SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_206909
Gene Symbol: PSD3
Description: Homo sapiens pleckstrin and Sec7 domain containing 3 (PSD3), transcript variant 1, mRNA.
Gene Location: chr8(-):18384812-18666405
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr8:g.18528741A>G 9_91438 CRC-8-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-664-3p ggtcgccATGAATAagtct
 4
 UAUUCAUU m7a Created 0.005 0.168 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18529293G>T 0_307 Lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-328 caAGGGCCAGggtggaatc
 8
 CUGGCCCU m8a (m8a->m7b) -0.022 -0.049 -0.32
hsa-miR-3620 caagggcCAGGGTGgaatc
 7
 UCACCCUG m7b Disrupted -0.16 -0.173 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18529606C>G COSN9607725 AOCS-079-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4326 ctgtAGGAACAagagtaat
 7
 UGUUCCUC m7a Disrupted -0.109000 -0.123000 No effect
hsa-miR-4778-3p ctgtagGAAGAAGAgtaat
 15
 UCUUCUUC m8a Created 0.157000 0.237000 -0.130000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18529621G>A ICGC_7E8B6C58-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3163 gatacTTTTATAaaactgt
 0 UAUAAAAU m7a Created 0.455 0.648 -0.02
hsa-miR-340-5p gatactTTTATAAaactgt
 0 UUAUAAAG m7a Created 0.308 0.493 No effect
hsa-miR-520d-5p gatactTTTGTAaaactgt
 0 CUACAAAG m6b Disrupted 0.622 0.479 No effect
hsa-miR-524-5p gatactTTTGTAaaactgt
 0 CUACAAAG m6b Disrupted 0.579 0.439 No effect
hsa-miR-548n gaTACTTTTGtaaaactgt
 0 CAAAAGUA m8a (m8a->m7b) 0.403 0.474 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18529690G>T COSN9607726 AOCS-056-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p tttgataTGTATAataata
 3
 CUAUACAA m6b Created 0.075000 0.159000 -0.180000
hsa-let-7b-3p tttgataTGTATAataata
 3
 CUAUACAA m6b Created 0.098000 0.182000 -0.010000
hsa-let-7f-1-3p tttgataTGTATAataata
 3
 CUAUACAA m6b Created 0.057000 0.141000 -0.150000
hsa-let-7f-2-3p tttgataTGTATAataata
 3
 CUAUACAG m6b Created 0.271000 0.347000 -0.020000
hsa-miR-1185-1-3p tttgataTGTATAataata
 3
 AUAUACAG m6b Created 0.271000 0.350000 No effect
hsa-miR-1185-2-3p tttgataTGTATAataata
 3
 AUAUACAG m6b Created 0.271000 0.354000 -0.010000
hsa-miR-4789-5p tttgataTGTATAataata
 0 GUAUACAC m6b Created 0.321000 0.391000 -0.010000
hsa-miR-5580-3p tttgATATGTataataata
 0 CACAUAUG m6b Created -0.052000 0.030000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18530431C>A COSN15026011 LP6007422-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3140-3p gaaatatCAAAAGCactaa
 10
 AGCUUUUG m7b Created 0.075000 0.124000 -0.070000
hsa-miR-3689a-5p gaaATATCACAagcactaa
 4
 UGUGAUAU m8a Disrupted 0.124000 0.099000 0.120000
hsa-miR-3689b-5p gaaATATCACAagcactaa
 4
 UGUGAUAU m8a Disrupted 0.124000 0.099000 0.120000
hsa-miR-3689e gaaATATCACAagcactaa
 4
 UGUGAUAU m8a Disrupted 0.124000 0.099000 0.120000
hsa-miR-3689f gaaATATCACAagcactaa
 4
 UGUGAUAU m8a Disrupted 0.103000 0.099000 0.230000
hsa-miR-636 gaaatatcaCAAGCACtaa
 3
 UGUGCUUG m7b (m7b->m6b) -0.086000 -0.042000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18532684G>A 13_177 SJMB028_D Medulloblastoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1587 cgcCAGCCCAtaggcattt
 6
 UUGGGCUG m7b (m6c->m7b) -0.008 -0.024 No effect
hsa-miR-4498 cgCCAGCCCAtaggcattt
 6
