SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_013988
Gene Symbol: PARK2
Description: Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 1, mRNA.
Gene Location: chr6(-):161768589-163148834
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.161347619C>A COSN14848100 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.161347671A>C ICGC_BAAC0468-2A78-11E2-9C69-1CFD496BB9B8 CPCG_0103_Pr_P_P3 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-143-5p acgccACTGCACtccagcc
 0 GGUGCAGU m7b Created no TS -0.124 -0.43
hsa-miR-4276 acgcCACTGAactccagcc
 0 CUCAGUGA m6b Disrupted -0.071 -0.013 0.01
hsa-miR-5000-5p acgccaCTGAACTccagcc
 0 CAGUUCAG m7b Disrupted -0.076 no TS 3.65
hsa-miR-5693 acGCCACTGCactccagcc
 0 GCAGUGGC m8a (m7b->m8a) -0.337 -0.142 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161347934C>T COSN6589830 ICGC_MB104 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3653 acagtgaTTCTTAaaataa
 8
 CUAAGAAG m6b Disrupted 0.005000 no TS 0.930000
hsa-miR-3658 acagtgaTTCTTAAAataa
 8
 UUUAAGAA m8a Disrupted -0.072000 no TS 2.390000
hsa-miR-548c-3p acagtGATTTTTaaaataa
 0 CAAAAAUC m7b Created no TS 0.016000 -1.130000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161348762C>T COSN2151175 RK082_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1200 ctgacttCTCAGGAagatc
 5
 CUCCUGAG m7b Disrupted -0.098000 no TS 0.030000
hsa-miR-1253 ctgaCTTCTCaggaagatc
 6
 AGAGAAGA m6b Disrupted 0.049000 no TS No effect
hsa-miR-3653 ctgaCTTCTTAGgaagatc
 8
 CUAAGAAG m8a Created 0.005000 0.077000 -1.800000
hsa-miR-378a-5p ctgacttcTCAGGAagatc
 2
 CUCCUGAC m6b Disrupted -0.124000 -0.115000 0.060000
hsa-miR-4251 ctgacTTCTCAGGaagatc
 3
 CCUGAGAA m8a Disrupted 0.092000 0.059000 No effect
hsa-miR-4324 ctgactTCTCAGGaagatc
 4
 CCCUGAGA m7b Disrupted -0.102000 no TS 1.120000
hsa-miR-4329 ctgactTCTCAGGaagatc
 0 CCUGAGAC m7a Disrupted 0.009000 0.009000 0.110000
hsa-miR-544b ctgacttCTCAGGaagatc
 5
 ACCUGAGG m6b Disrupted -0.018000 no TS 0.090000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161348803A>G COSN14790126 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-323b-5p agagaaagtACAACCacta
 1
 AGGUUGUC m6b Disrupted -0.019000 no TS 0.170000
hsa-miR-3613-5p agagaaaGTACAACcacta
 0 UGUUGUAC m7b Disrupted -0.055000 no TS 2.180000
hsa-miR-4325 agagaAAGTGCAAccacta
 2
 UUGCACUU m8a Created -0.268000 -0.313000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161349011G>T COSN2151176 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1304-3p aagtccCAGTGAGctctgc
 2
 UCUCACUG m7b Created -0.248000 -0.195000 No effect
hsa-miR-3670 aagtcccagTGAGCTCTgc
 1
 AGAGCUCA m8a (m7a->m8a) -0.239000 -0.244000 -0.970000
hsa-miR-4292 aagtCCCAGGGagctctgc
 4
 CCCCUGGG m7b Disrupted -0.189000 no TS 0.180000
hsa-miR-1304-3p aagtccCAGTGAGctctgc
 0 UCUCACUG m7b Created -0.248 -0.195 No effect
hsa-miR-3670 aagtcccagTGAGCTCTgc
 0 AGAGCUCA m8a (m7a->m8a) -0.239 -0.244 -0.97
hsa-miR-4292 aagtCCCAGGGagctctgc
 0 CCCCUGGG m7b Disrupted -0.189 no TS 0.18

