SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_002737
Gene Symbol:	PRKCA
Description:	Homo sapiens protein kinase C, alpha (PRKCA), mRNA.
Gene Location:	chr17(+):64298925-64806862
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66804725A>C			COSN4770182		tumor_4121361		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-451b	actgTCTTGCTActtttca	3	UAGCAAGA	m8a	Created	0.253000	0.097000	-1.380000
hsa-miR-4696	actGTCTTGCtacttttca	3	UGCAAGAC	m7b	(m6b->m7b)	0.041000	-0.120000	-0.820000
hsa-miR-548l	actgtcttgATACTTTTca	2	AAAAGUAU	m8a	(m8a->m7b)	-0.018000	-0.038000	No effect
hsa-miR-562	actgtcttGCTACTTTtca	0	AAAGUAGC	m8a	Created	no TS	-0.143000	-0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66806362T>G			COSN9320521		AOCS-112-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-218-2-3p	aaGAACCATGtcttctgcc	1	CAUGGUUC	m8a	(m7a->m8a)	-0.007000	0.021000	0.010000
hsa-miR-224-3p	aagaACCATTTcttctgcc	2	AAAAUGGU	m7b	Disrupted	0.280000	0.172000	0.020000
hsa-miR-3617	aagaaccATGTCTTctgcc	0	AAAGACAU	m7b	Created	no TS	0.165000	No effect
hsa-miR-522-3p	aagaACCATTTcttctgcc	2	AAAAUGGU	m7b	Disrupted	0.283000	0.212000	0.010000
hsa-miR-5680	aagaacCATTTCTtctgcc	2	GAGAAAUG	m7b	Disrupted	0.317000	0.149000	0.010000
hsa-miR-641	aagaaccATGTCTTctgcc	0	AAAGACAU	m7b	Created	no TS	0.174000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66806408G>T			COSN5419493		RK118_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3914	ctccaggGGTTCCTggctc	1	AAGGAACC	m7b	Created	0.073000	0.186000	No effect
hsa-miR-4640-3p	ctccAGGGGGTcctggctc	0	CACCCCCU	m7b	Disrupted	0.018000	no TS	No effect
hsa-miR-873-5p	ctccagggGTTCCTGgctc	1	GCAGGAAC	m7b	Created	0.041000	0.129000	-1.090000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66807607A>G			COSN15571042		C0021T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2115-3p	ccctTTCTGATGccacgta	12	CAUCAGAA	m8a	Disrupted	0.022000	-0.123000	0.140000
hsa-miR-4642	ccctttctGATGCCAcgta	0	AUGGCAUC	m7b	Disrupted	-0.001000	no TS	0.010000
hsa-miR-4711-5p	ccctttCTGATGCcacgta	4	UGCAUCAG	m7b	Disrupted	-0.030000	0.006000	0.010000
hsa-miR-593-5p	ccctttcTGGTGCCacgta	1	AGGCACCA	m7b	Created	-0.157000	-0.271000	-0.190000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66807711A>C			COSN1726339		RK023_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-579	gcccaaCAAATGAttgttg	1	UUCAUUUG	m7b	Disrupted	0.276000	0.128000	No effect
hsa-miR-644b-3p	gcccaaCAAATGAttgttg	1	UUCAUUUG	m7b	Disrupted	0.277000	0.138000	No effect
hsa-miR-579	gcccaaCAAATGAttgttg	1	UUCAUUUG	m7b	Disrupted	0.276	0.128	No effect
hsa-miR-644b-3p	gcccaaCAAATGAttgttg	1	UUCAUUUG	m7b	Disrupted	0.277	0.138	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66807771G>A			PRKCA_E17_UTR_3		SJHYPO046_D		Hypodiploid_ALL