 UGGGCUGG m8a (m7b->m8a) -0.12 -0.191 -0.09
hsa-miR-4656 cgcCAGCCCAtaggcattt
 6
 UGGGCUGA m7a (m6b->m7a) -0.029 -0.065 No effect
hsa-miR-4741 cgcCAGCCCGtaggcattt
 6
 CGGGCUGU m7a (m7a->m6b) -0.021 -0.059 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18533207G>A COSN2268707 RK055_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4757-5p atgaagGAGGCCaagagtt
 0 AGGCCUCU m6b Disrupted -0.106000 -0.054000 No effect
hsa-miR-4757-5p atgaagGAGGCCaagagtt
 0 AGGCCUCU m6b Disrupted -0.106 -0.054 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18533558A>G COSN5678184 RK060_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3074-3p tacttattTGATATacatt
 8
 GAUAUCAG m6b Created -0.200000 -0.140000 No effect
hsa-miR-3671 tactTATTTGATatacatt
 9
 AUCAAAUA m8a Created 0.138000 0.205000 -0.040000
hsa-miR-5692a tacTTATTTGatatacatt
 9
 CAAAUAAU m7a (m6b->m7a) 0.859000 0.682000 No effect
hsa-miR-656 tacttattTAATATacatt
 10
 AAUAUUAU m6b Disrupted 0.470000 0.322000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr8:g.18533641G>C COSN8575975 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.18533667T>A COSN8575976 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3674 catgtcaTCTACAAgcttc
 0 AUUGUAGA m7b Disrupted 0.092000 no TS 0.060000
hsa-miR-3935 catgtcATCTACAagcttc
 1
 UGUAGAUA m7a Disrupted 0.007000 -0.042000 0.090000
hsa-miR-653 catgtcaTCAACAagcttc
 0 GUGUUGAA m6b Created no TS 0.079000 -0.390000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18533707T>C COSN6918566 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-30a-5p aaaTGTTTACActaagccg
 19
 UGUAAACA m8a Created -0.083000 0.044000 No effect
hsa-miR-30b-5p aaaTGTTTACActaagccg
 19
 UGUAAACA m8a Created -0.090000 0.027000 -0.010000
hsa-miR-30c-5p aaaTGTTTACActaagccg
 19
 UGUAAACA m8a Created -0.090000 0.027000 -0.010000
hsa-miR-30d-5p aaaTGTTTACActaagccg
 19
 UGUAAACA m8a Created -0.083000 0.044000 -0.010000
hsa-miR-30e-5p aaaTGTTTACActaagccg
 19
 UGUAAACA m8a Created -0.093000 0.034000 No effect
hsa-miR-3591-5p aaatgtttACACTAAgccg
 3
 UUUAGUGU m7b Created 0.061000 0.136000 -0.640000
hsa-miR-4280 aaatgttTACACTaagccg
 0 GAGUGUAG m6b Created -0.047000 -0.016000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr8:g.18534807C>T ICGC_A3C2E9F6-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr8:g.18534817C>T ICGC_C45E2E14-2A78-11E2-BDED-1EFD496BB9B8 CPCG_0103_Pr_P_P4 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.18535230A>T COSN6518271 HX36T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-28-3p gtgctgggaATCTAGTtgc
 5
 CACUAGAU m7b (m7b->m6b) -0.002000 0.087000 0.550000
hsa-miR-376a-5p gtgctggGAATCTAgttgc
 2
 GUAGAUUC m7b Disrupted 0.022000 0.030000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18535297T>A COSN2268708 RK021_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-31-5p tatgtgaaaTCTTGCCcag
 7
 AGGCAAGA m7b (m7b->m6b) -0.211000 no TS No effect
hsa-miR-31-5p tatgtgaaaTCTTGCCcag
 0 AGGCAAGA m7b (m7b->m6b) -0.211 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18535434G>C COSN14538053 8068588 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3133 tgctcaGTTCTTTtatgta
 13
 UAAAGAAC m7b Created 0.398000 0.318000 No effect
hsa-miR-4511 tgctcAGTTCTTttatgta
