SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_002886
Gene Symbol: RAP2B
Description: Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.
Gene Location: chr3(+):152880028-152886263
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr3:g.153163374G>A COSN1270039 HCC82T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3194-5p gggagcccGGCTGGCCtcc
3
GGCCAGCC m8a Disrupted -0.124000 no TS No effect
hsa-miR-3944-3p gggAGCCCGActggcctcc
0 UUCGGGCU m7b (m6b->m7b) no TS -0.190000 1.190000
hsa-miR-3194-5p gggagcccGGCTGGCCtcc
3
GGCCAGCC m8a Disrupted -0.124000 no TS No effect
hsa-miR-3944-3p gggAGCCCGActggcctcc
0 UUCGGGCU m7b (m6b->m7b) no TS -0.190000 1.190000
hsa-miR-3194-5p gggagcccGGCTGGCCtcc
0 GGCCAGCC m8a Disrupted -0.124 no TS No effect
hsa-miR-3944-3p gggAGCCCGActggcctcc
0 UUCGGGCU m7b (m6b->m7b) no TS -0.19 1.19

Mutation Mutation ID Sample Name Cancer Type
chr3:g.153165014G>T COSN7623796 PCSI_0002_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3162-3p ttgtaGGTAGGGAacaaga
0 UCCCUACC m8a Disrupted -0.320000 -0.136000 0.010000
hsa-miR-587 ttgtaggTATGGAAcaaga
0 UUUCCAUA m7b Created no TS 0.071000 -1.580000
hsa-miR-642b-5p ttgtaggtAGGGAACaaga
1
GGUUCCCU m7b Disrupted -0.174000 -0.080000 1.790000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.153165188A>T COSN1270040 HX14T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-331-5p gttATACCTAGtgatgttt
0 CUAGGUAU m8a Disrupted -0.027000 no TS 3.910000
hsa-miR-34c-3p gttataccTAGTGATgttt
2
AAUCACUA m7b Disrupted 0.046000 no TS 0.150000
hsa-miR-4457 gttataCCTTGTGAtgttt
1
UCACAAGG m8a Created 0.020000 -0.078000 -4.230000
hsa-miR-513b gttatacCTTGTGAtgttt
2
UUCACAAG m7b Created 0.059000 0.075000 -0.640000
hsa-miR-624-3p gttatACCTTGTGatgttt
0 CACAAGGU m8a Created no TS -0.037000 -2.150000
hsa-miR-331-5p gttATACCTAGtgatgttt
0 CUAGGUAU m8a Disrupted -0.027 no TS 3.91
hsa-miR-34c-3p gttataccTAGTGATgttt
0 AAUCACUA m7b Disrupted 0.046 no TS 0.15
hsa-miR-4457 gttataCCTTGTGAtgttt
0 UCACAAGG m8a Created 0.02 -0.078 -4.23
hsa-miR-513b gttatacCTTGTGAtgttt
0 UUCACAAG m7b Created 0.059 0.075 -0.64
hsa-miR-624-3p gttatACCTTGTGatgttt
0 CACAAGGU m8a Created no TS -0.037 -2.15