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-130b-5p	ttcctgGAAAGAGgatgca	0	ACUCUUUC	m7b	Created	0.224	0.371	-1.53
hsa-miR-3124-3p	ttcctGGAAAGaggatgca	0	ACUUUCCU	m6b	Created	0.121	0.246	-0.01
hsa-miR-3667-3p	ttcctGGAAGGaggatgca	1	ACCUUCCU	m6b	Disrupted	0.428	0.353	0.33
hsa-miR-660-3p	ttcctggaAGGAGGatgca	0	ACCUCCUG	m6b	Disrupted	0.074	0.018	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808084C>T			COSN7443128		8066500		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-149-3p	tttcCCCTCCCcaccttga	1	AGGGAGGG	m7b	Disrupted	-0.245000	-0.203000	0.010000
hsa-miR-3150a-3p	tttcccCTCCCCAccttga	1	CUGGGGAG	m7b	Disrupted	-0.060000	-0.119000	0.010000
hsa-miR-3175	tttcccCTCCCCaccttga	1	CGGGGAGA	m6b	Disrupted	-0.203000	-0.214000	No effect
hsa-miR-4728-5p	tttcCCCTCCCcaccttga	1	UGGGAGGG	m7b	Disrupted	-0.216000	-0.211000	2.190000
hsa-miR-491-5p	tttccccTCCCCACcttga	1	AGUGGGGA	m7b	Disrupted	-0.041000	-0.106000	-0.030000
hsa-miR-5192	tttcccCTCTCCaccttga	0	AGGAGAGU	m6b	Created	no TS	0.042000	-0.590000
hsa-miR-92a-2-5p	tttcccctCCCCACCttga	1	GGGUGGGG	m7b	Disrupted	-0.167000	-0.151000	0.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808316G>T			COSN1200066		HX5T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3148	tttgtttTTTTTCCtgttt	5	UGGAAAAA	m7b	Created	0.197000	0.270000	No effect
hsa-miR-873-5p	tttgtttttGTTCCTGttt	1	GCAGGAAC	m7b	(m7b->m6c)	0.041000	0.102000	-0.790000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808322G>T			COSN8603662		J38_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-873-5p	tttGTTCCTGttttttttt	1	GCAGGAAC	m7b	(m7b->m6b)	0.041000	0.102000	0.590000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808337G>T			COSN8603663		J83_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3180-5p	tttttttttTCTGGAAttt	2	CUUCCAGA	m7b	(m6c->m7b)	0.123000	0.071000	No effect
hsa-miR-338-3p	ttttttttTGCTGGAattt	0	UCCAGCAU	m7a	Disrupted	-0.052000	no TS	No effect
hsa-miR-3613-3p	tttTTTTTTGctggaattt	0	ACAAAAAA	m7b	(m7b->m6b)	0.771000	0.622000	-0.510000
hsa-miR-4530	ttttttttTGCTGGaattt	0	CCCAGCAG	m6b	Disrupted	0.033000	0.073000	0.010000
hsa-miR-520a-5p	tttttttttTCTGGAattt	1	CUCCAGAG	m6b	Created	0.122000	0.103000	-0.220000
hsa-miR-525-5p	tttttttttTCTGGAattt	1	CUCCAGAG	m6b	Created	0.091000	0.079000	No effect
hsa-miR-545-3p	ttttttTTTGCTGgaattt	0	UCAGCAAA	m7b	Disrupted	0.123000	0.117000	No effect
hsa-miR-548p	tttttTTTTGCTggaattt	6	UAGCAAAA	m7b	Disrupted	0.018000	-0.038000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808697C>T			COSN14500186		8069334		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5003-5p	ggagTGTTGTGAaattttt	0	UCACAACA	m8a	Created	no TS	-0.015000	-8.890000
