SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001197222
Gene Symbol: PDE4D
Description: Homo sapiens phosphodiesterase 4D, cAMP-specific (PDE4D), transcript variant 1, mRNA.
Gene Location: chr5(-):58264865-58335339
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.58969290C>A COSN2111963 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-32-3p aaccctgCTAAATTttctt
 0 CAAUUUAG m7b Created 0.263000 0.231000 -0.190000
hsa-miR-374b-3p aaccCTGCTAAattttctt
 0 CUUAGCAG m7b Created no TS -0.311000 -2.340000
hsa-miR-4282 aaccctgctAAATTTTctt
 18
 UAAAAUUU m7b (m6b->m7b) 0.859000 0.877000 -0.140000
hsa-miR-4468 aaccCTGCTCaattttctt
 1
 AGAGCAGA m6b Disrupted -0.186000 no TS 2.210000
hsa-miR-4524a-5p aaccCTGCTAaattttctt
 0 AUAGCAGC m6b Created no TS -0.152000 No effect
hsa-miR-4524b-5p aaccCTGCTAaattttctt
 0 AUAGCAGC m6b Created no TS -0.148000 No effect
hsa-miR-4690-5p aacCCTGCTCaattttctt
 0 GAGCAGGC m7a (m7a->m6b) no TS -0.202000 -0.550000
hsa-miR-32-3p aaccctgCTAAATTttctt
 0 CAAUUUAG m7b Created 0.263 0.231 -0.21
hsa-miR-374b-3p aaccCTGCTAAattttctt
 0 CUUAGCAG m7b Created no TS -0.311 -2.34
hsa-miR-4282 aaccctgctAAATTTTctt
 0 UAAAAUUU m7b (m6b->m7b) 0.859 0.877 -0.2
hsa-miR-4468 aaccCTGCTCaattttctt
 0 AGAGCAGA m6b Disrupted -0.186 no TS 2.21
hsa-miR-4524a-5p aaccCTGCTAaattttctt
 0 AUAGCAGC m6b Created no TS -0.152 No effect
hsa-miR-4524b-5p aaccCTGCTAaattttctt
 0 AUAGCAGC m6b Created no TS -0.148 No effect
hsa-miR-4690-5p aacCCTGCTCaattttctt
 0 GAGCAGGC m7a (m7a->m6b) no TS -0.202 -0.55

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58969516A>T COSN2111964 RK021_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4330 ttgcATCTGAGttctgaag
 2
 CCUCAGAU m7b Disrupted -0.052000 0.045000 0.440000
hsa-miR-4773 ttgcatctgTGTTCTGaag
 1
 CAGAACAG m7a (m6a->m7a) -0.085000 -0.085000 -0.020000
hsa-miR-5683 ttgCATCTGTgttctgaag
 5
 UACAGAUG m7b (m6c->m7b) 0.104000 0.003000 0.680000
hsa-miR-589-3p ttgcatctgTGTTCTGAag
 2
 UCAGAACA m8a (m7a->m8a) -0.052000 -0.177000 -0.890000
hsa-miR-4330 ttgcATCTGAGttctgaag
 0 CCUCAGAU m7b Disrupted -0.052 0.045 0.44
hsa-miR-4773 ttgcatctgTGTTCTGaag
 0 CAGAACAG m7a (m6a->m7a) -0.085 -0.085 -0.02
hsa-miR-5683 ttgCATCTGTgttctgaag
 0 UACAGAUG m7b (m6c->m7b) 0.104 0.003 0.68
hsa-miR-589-3p ttgcatctgTGTTCTGAag
 0 UCAGAACA m8a (m7a->m8a) -0.052 -0.177 -0.89

