p gttttaCATGCACatttgc
0 GUGCAUGG m7a Created -0.034 -0.034 No effect
hsa-miR-567 gttttACATACacatttgc
0 AGUAUGUU m6b Disrupted 0.01 no TS 1.76

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22119718A>G COSN14532040 8068588 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4432 actctgcaAGTCTTacgta
2
AAAGACUC m6b Created -0.032000 0.050000 -0.080000
hsa-miR-499a-5p actctgcaAGTCTTAcgta
0 UUAAGACU m7b Created no TS 0.032000 -4.610000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22120109C>T COSN15122694 SM-4B296 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2392 cttttCCATCCTtgtcttc
0 UAGGAUGG m7b Disrupted -0.053000 0.006000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22120260C>G COSN8299205 PCSI_0279_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1183 cattttgTACAGTGacttc
0 CACUGUAG m7a Disrupted NA NA No effect
hsa-miR-1283 catTTTGTAGAgtgacttc
0 UCUACAAA m8a Created no TS 0.129000 -0.090000
hsa-miR-520d-5p catTTTGTAGagtgacttc
0 CUACAAAG m7a (m6b->m7a) NA NA No effect
hsa-miR-524-5p catTTTGTAGagtgacttc
0 CUACAAAG m7a (m6b->m7a) NA NA No effect
hsa-miR-668 cattttgtaGAGTGACttc
2
UGUCACUC m7b (m6b->m7b) -0.050000 -0.131000 -2.400000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22120278A>G COSN6875781 RK220_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-21-3p aaatgTGGTGTTtaaatgc
3
CAACACCA m7b Created -0.035000 -0.042000 -1.010000
hsa-miR-3591-3p aaatgTGGTGTTTaaatgc
3
AAACACCA m8a Created -0.025000 -0.023000 -1.070000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22122024G>A COSN7974709 8031867 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130b-5p aaacagGAAAGAGTtttta
3
ACUCUUUC m8a Created -0.021000 -0.160000 -0.230000
hsa-miR-3124-3p aaacAGGAAAGagttttta
10
ACUUUCCU m7b Created -0.058000 -0.239000 No effect
hsa-miR-3667-3p aaacAGGAAGGagttttta
2
ACCUUCCU m7b Disrupted -0.264000 0.045000 0.120000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.22122280C>A COSN2216175 RK083_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1257 agaCATTCACaggaaagcc
4
AGUGAAUG m7b (m7b->m6c) -0.362000 -0.043000 0.010000
hsa-miR-1914-5p agacattCACAGGaaagcc
0 CCCUGUGC m6b Disrupted -0.195000 -0.051000 No effect
hsa-miR-3074-5p agacattcaCAGGAAagcc
11
GUUCCUGC m6b Disrupted -0.067000 no TS No effect
hsa-miR-3121-5p agacattCAAAGGAaagcc
0 UCCUUUGC m7a Created no TS -0.101000 -0.070000
hsa-miR-1257 agaCATTCACaggaaagcc
0 AGUGAAUG m7b (m7b->m6c) -0.362 -0.043 0.01
hsa-miR-1914-5p agacattCACAGGaaagcc
0 CCCUGUGC m6b Disrupted -0.195 -0.051 No effect
hsa-miR-3074-5p agacattcaCAGGAAagcc
0 GUUCCUGC m6b Disrupted -0.067 no TS No effect
hsa-miR-3121-5p agacattCAAAGGAaagcc
0 UCCUUUGC m7a Created no TS -0.101 -0.07


