SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_173848
Gene Symbol:	RALYL
Description:	Homo sapiens RALY RNA binding protein-like (RALYL), transcript variant 1, mRNA.
Gene Location:	chr8(+):85095585-85834078
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.84921428A>G			COSN5690335		RK143_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-410	aaaaGTTATATTtctgccc	0	AAUAUAAC	m8a	Disrupted	-0.058000	-0.002000	0.030000
hsa-miR-4803	aaaagTTATGTTtctgccc	8	UAACAUAA	m7b	Created	-0.133000	-0.136000	No effect
hsa-miR-494	aaaagttATGTTTCtgccc	6	UGAAACAU	m7b	Created	-0.121000	-0.195000	-0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.84921582G>A			COSN14731215		CHC322T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1295b-5p	tcagTCTGGGTatgagatt	4	CACCCAGA	m7b	Disrupted	-0.369000	no TS	6.960000
hsa-miR-1912	tcagTCTGGGTAtgagatt	4	UACCCAGA	m8a	Disrupted	-0.380000	no TS	3.200000
hsa-miR-4482-5p	tcagtCTGGGTatgagatt	4	AACCCAGU	m6b	Disrupted	-0.169000	no TS	3.860000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.84921617C>T			9_91933		CRC-8-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-182-5p	actagaTTGCCAAggaaaa	0	UUUGGCAA	m7b	Disrupted	-0.151	no TS	No effect
hsa-miR-212-5p	actagattGCCAAGGaaaa	0	ACCUUGGC	m7b	Disrupted	-0.464	no TS	1.61

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.84921669C>T			COSN6366954		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3171	tagtgcATACATCatgtca	5	AGAUGUAU	m7b	Disrupted	-0.241000	no TS	1.700000
hsa-miR-675-3p	tagtGCATACAtcatgtca	5	CUGUAUGC	m7b	Disrupted	-0.210000	no TS	1.720000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.84921698G>T			COSN9271066		C0028T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-384	tgttcCTAGGAActctcca	6	AUUCCUAG	m7b	Disrupted	-0.085000	no TS	2.300000
hsa-miR-5571-3p	tgttCCTAGGAactctcca	3	GUCCUAGG	m7b	Disrupted	-0.376000	no TS	3.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.84921794G>C			COSN14989792		SM-4AX85		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-155-3p	cagaccGTAGGAGaattca	0	CUCCUACA	m7a	Disrupted	NA	NA	0.320000
hsa-miR-4279	cagaccgtAGGAGAattca	14	CUCUCCUC	m6b	Disrupted	-0.124000	no TS	0.200000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
84921152	rs147331612	-	-	hsa-miR-4803	8	taaTTATGTTttt	Unknown	N	-0.133
			T
84921582	rs12604	G	G	hsa-miR-1295b-5p hsa-miR-1912 hsa-miR-3130-5p hsa-miR-4482-5p	4 4 4 4	gTCTGGGTAtgag gTCTGGGTAtgag gtCTGGGTAtgag gtCTGGGTAtgag	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.369 -0.38 -0.169 -0.169
			A	hsa-miR-5586-5p	4	gtCTGGATAtgag	Created	N	-0.126
84921672	rs28605830	C	C	hsa-miR-3171	5	ATACATCAtgtca	Disrupted	N	-0.241

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