Mutation Mutation ID Sample Name Cancer Type
chr3:g.153165919C>T COSN6736843 RK220_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-105-5p aagaaaagGCATTTGgcat
11
UCAAAUGC m7b Disrupted 0.362000 0.296000 0.010000
hsa-miR-532-5p aagaaAAGGCATttggcat
6
CAUGCCUU m7b Disrupted -0.050000 no TS 0.060000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.153167276A>T COSN7623797 PCSI_0112_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-577 tcTTTATCTAttaactgga
3
UAGAUAAA m8a (m8a->m7a) 0.544000 0.494000 0.010000
hsa-miR-633 tctttatCTATTAactgga
2
CUAAUAGU m6b Disrupted 0.475000 0.398000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr3:g.153167528A>G COSN7623798 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.153167607A>C COSN8488506 3844_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1183 gtctaCTACAGTtagagaa
1
CACUGUAG m7b Disrupted -0.078000 0.017000 No effect
hsa-miR-20b-3p gtctACTACAGTtagagaa
1
ACUGUAGU m8a Disrupted -0.151000 no TS 1.540000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.153168405T>C COSN9136939 AOCS-148-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p ccattttCACTTTTaatgc
0 AAAAGUGC m7a Created 0.067000 0.067000 -0.020000
hsa-miR-3609 ccatttTCACTTTtaatgc
0 CAAAGUGA m7b Created -0.001000 -0.177000 -2.170000
hsa-miR-3646 ccattTTCATTTTtaatgc
3
AAAAUGAA m8a Disrupted 0.439000 0.535000 0.080000
hsa-miR-3662 ccatttTCATTTTtaatgc
3
GAAAAUGA m7b Disrupted 0.378000 0.468000 No effect
hsa-miR-548ah-5p ccatttTCACTTTTaatgc
0 AAAAGUGA m8a Created 0.002000 -0.174000 -0.010000
hsa-miR-548c-3p ccattttcATTTTTaatgc
3
CAAAAAUC m6b Disrupted 1.021000 0.949000 No effect
hsa-miR-548n ccattttcACTTTTaatgc
9
CAAAAGUA m6b Created 0.433000 0.405000 -0.350000
hsa-miR-548t-5p ccattttCACTTTTaatgc
9
CAAAAGUG m7b Created 0.477000 0.235000 -2.740000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
153163749 rs13093372 A A hsa-miR-205-5p
hsa-miR-218-2-3p
hsa-miR-5007-3p
hsa-miR-584-5p
hsa-miR-758-5p
10
3
6
3
3
aaccatATGAAGG
AACCATAtgaagg
aacCATATGAAgg
AACCATAtgaagg
AACCATAtgaagg
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.132
-0.097
-0.051
-0.064
-0.044
T hsa-miR-105-5p
hsa-miR-224-3p
hsa-miR-3671
hsa-miR-522-3p
hsa-miR-607
hsa-miR-7853-5p
6
3
6
3
6
6
aacCATTTGAagg
aACCATTTgaagg
aaccATTTGAAgg
aACCATTTgaagg
aaccATTTGAAgg
aacCATTTGAagg
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
0.017
-0.026
0.079
-0.026
0.107
0.014
153164233 rs140629909 G G hsa-miR-1183
hsa-miR-4742-3p
8
6
aaTACAGTAcaaa
AATACAGtacaaa
Disrupted
Disrupted
N
N
-0.026
-0.075
T hsa-miR-2054
9
aatacATTACAAa
Created
N
0.006
153166486 rs185548519 T T hsa-miR-577
6
tcTTTATCTtggg
Disrupted
N
0.206
C hsa-miR-548ag
hsa-miR-548ai
hsa-miR-548ba
hsa-miR-570-5p
hsa-miR-6814-5p
5
5
5
5
2
tctTTACCTTggg
tctTTACCTTggg
tctTTACCTTggg
tctTTACCTTggg
tctttaCCTTGGG
Created
Created
Created
Created
Created
N
N
N
N
N
0.092
0.092
0.101
0.092
-0.055
153167421 rs139001345 G G hsa-miR-3162-3p
hsa-miR-4740-3p
6
2
tctcgGGTAGGGt
TCTCGGGtagggt
Disrupted
Disrupted
N
N
-0.136
-0.097
A hsa-miR-454-5p
6
tctcgGATAGGGt
Created
N
-0.054
153167810 rs6785014 T A hsa-miR-1251-3p
hsa-miR-3152-5p
hsa-miR-4774-3p
hsa-miR-6836-3p
0 gagGCAAAGCcta
GAGGCAAAgccta
gAGGCAAAgccta
GAGGCAAagccta
Created
Created
Created
Created
N
N
N
N
-0.091
-0.359
-0.087
-0.125
T hsa-miR-31-3p
hsa-miR-4633-5p
hsa-miR-532-5p
0 gagGCATAGCcta
gAGGCATAgccta
gAGGCATAgccta
Disrupted
Disrupted
Disrupted
N
N
N
-0.184
-0.109
-0.096
153168070 rs3821547 A A hsa-miR-1252-3p
hsa-miR-1253
hsa-miR-3646
hsa-miR-6770-5p
2
2
2
2
cttCTCATTTAgt
CTTCTCAtttagt
cttcTCATTTAgt
CTTCTCAtttagt
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
-0.154
-0.088
0.039
-0.143

Genome Browser