SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_206907
Gene Symbol:	PRKAA1
Description:	Homo sapiens protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1), transcript variant 1, mRNA.
Gene Location:	chr5(-):40759480-40798297
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.40759666T>A			COSN4849891		tumor_4191799		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-141-3p	ccatggatCAGTGTTctga	0	UAACACUG	m7b	Created	no TS	-0.096000	No effect
hsa-miR-200a-3p	ccatggatCAGTGTTctga	0	UAACACUG	m7b	Created	no TS	-0.096000	No effect
hsa-miR-640	ccaTGGATCAgtgttctga	0	AUGAUCCA	m7b	(m6c->m7b)	no TS	-0.135000	-1.710000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.40759734T>C			COSN6297151		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3529-3p	ttttgaTGTTGTagtgaca	2	AACAACAA	m6b	Disrupted	-0.273000	-0.244000	No effect
hsa-miR-3913-3p	tttTGATGTCgtagtgaca	0	AGACAUCA	m7b	(m6c->m7b)	no TS	-0.207000	-0.300000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.40760444C>A			COSN8492777		296_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-21-5p	cgctatATAAGCTgttgtg	0	UAGCUUAU	m7b	Created	-0.049000	-0.058000	No effect
hsa-miR-590-5p	cgctatATAAGCTgttgtg	0	GAGCUUAU	m7b	Created	-0.059000	-0.077000	-0.540000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.40761415T>G			COSN5605475		RK169_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3148	tatatgctTTTTTCCccct	0	UGGAAAAA	m7b	Disrupted	0.104000	-0.065000	No effect
hsa-miR-4261	tatatgctTGTTTCCccct	0	AGGAAACA	m7b	Created	no TS	0.062000	-0.100000
hsa-miR-4422	tatATGCTTTTttccccct	11	AAAAGCAU	m8a	Disrupted	-0.074000	-0.089000	No effect
hsa-miR-4668-5p	tatatgcttTTTTCCCcct	0	AGGGAAAA	m7b	(m7b->m6b)	-0.101000	-0.140000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.40762025G>C			ICGC_77A42C40-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1224-3p	cccaaagtGGTGGGattac	0	CCCCACCU	m6b	Disrupted	-0.085	no TS	No effect
hsa-miR-1255b-2-3p	cccaAAGTGGTgggattac	0	AACCACUU	m7b	Disrupted	-0.095	-0.059	0.57
hsa-miR-1260a	cccaaagtGGTGGGATtac	0	AUCCCACC	m8a	Disrupted	-0.127	no TS	No effect
hsa-miR-1260b	cccaaagtGGTGGGATtac	0	AUCCCACC	m8a	Disrupted	-0.136	no TS	0.86
hsa-miR-4530	cccaaagTGCTGGGattac	0	CCCAGCAG	m7a	Created	NA	NA	-1.1

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
40761107	rs112364555	T	T	hsa-miR-1255b-2-3p	2	aatAAGTGGTcac	Disrupted	N	-0.059
			G	hsa-miR-6846-3p hsa-miR-6859-3p hsa-miR-7973	2 2 6	aataAGGGGTCAc aataaGGGGTCAc aataagGGGTCAC	Created Created Created	N N N	-0.208 -0.114 -0.14

Genome Browser