SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_024613
Gene Symbol:	PLEKHF2
Description:	Homo sapiens pleckstrin homology domain containing, family F (with FYVE domain) member 2 (PLEKHF2), mRNA.
Gene Location:	chr8(+):96145948-96168913
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.95154919C>G			COSN1370124		HCC137T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-409-5p	acttGTAACCTatgtgcct	0	AGGUUACC	m7a	Disrupted	NA	NA	5.070000
hsa-miR-409-5p	acttGTAACCTatgtgcct	0	AGGUUACC	m7a	Disrupted	NA	NA	5.070000
hsa-miR-409-5p	acttGTAACCTatgtgcct	0	AGGUUACC	m7a	Disrupted	NA	NA	5.07

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.95155608A>G			COSN2299849		RK106_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3664-5p	ttatACAGAGTTgtcatac	0	AACUCUGU	m8a	Created	no TS	-0.160000	-13.490000
hsa-miR-4778-5p	ttatACAGAATTgtcatac	0	AAUUCUGU	m8a	Disrupted	-0.113000	-0.032000	0.010000
hsa-miR-549	ttatacagAGTTGTCAtac	1	UGACAACU	m8a	Created	-0.292000	-0.463000	-1.130000
hsa-miR-3664-5p	ttatACAGAGTTgtcatac	0	AACUCUGU	m8a	Created	no TS	-0.16	-13.49
hsa-miR-4778-5p	ttatACAGAATTgtcatac	2	AAUUCUGU	m8a	Disrupted	-0.113	-0.032	0.01
hsa-miR-549	ttatacagAGTTGTCAtac	0	UGACAACU	m8a	Created	-0.292	-0.463	-1.13

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.95155820T>G			COSN5116848		HX35T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-106a-5p	cagacCACTTTaagtttgg	0	AAAAGUGC	m6b	Disrupted	0.043000	no TS	0.020000
hsa-miR-106b-5p	cagacCACTTTAagtttgg	0	UAAAGUGC	m7a	Disrupted	0.043000	no TS	No effect
hsa-miR-17-5p	cagacCACTTTaagtttgg	0	CAAAGUGC	m6b	Disrupted	0.043000	no TS	0.020000
hsa-miR-20a-5p	cagacCACTTTAagtttgg	0	UAAAGUGC	m7a	Disrupted	0.043000	no TS	0.010000
hsa-miR-20b-5p	cagacCACTTTaagtttgg	0	CAAAGUGC	m6b	Disrupted	0.043000	no TS	0.060000
hsa-miR-3609	cagacCACTTTaagtttgg	0	CAAAGUGA	m6b	Disrupted	0.042000	no TS	0.010000
hsa-miR-4796-3p	cagaCCACTTTAagtttgg	0	UAAAGUGG	m8a	Disrupted	-0.066000	no TS	0.030000
hsa-miR-519d	cagacCACTTTaagtttgg	0	CAAAGUGC	m6b	Disrupted	0.033000	no TS	1.790000
hsa-miR-526b-3p	cagacCACTTTaagtttgg	0	GAAAGUGC	m6b	Disrupted	0.036000	no TS	0.650000
hsa-miR-548ah-5p	cagacCACTTTaagtttgg	0	AAAAGUGA	m6b	Disrupted	0.039000	no TS	0.010000
hsa-miR-600	cagaccaCTGTAAGTttgg	0	ACUUACAG	m8a	Created	-0.081000	-0.166000	-0.580000
hsa-miR-93-5p	cagacCACTTTaagtttgg	0	CAAAGUGC	m6b	Disrupted	0.043000	no TS	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
95154858	rs111831010	A	A	hsa-miR-200a-5p hsa-miR-200b-5p hsa-miR-600	2 2 2	aaatGTAAGATtc aaatGTAAGATtc aaaTGTAAGAttc	Disrupted Disrupted Disrupted	N N N	-0.14 -0.149 -0.077
			C	hsa-miR-3660 hsa-miR-4526 hsa-miR-6719-3p hsa-miR-6730-3p	2 2 2 2	aaaTGTCAGAttc aaaTGTCAGAttc aaATGTCAGAttc aaaTGTCAGAttc	Created Created Created Created	N N N N	-0.124 -0.11 -0.309 -0.127
95156076	rs143361961	C	C	hsa-miR-1276 hsa-miR-4311 hsa-miR-5586-3p hsa-miR-583	2 2 5 2	ttcaCTCTTTAct ttcaCTCTTTAct tTCACTCTttact ttcaCTCTTTAct	Disrupted Disrupted Disrupted Disrupted	N N N N	0.002 0.015 -0.171 0.004
			T	hsa-miR-3609 hsa-miR-548ah-5p hsa-miR-548az-5p hsa-miR-548t-5p	5 5 5 5	tTCACTTTttact tTCACTTTttact ttCACTTTTtact ttCACTTTTtact	Created Created Created Created	N N N N	-0.111 -0.092 -0.062 -0.062

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