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58969881G>C COSN8227468 PCSI_0303_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4529-5p aattacttaGATGGCCTat
 4
 AGGCCAUC m8a (m8a->m7a) -0.296000 -0.018000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58970183T>C COSN14542937 8069331 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p gattATTCTTTtagtggtt
 3
 CAAAGAAU m7b Disrupted 0.543000 0.510000 0.110000
hsa-miR-3123 gattATTCTCTtagtggtt
 0 CAGAGAAU m7b Created 0.064000 0.027000 -0.040000
hsa-miR-3925-5p gattaTTCTCTTagtggtt
 0 AAGAGAAC m7a Created 0.056000 0.056000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58970430C>T COSN6923117 RK077_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181b-3p gtggctttTCAGTGAaagg
 8
 CUCACUGA m7b Disrupted -0.095000 -0.068000 1.060000
hsa-miR-4420 gtggctttTCAGTGAaagg
 8
 GUCACUGA m7b Disrupted -0.094000 -0.077000 0.330000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58971182T>A COSN4851008 tumor_4107137 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4282 tttaaccaAAATTTTcttc
 18
 UAAAAUUU m7b Created 0.859000 1.092000 -0.090000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58971391G>A COSN6923118 RK215_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-21-3p tgggaTGGTGTTGatatat
 2
 CAACACCA m8a Disrupted -0.154000 -0.113000 No effect
hsa-miR-3591-3p tgggaTGGTGTTgatatat
 2
 AAACACCA m7b Disrupted -0.108000 -0.095000 -0.020000
hsa-miR-421 tgggatggTGTTGATatat
 5
 AUCAACAG m7a Disrupted -0.139000 -0.139000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58971523C>T COSN1317541 HX15T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4710 tttttttCTCACCaaatga
 17
 GGGUGAGG m6b Disrupted -0.041000 no TS 0.070000
hsa-miR-4792 tttttttCTCACCaaatga
 17
 CGGUGAGC m6b Disrupted -0.055000 no TS 1.310000
hsa-miR-539-5p ttttTTTCTCaccaaatga
 2
 GGAGAAAU m6b Disrupted 0.095000 no TS No effect
hsa-miR-4710 tttttttCTCACCaaatga
 0 GGGUGAGG m6b Disrupted -0.041 no TS 0.07
hsa-miR-4792 tttttttCTCACCaaatga
 0 CGGUGAGC m6b Disrupted -0.055 no TS 1.31
hsa-miR-539-5p ttttTTTCTCaccaaatga
 0 GGAGAAAU m6b Disrupted 0.095 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr5:g.58972006A>T COSN7948350 8015127 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.58972148C>T COSN1317542 HX17T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-135b-3p ctCCCTACATttagtattt
 4
 AUGUAGGG m8a (m7b->m8a) -0.045000 -0.072000 -1.160000
hsa-miR-4280 ctccCTACACTtagtattt
 4
 GAGUGUAG m7b Disrupted -0.087000 -0.108000 1.050000
hsa-miR-595 ctccctACACTTagtattt
 2
 GAAGUGUG m6b Disrupted 0.094000 no TS 0.140000
hsa-miR-135b-3p ctCCCTACATttagtattt
 0 AUGUAGGG m8a (m7b->m8a) -0.045 -0.072 -1.16
hsa-miR-4280 ctccCTACACTtagtattt
 0 GAGUGUAG m7b Disrupted -0.087 -0.108 1.05
hsa-miR-595 ctccctACACTTagtattt
 0 GAAGUGUG m6b Disrupted 0.094 no TS 0.14