 0 GAAGAACU m7b Created no TS -0.109000 -2.160000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.18535526A>T COSN8575977 tumor_4174905 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-18a-5p agctaatGCACCTTttctg
 18
 UAAGGUGC m7b Disrupted -0.270000 no TS 0.550000
hsa-miR-18b-5p agctaatGCACCTTttctg
 18
 UAAGGUGC m7b Disrupted -0.270000 no TS 1.050000
hsa-miR-4735-3p agctaatGCACCTTTtctg
 18
 AAAGGUGC m8a Disrupted -0.288000 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
18527711 rs3087875 T A hsa-miR-4326
hsa-miR-607
0 tttgaaAGGAACA
TTTGAAAggaaca
 Created
Created
N
N
 -0.109
0.071
18528136 rs111805350 C C hsa-miR-3177-5p
hsa-miR-4280
2
2
 TGTACACtagcgg
tgTACACTAgcgg
 Disrupted
Disrupted
N
N
 -0.127
-0.047
G hsa-miR-1183
2
 tgTACAGTAgcgg
 Created
N
 -0.023
18533181 rs901933 A A hsa-miR-1238-3p
hsa-miR-452-5p
hsa-miR-4676-3p
hsa-miR-670-3p
hsa-miR-892c-3p
hsa-miR-943
5
2
2
5
2
1
 GAGGAAAcagtca
gaggAAACAGTca
gaggAAACAGTca
GAGGAAAcagtca
gaggAAACAGTca
gaggaaACAGTCA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.056
0.168
0.15
0.057
0.15
-0.022
C hsa-miR-218-1-3p
hsa-miR-4326
3
5
 gaGGAACCAgtca
GAGGAACcagtca
 Created
Created
N
N
 -0.047
0.051
18533520 rs138064482 C C hsa-miR-513b-3p
5
 ttcTGACATTtag
 Disrupted
N
 0.059
T hsa-miR-2115-3p
hsa-miR-3074-3p
hsa-miR-361-5p
6
7
6
 TTCTGATAtttag
ttCTGATATttag
tTCTGATAtttag
 Created
Created
Created
N
N
N
 0.045
-0.032
-0.024
18533561 rs181724678 T T hsa-miR-5692a
2
 tacTTATTTAata
 Disrupted
N
 0.177
C hsa-miR-4477a
10
 tacttaCTTAATA
 Created
N
 0.087
18533664 rs901934 G A hsa-miR-100-3p
hsa-miR-3674
hsa-miR-376a-2-5p
hsa-miR-3935
0 atctaCAAGCTTc
aTCTACAAgcttc
ATCTACAagcttc
ATCTACAagcttc
 Created
Created
Created
Created
N
N
N
N
 0.005
0.092
0.036
0.049
G hsa-miR-3928-5p
hsa-miR-6806-3p
hsa-miR-99a-3p
hsa-miR-99b-3p
1
1
0
0
 atctacGAGCTTC
atctacGAGCTTC
atctaCGAGCTTc
atctaCGAGCTTc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.023
-0.045
-0.088
-0.069
18533665 rs114627485 C C hsa-miR-100-3p
hsa-miR-3674
hsa-miR-376a-2-5p
hsa-miR-3935
0 catctaCAAGCTT
caTCTACAAgctt
cATCTACAagctt
cATCTACAagctt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 0.005
0.092
0.036
0.049
T hsa-miR-21-5p
hsa-miR-590-5p
0 catctATAAGCTt
catctATAAGCTt
 Created
Created
N
N
 0.011
0.048
18533818 rs186435182 G
C hsa-miR-3689a-5p
hsa-miR-3689b-5p
hsa-miR-3689e
hsa-miR-3689f
hsa-miR-8066
2
2
2
2
1
 gTATCACAttgat
gTATCACAttgat
gTATCACAttgat
gTATCACAttgat
gtaTCACATTgat
 Created
Created
Created
Created
Created
N
N
N
N
N
 0.026
0.026
0.026
0.036
0.021
18534326 rs61467067 G G hsa-miR-4719
2
 cTTTGTGAtttcc
 Disrupted
N
 0.108
A hsa-miR-520d-5p
hsa-miR-524-5p
2
2
 CTTTGTAAtttcc
CTTTGTAAtttcc
 Created
Created
N
N
 0.199
0.199
18535224 rs192070111 T T hsa-miR-28-3p
hsa-miR-708-3p
1
1
 ATCTAGTtgctcc
aTCTAGTTgctcc
 Disrupted
Disrupted
N
N
 -0.089
-0.078
C hsa-miR-6081
hsa-miR-646
1
1
 atctagCTGCTCC
atctAGCTGCTcc
 Created
Created
N
N
 -0.197
-0.136
18535608 rs192606715 T T hsa-let-7a-3p
hsa-let-7b-3p
hsa-let-7f-1-3p
hsa-miR-300
hsa-miR-381-3p
hsa-miR-4666a-3p
hsa-miR-98-3p
7
7
7
7
7
7
7
 aTTGTATAttttt
aTTGTATAttttt
aTTGTATAttttt
aTTGTATAttttt
aTTGTATAttttt
ATTGTATAttttt
aTTGTATAttttt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.143
-0.143
-0.143
-0.063
-0.06
-0.219
-0.161
C hsa-let-7c-3p
7
 aTTGTACAttttt
 Created
N
 -0.205

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