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161349079C>T COSN7787055 PCSI_0080_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1268a agaCACGCCCGactctctc
 0 CGGGCGUG m8a Disrupted -0.188000 no TS 1.970000
hsa-miR-1268b agaCACGCCCGactctctc
 0 CGGGCGUG m8a Disrupted -0.188000 no TS 1.820000
hsa-miR-3186-5p agacACGCCTGactctctc
 0 CAGGCGUC m7a Created NA NA -1.380000
hsa-miR-3937 agacaCGCCTGactctctc
 0 ACAGGCGG m6b Created no TS -0.113000 -11.760000
hsa-miR-4750 agacaCGCCCGActctctc
 0 CUCGGGCG m7b Disrupted -0.240000 no TS 0.470000
hsa-miR-4785 agacacgcCCGACTCTctc
 2
 AGAGUCGG m8a Disrupted -0.337000 -0.216000 0.890000
hsa-miR-5702 agacacgcCTGACTCtctc
 0 UGAGUCAG m7b Created no TS -0.006000 -6.450000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161349696A>G COSN6311610 RK119_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-5p tggagagagAGTTCTCAca
 0 UGAGAACU m8a (m8a->m7a) -0.284000 -0.121000 0.280000
hsa-miR-146b-5p tggagagagAGTTCTCAca
 0 UGAGAACU m8a (m8a->m7a) -0.284000 -0.121000 0.300000
hsa-miR-3183 tggAGAGAGGgttctcaca
 2
 GCCUCUCU m7b (m6c->m7b) -0.126000 -0.223000 -0.160000
hsa-miR-4680-5p tggagagAGAGTTCTcaca
 0 AGAACUCU m8a Disrupted -0.168000 -0.068000 1.030000
hsa-miR-4723-3p tggAGAGAGGGttctcaca
 2
 CCCUCUCU m8a Created -0.192000 -0.298000 No effect
hsa-miR-589-5p tggagagagGGTTCTCAca
 0 UGAGAACC m8a (m7a->m8a) -0.297000 -0.501000 -0.790000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161349716G>T COSN15377520 0091_CRUK_PC_0091_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3920 agacaggcaTAATCAGTag
 1
 ACUGAUUA m8a (m7a->m8a) -0.021000 -0.099000 -2.710000
hsa-miR-4633-5p agacAGGCATAatcagtag
 0 AUAUGCCU m7b Created no TS -0.270000 -0.300000
hsa-miR-4727-5p agacaGGCAGAatcagtag
 2
 AUCUGCCA m6b Disrupted -0.118000 no TS 0.010000
hsa-miR-5001-3p agacAGGCAGAAtcagtag
 2
 UUCUGCCU m8a Disrupted -0.286000 no TS 0.090000
hsa-miR-532-5p agacAGGCATaatcagtag
 0 CAUGCCUU m6b Created no TS -0.120000 -1.910000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.161349993G>A 9_72336 CRC-7-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4783-5p cgcgcGCGCGCacacacac
 0 GGCGCGCC m6b Disrupted -0.284 -0.292 No effect
hsa-miR-933 cgcgcgcGCGCACAcacac
 1
 UGUGCGCA m7a Disrupted -0.226 -0.228 -1.03

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
161347669 rs12215397 C C hsa-miR-3135b
hsa-miR-4653-3p
hsa-miR-5000-5p
2
2
2
 actgaaCTCCAGC
actgAACTCCAgc
aCTGAACTccagc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.21
-0.086
-0.076
A hsa-miR-1287-5p
hsa-miR-1290
hsa-miR-205-3p
hsa-miR-30a-3p
hsa-miR-30d-3p
hsa-miR-30e-3p
hsa-miR-3167
hsa-miR-378j
hsa-miR-6839-5p
hsa-miR-876-5p
2
2
2
2
2
2
2
2
2
2
 actgaaATCCAGC
actgAAATCCAgc
aCTGAAATccagc
ACTGAAAtccagc
ACTGAAAtccagc
ACTGAAAtccagc
actGAAATCCAgc
actgaAATCCAGc
actgaAATCCAGc
actGAAATCCAgc
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
 -0.225
-0.01
-0.026
0.019
0.019
0.019
-0.187
-0.101
-0.101
-0.229
161347707 rs200119552 G G hsa-miR-18a-3p
hsa-miR-1913
hsa-miR-324-3p
hsa-miR-4313
hsa-miR-5587-3p
hsa-miR-6840-5p
2
2
2
2
1
1
 cccgggGGGCAGA
cccggGGGGCAGA
cccggGGGGCAGA
cccgGGGGGCAga
CCCGGGGggcaga
cCCGGGGGgcaga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.125
-0.352
-0.342
-0.217
-0.362
-0.301
A hsa-miR-1247-3p
hsa-miR-4532
hsa-miR-5001-3p
hsa-miR-6778-3p
hsa-miR-6791-3p
hsa-miR-6829-3p
hsa-miR-6836-3p
1
1
2
2
2
2
2
 CCCGGGAggcaga
CCCGGGAggcaga
cccgggAGGCAGA
cccGGGAGGCAga
cccgGGAGGCAga
cccgGGAGGCAga
cccgGGAGGCAga
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.21
-0.202
-0.071
-0.385
-0.142
-0.139
-0.148
161348803 rs3734464 A A hsa-miR-323b-5p
hsa-miR-3613-5p
hsa-miR-410-5p
hsa-miR-494-5p
1
0
1
1
 gaaagtACAACCA
gaaaGTACAACca
gaaagtACAACCA
gaaagtACAACCA
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.019
-0.055
-0.019
-0.032
G hsa-miR-4325
hsa-miR-656-5p
hsa-miR-7703
0 gaAAGTGCAAcca
gaaagtGCAACCA
gaaAGTGCAAcca
 Created
Created
Created
N
N
N
 -0.045
-0.063
-0.015

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