hsa-miR-513b	ggagtgTTGTGAAattttt	0	UUCACAAG	m7a	Created	no TS	0.025000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808916G>T			COSN6109852		RK216_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-221-5p	caccatgttTGCCAGGatg	1	ACCUGGCA	m7b	(m6c->m7b)	0.046000	-0.025000	-0.010000
hsa-miR-3128	caccatgtTTGCCAGgatg	0	UCUGGCAA	m7b	Created	0.060000	0.042000	-0.010000
hsa-miR-3190-5p	caccatgtTGGCCAGgatg	1	UCUGGCCA	m7b	Disrupted	-0.050000	-0.017000	0.360000
hsa-miR-4470	caccatGTTTGCCAggatg	4	UGGCAAAC	m8a	Created	0.106000	0.120000	-0.310000
hsa-miR-4720-5p	caccatgttTGCCAGGatg	0	CCUGGCAU	m7a	(m6b->m7a)	-0.042000	-0.042000	-0.380000
hsa-miR-548s	caccatgTTGGCCAggatg	1	AUGGCCAA	m7b	Disrupted	0.063000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66808917G>T			COSN6109853		RK216_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-221-5p	accatgttgGCCAGGatgg	1	ACCUGGCA	m6b	Disrupted	0.046000	0.086000	No effect
hsa-miR-3190-5p	accatgtTGGCCAGgatgg	1	UCUGGCCA	m7b	Disrupted	-0.050000	-0.017000	0.360000
hsa-miR-3690	accatgttGTCCAGGatgg	1	ACCUGGAC	m7b	Created	-0.012000	-0.103000	No effect
hsa-miR-4254	accatgttgTCCAGGatgg	1	GCCUGGAG	m6b	Created	0.075000	0.084000	-0.290000
hsa-miR-4638-3p	accatgtTGTCCAGGatgg	6	CCUGGACA	m8a	Created	-0.206000	-0.200000	No effect
hsa-miR-548s	accatgTTGGCCAggatgg	1	AUGGCCAA	m7b	Disrupted	0.063000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66809688C>T			COSN5221249		SS6003113		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3157-5p	gaactTGGCTGActgatgc	0	UUCAGCCA	m7b	Created	no TS	-0.081000	-1.100000
hsa-miR-4480	gaACTTGGCTgactgatgc	0	AGCCAAGU	m8a	(m7a->m8a)	-0.016000	-0.043000	No effect
hsa-miR-4691-3p	gaactTGGCTGactgatgc	0	CCAGCCAC	m6b	Created	no TS	-0.031000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66810177C>T			COSN9672644		C0038T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66810421G>A			COSN9223202		8057643		[pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-548aj-5p	attgCTTTTGCtacatgat	7	UGCAAAAG	m7b	Disrupted	-0.016000	0.087000	0.660000
hsa-miR-548g-5p	attgCTTTTGCtacatgat	7	UGCAAAAG	m7b	Disrupted	-0.016000	0.087000	0.660000
hsa-miR-548p	attgcTTTTGCTAcatgat	6	UAGCAAAA	m8a	Disrupted	0.018000	0.121000	0.260000
hsa-miR-548x-5p	attgCTTTTGCtacatgat	7	UGCAAAAG	m7b	Disrupted	-0.016000	0.087000	0.660000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66810538A>G			COSN6659872		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7a-3p	tccttcTGTATAagcacct	0	CUAUACAA	m6b	Disrupted	-0.180000	-0.185000	0.020000
hsa-let-7b-3p	tccttcTGTATAagcacct	0	CUAUACAA	m6b	Disrupted	-0.187000	-0.185000	0.420000
hsa-let-7f-1-3p	tccttcTGTATAagcacct	0	CUAUACAA	m6b	Disrupted	-0.156000	-0.154000	0.040000
hsa-let-7f-2-3p	tccttCTGTATAagcacct	0	CUAUACAG	m7b	Disrupted	-0.208000	-0.043000	0.190000
