SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002843
Gene Symbol:	PTPRJ
Description:	Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), transcript variant 2, mRNA.
Gene Location:	chr11(+):48002109-48192394
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.48168173C>T			COSN1535935		RK083_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4785	tgagaatggCGACTCaaat	2	AGAGUCGG	m6b	Disrupted	-0.277000	-0.117000	0.010000
hsa-miR-5702	tgagaatggTGACTCAaat	2	UGAGUCAG	m7a	(m6b->m7a)	0.128000	0.062000	No effect
hsa-miR-4785	tgagaatggCGACTCaaat	0	AGAGUCGG	m6b	Disrupted	-0.277	-0.117	0.01
hsa-miR-5702	tgagaatggTGACTCAaat	0	UGAGUCAG	m7a	(m6b->m7a)	0.128	0.062	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.48169424A>G			COSN1535936		RK177_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4474-3p	ggaAGCCACAttgtcctca	1	UUGUGGCU	m7b	(m7b->m6b)	-0.038000	no TS	0.180000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.48169788C>T			COSN8681953		AOCS-126-1-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3202	tcttCCCTTCCgcctggtg	4	UGGAAGGG	m7b	Disrupted	-0.077000	no TS	No effect
hsa-miR-3937	tcttcccttCCGCCTGgtg	5	ACAGGCGG	m7b	(m7b->m6c)	-0.154000	no TS	0.300000
hsa-miR-5681a	tcttCCCTTTCgcctggtg	8	AGAAAGGG	m7b	Created	-0.033000	-0.026000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.48169795G>T			COSN5306424		RK043_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1911-3p	ttccGCCTGGTGtgggctt	4	CACCAGGC	m8a	Disrupted	-0.327000	-0.288000	No effect
hsa-miR-3937	ttCCGCCTGTtgtgggctt	5	ACAGGCGG	m8a	(m7a->m8a)	-0.154000	-0.182000	0.210000
hsa-miR-4733-3p	ttccgCCTGGTGtgggctt	3	CCACCAGG	m7b	Disrupted	0.015000	no TS	No effect
hsa-miR-5003-5p	ttccgccTGTTGTGggctt	0	UCACAACA	m7b	Created	no TS	0.097000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.48169926G>A			COSN10088019		C0076T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2355-5p	aaagggCTGGGGAcagggc	7	AUCCCCAG	m7b	Disrupted	-0.017000	no TS	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
48168052	rs1058417	A	A	hsa-miR-4508 hsa-miR-4785 hsa-miR-5090 hsa-miR-6727-5p hsa-miR-6775-5p	1 0 1 1 1	GCCCCGActccgc gccCCGACTCcgc GCCCCGActccgc GCCCCGActccgc GCCCCGActccgc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.187 -0.117 -0.201 -0.267 -0.203
			G	hsa-miR-6784-5p	1	GCCCCGGctccgc	Created	N	-0.251
48168054	rs7951730	C	T	hsa-miR-4785 hsa-miR-7846-3p	0	cCCGACTCcgctt cccgaCTCCGCTt	Created Created	N N	-0.117 -0.177
			C	hsa-miR-4781-5p hsa-miR-7704	0	cccgaCCCCGCTt ccCGACCCCgctt	Disrupted Disrupted	N N	-0.208 -0.09

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