Mutation Mutation ID Sample Name Cancer Type
chr7:g.22122297A>G COSN1347339 HCC108T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.22122395C>G COSN1347340 HCC2T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1827 ccccaCTGCCTCAcctccc
12
UGAGGCAG m8a Disrupted -0.564000 -0.282000 No effect
hsa-miR-2682-5p ccccACTGCCTcacctccc
2
CAGGCAGU m7b Disrupted -0.192000 -0.096000 No effect
hsa-miR-34a-5p cccCACTGCCtcacctccc
0 UGGCAGUG m7b (m7b->m6c) -0.254000 -0.127000 No effect
hsa-miR-34b-5p ccccACTGCCTcacctccc
2
UAGGCAGU m7b Disrupted -0.212000 -0.106000 No effect
hsa-miR-34c-5p cccCACTGCCTcacctccc
0 AGGCAGUG m8a Disrupted -0.236000 -0.118000 No effect
hsa-miR-4316 ccccactGCCTCACCtccc
4
GGUGAGGC m8a Disrupted 0.000000 no TS No effect
hsa-miR-449a cccCACTGCCtcacctccc
0 UGGCAGUG m7b (m7b->m6c) -0.180000 -0.090000 No effect
hsa-miR-449b-5p cccCACTGCCTcacctccc
0 AGGCAGUG m8a Disrupted -0.180000 -0.090000 No effect
hsa-miR-449c-5p ccccACTGCCTcacctccc
2
UAGGCAGU m7b Disrupted -0.212000 -0.106000 No effect
hsa-miR-4710 ccccactgCCTCACCtccc
5
GGGUGAGG m7b Disrupted 0.000000 -0.059000 No effect
hsa-miR-1827 ccccaCTGCCTCAcctccc
12
UGAGGCAG m8a Disrupted -0.564000 -0.282000 No effect
hsa-miR-2682-5p ccccACTGCCTcacctccc
2
CAGGCAGU m7b Disrupted -0.192000 -0.096000 No effect
hsa-miR-34a-5p cccCACTGCCtcacctccc
0 UGGCAGUG m7b (m7b->m6c) -0.254000 -0.127000 No effect
hsa-miR-34b-5p ccccACTGCCTcacctccc
2
UAGGCAGU m7b Disrupted -0.212000 -0.106000 No effect
hsa-miR-34c-5p cccCACTGCCTcacctccc
0 AGGCAGUG m8a Disrupted -0.236000 -0.118000 No effect
hsa-miR-4316 ccccactGCCTCACCtccc
4
GGUGAGGC m8a Disrupted 0.000000 no TS No effect
hsa-miR-449a cccCACTGCCtcacctccc
0 UGGCAGUG m7b (m7b->m6c) -0.180000 -0.090000 No effect
hsa-miR-449b-5p cccCACTGCCTcacctccc
0 AGGCAGUG m8a Disrupted -0.180000 -0.090000 No effect
hsa-miR-449c-5p ccccACTGCCTcacctccc
2
UAGGCAGU m7b Disrupted -0.212000 -0.106000 No effect
hsa-miR-4710 ccccactgCCTCACCtccc
5
GGGUGAGG m7b Disrupted 0.000000 -0.059000 No effect
hsa-miR-1827 ccccaCTGCCTCAcctccc
0 UGAGGCAG m8a Disrupted -0.564 -0.282 No effect
hsa-miR-2682-5p ccccACTGCCTcacctccc
0 CAGGCAGU m7b Disrupted -0.192 -0.096 No effect
hsa-miR-34a-5p cccCACTGCCtcacctccc
0 UGGCAGUG m7b (m7b->m6c) -0.254 -0.127 No effect
hsa-miR-34b-5p ccccACTGCCTcacctccc
0 UAGGCAGU m7b Disrupted -0.212 -0.106 No effect
hsa-miR-34c-5p cccCACTGCCTcacctccc
0 AGGCAGUG m8a Disrupted -0.236 -0.118 No effect
hsa-miR-4316 ccccactGCCTCACCtccc
0 GGUGAGGC m8a Disrupted 0 no TS No effect
hsa-miR-449a cccCACTGCCtcacctccc
0 UGGCAGUG m7b (m7b->m6c) -0.18 -0.09 No effect
hsa-miR-449b-5p cccCACTGCCTcacctccc
0 AGGCAGUG m8a Disrupted -0.18 -0.09 No effect
hsa-miR-449c-5p ccccACTGCCTcacctccc
0 UAGGCAGU m7b Disrupted -0.212 -0.106 No effect
hsa-miR-4710 ccccactgCCTCACCtccc
0 GGGUGAGG m7b Disrupted 0 -0.059 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
22118299 rs148106706 A A hsa-miR-5585-3p
4
CTATTCAtgcctc
Disrupted
N
-0.139
C hsa-miR-1827
hsa-miR-6808-5p
hsa-miR-6893-5p
hsa-miR-940
7
9
9
9
ctattcCTGCCTC
ctattCCTGCCTc
ctattCCTGCCTc
ctattCCTGCCTc
Created
Created
Created
Created
N
N
N
N
-0.27
-0.326
-0.326
-0.307
22120917 rs115634177 C C hsa-miR-3197
hsa-miR-6087
hsa-miR-6765-5p
2
2
2
catcaaCGCCTCA
catcaaCGCCTCA
catcaaCGCCTCA
Disrupted
Disrupted
Disrupted
N
N
N
-0.105
-0.08
-0.111
T hsa-miR-1256
hsa-miR-1827
1
2
catCAATGCCtca
catcaaTGCCTCA
Created
Created
N
N
-0.037
-0.006
22121212 rs111245004 - T hsa-miR-4432
hsa-miR-5197-3p
6
2
GAGTCTTctaaaa
gagTCTTCTAaaa
Unknown
Unknown
N
N
-0.118
0.006
- hsa-miR-1303
2
gagTCTCTAAAa
Unknown
N
-0.021
22122072 rs139171381 G
T hsa-miR-4495
hsa-miR-548u
hsa-miR-7161-5p
2
1
1
cgtcTTTACATgc
cGTCTTTAcatgc
cGTCTTTAcatgc
Created
Created
Created
N
N
N
0.02
-0.041
-0.038

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