SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006622
Gene Symbol: PLK2
Description: Homo sapiens polo-like kinase 2 (PLK2), transcript variant 2, mRNA.
Gene Location: chr5(-):57749809-57755913
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.58454295T>C 13_220 SJMB032_D Medulloblastoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-185-5p aatTCTCTCCgttgagagc
 30
 UGGAGAGA m7b (m6c->m7b) no TS -0.217 -2.03
hsa-miR-421 aattctctCTGTTGAgagc
 0 AUCAACAG m7b Disrupted -0.229 -0.073 0.06
hsa-miR-4306 aatTCTCTCCgttgagagc
 30
 UGGAGAGA m7b (m6c->m7b) no TS -0.217 -2.02
hsa-miR-4644 aatTCTCTCCgttgagagc
 30
 UGGAGAGA m7b (m6c->m7b) no TS -0.245 -1.49
hsa-miR-4709-5p aattctctCTGTTGagagc
 0 ACAACAGU m6b Disrupted -0.061 no TS 3.48
hsa-miR-95 aattctctCCGTTGAgagc
 0 UUCAACGG m7b Created no TS -0.294 -1.08

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58454523G>C COSN14776477 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-23a-5p tacagGGAACCCaaaagaa
 0 GGGGUUCC m7b Created no TS -0.502000 -18.670000
hsa-miR-23b-5p tacagGGAACCCAaaagaa
 0 UGGGUUCC m8a Created no TS -0.481000 -16.540000
hsa-miR-3940-5p tacagggAACCCAaaagaa
 0 GUGGGUUG m6b Created no TS -0.150000 No effect
hsa-miR-4507 tacagggAACCCAaaagaa
 0 CUGGGUUG m6b Created no TS -0.150000 No effect
hsa-miR-642b-5p tacAGGGAACCcaaaagaa
 0 GGUUCCCU m8a Created no TS -0.197000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
58454523 rs15009 G G hsa-miR-6815-3p
14
 aggGAAGCCAaaa
 Disrupted
N
 -0.167
C hsa-miR-23a-5p
hsa-miR-23b-5p
hsa-miR-3940-5p
hsa-miR-4507
hsa-miR-642b-5p
hsa-miR-6839-3p
14
14
2
2
14
2
 agGGAACCCAaaa
agGGAACCCAaaa
agggAACCCAAaa
agggAACCCAAaa
AGGGAACccaaaa
agggAACCCAAaa
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.502
-0.481
-0.15
-0.15
-0.197
-0.135

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