SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002631
Gene Symbol: PGD
Description: Homo sapiens phosphogluconate dehydrogenase (PGD), mRNA.
Gene Location: chr1(+):10459084-10480201
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Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.10419766A>C COSN8308741 TCGA-A8-A0A6-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1914-3p gctcctgtcCCCCTCCacg
 0 GGAGGGGU m7a (m6b->m7a) NA NA -6.930000
hsa-miR-4716-3p gctcctgTCCCCCTccacg
 0 AAGGGGGA m7b Created no TS -0.204000 0.010000
hsa-miR-542-3p gctcCTGTCACcctccacg
 3
 UGUGACAG m7b Disrupted 0.000000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10419806C>T COSN8883878 AOCS-147-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-124-3p catGTGCCTTAtggcactg
 0 UAAGGCAC m8a Created no TS -0.402000 -7.150000
hsa-miR-3714 catgTGCCTTatggcactg
 0 GAAGGCAG m6b Created no TS -0.098000 -3.450000
hsa-miR-3910 catgTGCCTTatggcactg
 0 AAAGGCAU m6b Created no TS -0.111000 -1.359000
hsa-miR-4659a-5p catgtgcctCATGGCActg
 2
 CUGCCAUG m7b (m7b->m6c) -0.162000 no TS 1.680000
hsa-miR-4659b-5p catgtgcctCATGGCActg
 2
 UUGCCAUG m7b (m7b->m6c) -0.162000 no TS 1.350000
hsa-miR-506-3p catGTGCCTTAtggcactg
 0 UAAGGCAC m8a Created no TS -0.360000 -4.050000
hsa-miR-5590-5p catgtgcctTATGGCActg
 0 UUGCCAUA m7b (m6c->m7b) no TS -0.143000 -0.800000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
10419763 rs199902976 G G hsa-miR-542-3p
3
 gctcCTGTCACcc
 Disrupted
N
 No Change
T hsa-miR-488-3p
hsa-miR-5681a
hsa-miR-6730-5p
2
2
2
 gctCCTTTCAccc
gctCCTTTCAccc
gctCCTTTCAccc
 Created
Created
Created
N
N
N
 No Change
No Change
No Change

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