hsa-miR-1185-1-3p	tccttCTGTATAagcacct	0	AUAUACAG	m7b	Disrupted	-0.222000	-0.036000	0.860000
hsa-miR-1185-2-3p	tccttCTGTATAagcacct	0	AUAUACAG	m7b	Disrupted	-0.222000	-0.036000	1.330000
hsa-miR-466	tccttcTGTGTAagcacct	1	AUACACAU	m6b	Created	-0.180000	-0.232000	No effect
hsa-miR-4672	tccttCTGTGTAAgcacct	3	UUACACAG	m8a	Created	-0.061000	-0.314000	-0.010000
hsa-miR-4789-5p	tccttcTGTATAagcacct	0	GUAUACAC	m6b	Disrupted	-0.079000	-0.077000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.66810609C>T			COSN15489243		AOCS-135-8-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-340-3p	cagagGAGACGGAtgtgta	0	UCCGUCUC	m8a	Disrupted	-0.943000	-0.479000	0.030000
hsa-miR-4800-3p	cagaggaGACGGATGtgta	0	CAUCCGUC	m8a	Disrupted	-0.336000	no TS	1.540000
hsa-miR-340-3p	cagagGAGACGGAtgtgta	0	UCCGUCUC	m8a	Disrupted	-0.943000	-0.479000	0.030000
hsa-miR-4800-3p	cagaggaGACGGATGtgta	0	CAUCCGUC	m8a	Disrupted	-0.336000	no TS	1.540000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
66804508	rs74211395	G	G	hsa-miR-361-3p	2	gggggTGGGGGAg	Disrupted	N	-0.097
66804508	rs74211395	G	A	hsa-miR-3162-3p hsa-miR-4640-3p hsa-miR-6798-3p	3 3 3	gggGGTAGGGgag GGGGGTAggggag GGGGGTAggggag	Created Created Created	N N N	-0.15 -0.171 -0.237
66804726	rs187142587	T	T	hsa-miR-548l hsa-miR-548n	8 10	tcttgATACTTTt tcttgaTACTTTT	Disrupted Disrupted	N N	0.02 0.024
66804726	rs187142587	T	C	hsa-miR-548az-5p hsa-miR-548t-5p	10 10	tcttgaCACTTTT tcttgaCACTTTT	Created Created	N N	-0.018 -0.018
66804918	rs71983984	-	-	hsa-miR-147a hsa-miR-3151-5p hsa-miR-3911 hsa-miR-4447 hsa-miR-4472 hsa-miR-491-5p hsa-miR-644a hsa-miR-6742-5p hsa-miR-6751-5p hsa-miR-6752-5p hsa-miR-6796-5p hsa-miR-6803-5p hsa-miR-6835-5p hsa-miR-6842-5p hsa-miR-6867-5p hsa-miR-7110-5p	21 21 6 6 6 21 21 21 6 3 21 6 6 3 3 3	ccacccCCACACAca ccacCCCCACAcaca ccacccCCACACAca ccaCCCCCACAcaca ccaCCCCCACAcaca ccacCCCCACAcaca ccacccCCACACAca ccacCCCCACAcaca ccACCCCCAcacaca cCACCCCCAcacaca ccacCCCCACAcaca ccACCCCCAcacaca ccACCCCCAcacaca cCACCCCCAcacaca ccaccccCACACACA cCACCCCCAcacaca	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N N N N N N N	0.002 -0.094 -0.038 -0.299 -0.299 -0.082 -0.029 -0.091 -0.015 -0.116 -0.071 0.029 -0.117 -0.116 -0.043 -0.118
66804918	rs71983984	-	CA	hsa-miR-1275 hsa-miR-3147 hsa-miR-328-5p hsa-miR-4425 hsa-miR-4665-5p hsa-miR-6795-5p hsa-miR-6885-5p hsa-miR-6887-5p hsa-miR-7109-5p	21 21 6 6 21 6 6 6 6	ccacCCCCCAAcacaca ccacccCCCAACAcaca ccaCCCCCCAacacaca ccacccCCCAACAcaca ccacCCCCCAAcacaca ccaCCCCCCAacacaca ccaCCCCCCAacacaca ccaCCCCCCAacacaca ccaCCCCCCAAcacaca	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N	-0.1 -0.05 -0.148 -0.036 -0.096 -0.148 -0.141 -0.155 -0.272
