SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006226
Gene Symbol: PLCL1
Description: Homo sapiens phospholipase C-like 1 (PLCL1), mRNA.
Gene Location: chr2(+):198669425-199014608
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147018C>G 0_111 Lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3529-3p tttctcaTTGTTGTTttct
 0 AACAACAA m8a Created -0.124 -0.295 -1.02

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147460T>C COSN8277027 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3161 aagccaaatTTATCAaagc
 0 CUGAUAAG m6b Disrupted -0.278000 -0.249000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147639T>C COSN6163219 RK111_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1200 atcaatttTCAGGAagttt
 0 CUCCUGAG m6b Created no TS -0.105000 -0.020000
hsa-miR-3140-5p atcaattTTCAGGaagttt
 0 ACCUGAAU m6b Created no TS -0.101000 -0.400000
hsa-miR-378a-5p atcaatttTCAGGAagttt
 0 CUCCUGAC m6b Created no TS -0.094000 -0.270000
hsa-miR-5009-3p atcaattTTTAGGAagttt
 0 UCCUAAAU m7a Disrupted -0.122000 -0.070000 0.510000
hsa-miR-548c-3p atcaATTTTTaggaagttt
 2
 CAAAAAUC m6b Disrupted 0.549000 0.418000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147671A>G COSN9302744 AOCS-116-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4717-3p actaaaCATGTGatttcac
 0 ACACAUGG m6b Created no TS -0.071000 -0.570000
hsa-miR-5007-3p actaaaCATATGATttcac
 9
 AUCAUAUG m8a Disrupted -0.096000 0.047000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147772C>A COSN6680100 CHC322T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130a-5p ttgATGTGAAaataatatt
 0 UUCACAUU m7a (m6a->m7a) no TS -0.044000 -0.710000
hsa-miR-5096 ttgatGTGAAAataatatt
 2
 GUUUCACC m6b Created -0.007000 -0.019000 No effect
hsa-miR-5701 ttgatgtGACAATAAtatt
 4
 UUAUUGUC m8a Disrupted -0.136000 no TS 3.150000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147804A>G COSN1817581 RK133_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1260a gagatttGTGGGAaggtct
 0 AUCCCACC m6b Created -0.227000 -0.308000 No effect
hsa-miR-1260b gagatttGTGGGAaggtct
 0 AUCCCACC m6b Created -0.237000 -0.314000 -0.030000
hsa-miR-1283 gagaTTTGTAGgaaggtct
 1
 UCUACAAA m7b Disrupted -0.116000 -0.101000 No effect
hsa-miR-155-3p gagattTGTAGGAaggtct
 4
 CUCCUACA m7b Disrupted -0.219000 no TS 0.150000
hsa-miR-188-3p gagattTGTGGGAaggtct
 4
 CUCCCACA m7b Created -0.071000 -0.287000 -0.040000
hsa-miR-3156-3p gagatttGTGGGAaggtct
 4
 CUCCCACU m6b Created -0.074000 -0.170000 -0.020000
hsa-miR-3667-3p gagatttgtAGGAAGGTct
 5
 ACCUUCCU m8a (m8a->m7b) -0.116000 no TS No effect
hsa-miR-3685 gagatttGTAGGAAggtct
 4
 UUUCCUAC m7b Disrupted -0.082000 no TS 0.010000
hsa-miR-4719 gagATTTGTGggaaggtct
 5
 UCACAAAU m7b (m6b->m7b) 0.018000 0.064000 -0.020000
hsa-miR-1260a gagatttGTGGGAaggtct
 0 AUCCCACC m6b Created -0.227 -0.308 No effect
hsa-miR-1260b gagatttGTGGGAaggtct
 0 AUCCCACC m6b Created -0.237 -0.314 -0.03
hsa-miR-1283 gagaTTTGTAGgaaggtct
 5
 UCUACAAA m7b Disrupted -0.116 -0.101 No effect
hsa-miR-155-3p gagattTGTAGGAaggtct
 4
 CUCCUACA m7b Disrupted -0.219 no TS 0.15
hsa-miR-188-3p gagattTGTGGGAaggtct
 0 CUCCCACA m7b Created -0.071 -0.287 -0.04
hsa-miR-3156-3p gagatttGTGGGAaggtct
 0 CUCCCACU m6b Created -0.074 -0.17 -0.02
hsa-miR-3667-3p gagatttgtAGGAAGGTct
 0 ACCUUCCU m8a (m8a->m7b) -0.116 no TS No effect
hsa-miR-3685 gagatttGTAGGAAggtct
 4
 UUUCCUAC m7b Disrupted -0.082 no TS 0.01
hsa-miR-4719 gagATTTGTGggaaggtct
 0 UCACAAAU m7b (m6b->m7b) 0.018 0.064 -0.02

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198147808A>C COSN9871087 C0059T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3667-3p tttgtAGGAAGGTctcatt
 5
 ACCUUCCU m8a Disrupted -0.116000 no TS 0.010000
hsa-miR-3685 tttGTAGGAAggtctcatt
 4
 UUUCCUAC m7b (m7b->m6b) -0.082000 no TS 0.010000
hsa-miR-769-5p tttgtaggaAGGTCTCAtt
 3
 UGAGACCU m8a (m8a->m7b) -0.246000 -0.103000 -0.100000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.198148283G>T 9_105036 CRC-9-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1251 aaacCTAGAGaagataatt
 13
 ACUCUAGC m6b Disrupted -0.042 no TS 6.14
hsa-miR-4684-5p aaaccTAGAGAagataatt
 13
 CUCUCUAC m6b Disrupted -0.086 -0.12 No effect
hsa-miR-517-5p aaacCTAGAGaagataatt
 13
 CCUCUAGA m6b Disrupted -0.029 no TS No effect
hsa-miR-942 aaacctAGAGAAGAtaatt
 12
 UCUUCUCU m8a Disrupted -0.024 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr2:g.198148516A>C COSN7156590 8031121 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr2:g.198148579A>G COSN1817582 RK075_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr2:g.198148828G>C COSN1817583 RK046_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3909 ggaAGAGGACAtaaaggat
 0 UGUCCUCU m8a Created no TS -0.207000 No effect
hsa-miR-4279 ggaaGAGGAGAtaaaggat
 1
 CUCUCCUC m7b Disrupted -0.096000 no TS No effect
hsa-miR-3909 ggaAGAGGACAtaaaggat
 0 UGUCCUCU m8a Created no TS -0.207 No effect
hsa-miR-4279 ggaaGAGGAGAtaaaggat
 1
 CUCUCCUC m7b Disrupted -0.096 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
198148113 rs138546507 T T hsa-miR-548c-3p
7
 aggtaATTTTTAc
 Disrupted
N
 0.218
A hsa-miR-4282
5
 aggtAAATTTTAc
 Created
N
 0.293
198149792 rs181017087 G G hsa-miR-1283
hsa-miR-187-5p
hsa-miR-221-3p
hsa-miR-222-3p
hsa-miR-548v
1
1
1
1
1
 TTTGTAGcagggt
tTTGTAGCAgggt
ttTGTAGCAgggt
ttTGTAGCAgggt
ttTGTAGCAgggt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.101
-0.383
-0.152
-0.159
-0.161
A hsa-miR-10a-5p
hsa-miR-10b-5p
hsa-miR-520d-5p
hsa-miR-524-5p
1
1
1
1
 tttgtaACAGGGT
tttgtaACAGGGT
TTTGTAAcagggt
TTTGTAAcagggt
 Created
Created
Created
Created
N
N
N
N
 -0.321
-0.33
-0.013
-0.013

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