SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000021
Gene Symbol:	PSEN1
Description:	Homo sapiens presenilin 1 (PSEN1), transcript variant 1, mRNA.
Gene Location:	chr14(+):73603142-73690399
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.73219744C>T			COSN8849584		AOCS-120-3-6		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4275	ctgtatTAATTGaattctg	3	CCAAUUAC	m6b	Created	-0.105000	-0.120000	No effect
hsa-miR-935	ctgtatTAACTGaattctg	2	CCAGUUAC	m6b	Disrupted	-0.060000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.73221439G>C			COSN9617780		C0026T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3123	ttcTTCTCTGaagagggta	0	CAGAGAAU	m7a	(m7a->m6a)	-0.143000	-0.143000	No effect
hsa-miR-3919	ttcTTCTCTGaagagggta	0	GCAGAGAA	m7b	(m7b->m6b)	0.113000	no TS	No effect
hsa-miR-4756-3p	ttctTCTCTGaagagggta	0	CCAGAGAU	m6b	Disrupted	0.049000	no TS	No effect
hsa-miR-526b-5p	ttcttctCTCAAGAGggta	0	CUCUUGAG	m8a	Created	no TS	0.048000	-1.590000
hsa-miR-877-3p	ttcttctctGAAGAGGgta	2	UCCUCUUC	m7b	(m7b->m6c)	0.032000	-0.017000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.73222207T>C			COSN9617781		C0016T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3978	gaagCTTTCCAagcaactt	0	GUGGAAAG	m7b	Created	no TS	0.131000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
73219741	rs200629432	T	T	hsa-miR-374c-5p hsa-miR-655-3p hsa-miR-935	3 3 2	cTGTATTAActga cTGTATTAActga ctgtatTAACTGA	Disrupted Disrupted Disrupted	N N N	-0.08 -0.091 -0.06
			G	hsa-miR-4277 hsa-miR-485-3p hsa-miR-539-3p hsa-miR-584-3p	2 3 3 2	ctgtatGAACTGA cTGTATGAActga cTGTATGAActga ctgtatGAACTGA	Created Created Created Created	N N N N	-0.101 -0.149 -0.202 -0.098
73220380	rs202134342	A	A	hsa-miR-4778-3p	12	taAAGAAGAgtaa	Disrupted	N	0.055
			G	hsa-miR-6881-3p hsa-miR-877-3p	12 12	taAAGAGGAgtaa taAAGAGGAgtaa	Created Created	N N	-0.069 -0.01
73223402	rs190718487	G	G	hsa-miR-4275	5	aaatacGTAATTG	Disrupted	N	-0.105
			A	hsa-miR-3924	2	aaATACATAAttg	Created	N	-0.168

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