66807247	rs184390193	G	G	hsa-miR-1539 hsa-miR-3193 hsa-miR-4706 hsa-miR-4734 hsa-miR-4749-5p hsa-miR-542-5p hsa-miR-744-5p	2 2 1 1 1 1 1	atcccCGCAGGAc atcccCGCAGGAc aTCCCCGCAggac atcCCCGCAGgac aTCCCCGCAggac ATCCCCGcaggac atCCCCGCAggac	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.047 -0.053 -0.176 -0.063 -0.166 -0.04 -0.079
66807247	rs184390193	G	A	hsa-miR-134-3p hsa-miR-1914-5p hsa-miR-3151-5p hsa-miR-4447 hsa-miR-4450 hsa-miR-4472 hsa-miR-491-5p hsa-miR-6742-5p hsa-miR-6796-5p hsa-miR-6857-5p	1 2 1 1 1 1 1 1 1 1	atcCCCACAGgac atcccCACAGGAc atCCCCACAggac atCCCCACAggac ATCCCCAcaggac atCCCCACAggac aTCCCCACAggac atCCCCACAggac atCCCCACAggac ATCCCCAcaggac	Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N	0.065 0.058 -0.005 0.012 -0.035 0.012 -0.028 -0.005 -0.007 0.058
66807672	rs146410425	A	A	hsa-miR-2115-5p hsa-miR-3180-5p hsa-miR-520a-5p hsa-miR-525-5p	2 2 2 2	tcTGGAAGCctgg TCTGGAAgcctgg TCTGGAAgcctgg TCTGGAAgcctgg	Disrupted Disrupted Disrupted Disrupted	N N N N	0.072 0.123 -0.013 -0.017
66807672	rs146410425	A	G	hsa-miR-4650-5p	1	tctggAGGCCTGg	Created	N	0.072
66807767	rs112811905	G	G	hsa-miR-3667-3p hsa-miR-665 hsa-miR-6734-3p	1 1 1	cttcctGGAAGGA ctTCCTGGAagga cttcctGGAAGGA	Disrupted Disrupted Disrupted	N N N	0.075 0.055 0.07
66807767	rs112811905	G	A	hsa-miR-1237-3p hsa-miR-1248 hsa-miR-4476 hsa-miR-6868-3p hsa-miR-6876-5p	1 1 1 1 1	cttcctAGAAGGA cttcctAGAAGGA CTTCCTAgaagga cttcctAGAAGGA CTTCCTAgaagga	Created Created Created Created Created	N N N N N	0.091 0.089 0.111 0.083 0.104
66808319	rs200043364	C	C	hsa-miR-873-5p	1	tttGTTCCTGttt	Disrupted	N	-0.061
66808319	rs200043364	C
66808320	rs201161411	C	C	hsa-miR-873-5p	1	ttGTTCCTGtttt	Disrupted	N	-0.061
66808320	rs201161411	C
66808321	rs10650691	-	-	hsa-miR-873-5p	1	tttGTTCCTGttttttt	Unknown	N	-0.061
66808321	rs10650691	-	TTT
66808322	rs201192758	G	G	hsa-miR-873-5p	1	GTTCCTGtttttt	Disrupted	N	-0.061
66808322	rs201192758	G
66808338	rs200260592	C	C	hsa-miR-338-3p hsa-miR-4530 hsa-miR-545-3p hsa-miR-548p hsa-miR-6512-3p hsa-miR-6720-5p	11 11 3 3 12 12	ttttTGCTGGAat ttttTGCTGGAat ttTTTGCTGgaat tTTTTGCTggaat tttttGCTGGAAt tttttGCTGGAAt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.052 -0.04 0.006 0.056 -0.056 -0.042
66808338	rs200260592	C	T	hsa-miR-3065-5p	3	ttTTTGTTGgaat	Created	N	0.041
66808645	rs116326339	A	A	hsa-miR-2355-3p hsa-miR-3667-3p hsa-miR-6734-3p hsa-miR-676-3p hsa-miR-6780b-3p	1 3 3 1 1	ggaAGGACAAggg GGAAGGAcaaggg GGAAGGAcaaggg ggaAGGACAAggg ggaaggACAAGGG	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	0.085 0.014 0.065 0.06 0.034
66808645	rs116326339	A	T	hsa-miR-192-5p hsa-miR-215-5p hsa-miR-4780 hsa-miR-6759-3p	1 1 1 1	ggaAGGTCAAggg ggaAGGTCAAggg ggaaggTCAAGGG ggAAGGTCAaggg	Created Created Created Created	N N N N	0.036 0.036 0.051 0.057