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58972774A>G COSN6923119 RK028_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-34a-3p gtttacCTGATTatagcag
 0 CAAUCAGC m6b Disrupted 0.098000 0.051000 0.250000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58973008C>A COSN7948351 8012341 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1245a gtcctttATCACTTatcct
 2
 AAGUGAUC m7a Disrupted -0.083000 -0.083000 1.610000
hsa-miR-340-5p gtcCTTTATAActtatcct
 3
 UUAUAAAG m8a Created 0.748000 1.057000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58973025T>C COSN5607989 RK125_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-155-3p cacataacgTGTAGGAagt
 0 CUCCUACA m7b (m7b->m6b) 0.034000 0.024000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58973119T>C COSN5607990 RK060_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-551b-5p ttttaaTGATTTCaccatg
 0 GAAAUCAA m7a Disrupted 0.200000 0.200000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58973874A>T COSN2111965 RK031_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p tagtgATTCTTTGtttgtt
 3
 CAAAGAAU m8a Created 0.543000 0.592000 No effect
hsa-miR-186-5p tagtgATTCTTTGtttgtt
 3
 CAAAGAAU m8a Created 0.543000 0.592000 No effect
hsa-miR-186-5p tagtgATTCTTTGtttgtt
 0 CAAAGAAU m8a Created 0.543 0.592 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58973875C>G COSN2111966 RK031_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-15b-3p gtagTGATTCattgtttgt
 6
 CGAAUCAU m6b Disrupted -0.042000 no TS 0.050000
hsa-miR-34b-3p gtAGTGATTGattgtttgt
 4
 CAAUCACU m8a (m7b->m8a) -0.043000 -0.043000 No effect
hsa-miR-4705 gtaGTGATTGAttgtttgt
 0 UCAAUCAC m8a Created no TS -0.238000 -5.330000
hsa-miR-15b-3p gtagTGATTCattgtttgt
 6
 CGAAUCAU m6b Disrupted -0.042000 no TS 0.050000
hsa-miR-34b-3p gtAGTGATTGattgtttgt
 4
 CAAUCACU m8a (m7b->m8a) -0.043000 -0.043000 No effect
hsa-miR-4705 gtaGTGATTGAttgtttgt
 0 UCAAUCAC m8a Created no TS -0.238000 -5.330000
hsa-miR-15b-3p gtagTGATTCattgtttgt
 0 CGAAUCAU m6b Disrupted -0.042 no TS 0.05
hsa-miR-34b-3p gtAGTGATTGattgtttgt
 0 CAAUCACU m8a (m7b->m8a) -0.043 -0.043 No effect
hsa-miR-4705 gtaGTGATTGAttgtttgt
 0 UCAAUCAC m8a Created no TS -0.238 -5.33


Mutation Mutation ID Sample Name Cancer Type
chr5:g.58973961A>G COSN7948352 8047856 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.58974202A>G COSN7948353 8044436 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4284 aggaggaggGTGAGCCaca
 0 GGGCUCAC m7b (m6b->m7b) -0.098000 -0.274000 -2.580000
hsa-miR-4667-3p aggAGGAGGGtgagccaca
 2
 UCCCUCCU m7b (m6c->m7b) -0.044000 -0.183000 -0.870000
hsa-miR-4793-5p aggaggAGGATGagccaca
 1
 ACAUCCUG m6b Disrupted -0.052000 no TS 0.570000
hsa-miR-5193 agGAGGAGGAtgagccaca
 4
 UCCUCCUC m8a (m8a->m7b) -0.377000 -0.207000 No effect
hsa-miR-5196-3p aggagGAGGATGAgccaca
 0 UCAUCCUC m8a Disrupted -0.242000 no TS 0.410000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58974504C>A COSN1317543 HCC16T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-625-3p caggaaTATAGTaaccagt
 0 GACUAUAG m6b Created 0.060000 0.014000 -0.080000
hsa-miR-625-3p caggaaTATAGTaaccagt
 0 GACUAUAG m6b Created 0.06 0.014 -0.08

Mutation Mutation ID Sample Name Cancer Type
chr5:g.58974523G>T COSN6923120 RK220_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1269a gactactCAGTCCAGcgct
 1
 CUGGACUG m8a Disrupted -0.195000 no TS No effect
hsa-miR-1269b gactactCAGTCCAGcgct
 1
 CUGGACUG m8a Disrupted -0.177000 no TS No effect
hsa-miR-3673 gactactCATTCCAgcgct
 0 AUGGAAUG m7b Created no TS -0.120000 -0.010000
hsa-miR-378a-3p gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.201000 no TS 4.440000
hsa-miR-378b gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.154000 no TS 1.560000
hsa-miR-378c gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.201000 no TS 3.060000
hsa-miR-378d gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.201000 no TS 3.360000
hsa-miR-378e gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.201000 no TS 3.510000
hsa-miR-378f gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.154000 no TS 0.300000
hsa-miR-378h gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.192000 no TS 3.090000
hsa-miR-378i gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.201000 no TS 6.880000
hsa-miR-422a gactactcAGTCCAGcgct
 1
 ACUGGACU m7b Disrupted -0.192000 no TS 3.780000
hsa-miR-4515 gactactCAGTCCagcgct
 1
 AGGACUGG m6b Disrupted -0.133000 no TS 3.140000
hsa-miR-4740-5p gactacTCAGTCCagcgct
 2
 AGGACUGA m7b Disrupted -0.366000 -0.019000 0.820000
hsa-miR-613 gactactCATTCCagcgct
 0 AGGAAUGU m6b Created no TS -0.070000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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