66808751	rs9915869	C	C	hsa-miR-1285-3p hsa-miR-196a-3p hsa-miR-3187-5p hsa-miR-5189-5p hsa-miR-612 hsa-miR-661 hsa-miR-6860 hsa-miR-939-3p	1 1 1 1 1 1 1 1	ttgtTGCCCAGgc tTGTTGCCcaggc ttgtTGCCCAGgc ttgtTGCCCAGgc ttgtTGCCCAGgc ttgttgCCCAGGC ttgtTGCCCAGgc ttgttGCCCAGGc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.047 -0.012 -0.019 No Change No Change 0.004 -0.019 -0.012
66808751	rs9915869	C	T	hsa-miR-1254 hsa-miR-3116 hsa-miR-3529-3p hsa-miR-3690 hsa-miR-4638-3p	1 1 1 1 1	ttgttgTCCAGGC ttgttgTCCAGGC TTGTTGTccaggc ttgttGTCCAGGc ttgtTGTCCAGgc	Created Created Created Created Created	N N N N N	-0.021 -0.012 0.156 -0.035 0.013
66809094	rs113741334	A	A	hsa-miR-1273h-5p hsa-miR-149-3p hsa-miR-30b-3p hsa-miR-3689a-3p hsa-miR-3689b-3p hsa-miR-3689c hsa-miR-4728-5p hsa-miR-6779-5p hsa-miR-6780a-5p hsa-miR-6785-5p hsa-miR-6799-5p hsa-miR-6871-5p hsa-miR-6883-5p hsa-miR-7106-5p	1 1 1 1 1 1 1 1 1 1 1 2 1 1	CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg CCTCCCAtttggg cCTCCCATttggg CCTCCCAtttggg CCTCCCAtttggg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N	-0.036 0.01 -0.045 -0.026 -0.026 -0.026 0.007 -0.026 -0.082 0.003 -0.013 0.03 0.007 -0.012
66809094	rs113741334	A	T	hsa-miR-1321 hsa-miR-4739 hsa-miR-4756-5p	1 1 1	CCTCCCTtttggg CCTCCCTtttggg CCTCCCTtttggg	Created Created Created	N N N	-0.056 -0.047 -0.037
66809175	rs76485445	T	C	hsa-miR-210-3p	0	acctgACGCACAc	Created	N	-0.039
66809175	rs76485445	T	T	hsa-miR-4711-5p hsa-miR-7112-3p	0	acCTGATGCAcac accTGATGCAcac	Disrupted Disrupted	N N	0.019 0.02
66809254	rs9895357	G	G	hsa-miR-4671-5p hsa-miR-6734-3p	4 4	tTCTTCGGgaagg ttcttcGGGAAGG	Disrupted Disrupted	N N	-0.069 -0.004
66809254	rs9895357	G	A	hsa-miR-1200 hsa-miR-3140-5p hsa-miR-3185 hsa-miR-3667-3p hsa-miR-378a-5p	21 7 1 1 21	ttctTCAGGAAgg ttcTTCAGGAagg TTCTTCAggaagg ttcttcAGGAAGG ttctTCAGGAAgg	Created Created Created Created Created	N N N N N	0.044 0.041 0.143 0.03 0.048
66809876	rs61013687	A	A	hsa-miR-5193 hsa-miR-5196-3p hsa-miR-660-3p	5 21 3	agGAGGAGGAtgc aggagGAGGATGc AGGAGGAggatgc	Disrupted Disrupted Disrupted	N N N	-0.164 -0.033 -0.097
66809876	rs61013687	A	T	hsa-miR-1306-5p	5	aGGAGGTGgatgc	Created	N	-0.13
66810424	rs9902742	A	A	hsa-miR-548p hsa-miR-6516-3p hsa-miR-96-3p	6 7 9	TTTGCTAcatgat tttgcTACATGAt tttgctACATGAT	Disrupted Disrupted Disrupted	N N N	-0.086 -0.11 -0.15
66810424	rs9902742	A	C	hsa-miR-2681-3p hsa-miR-490-5p hsa-miR-6081	9 7 5	tttgctCCATGAT tttgcTCCATGAt ttTGCTCCAtgat	Created Created Created	N N N	-0.193 -0.124 -0.156

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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

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