SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002564
Gene Symbol:	P2RY2
Description:	Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), transcript variant 2, mRNA.
Gene Location:	chr11(+):72929343-72947395
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.73235369C>G			COSN1542512		RK052_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3144-5p	cgccacagtGTCCCCagat	0	AGGGGACC	m6b	Created	no TS	-0.173000	1.100000
hsa-miR-3150a-3p	cgccacagtCTCCCCAGat	5	CUGGGGAG	m8a	(m8a->m7b)	-0.220000	no TS	0.610000
hsa-miR-3175	cgccacagTCTCCCCagat	5	CGGGGAGA	m7b	Disrupted	-0.368000	no TS	No effect
hsa-miR-4318	cgCCACAGTGtccccagat	0	CACUGUGG	m8a	(m7a->m8a)	-0.139000	-0.139000	-0.250000
hsa-miR-4652-5p	cgccacagtGTCCCCagat	0	AGGGGACU	m6b	Created	no TS	-0.181000	-0.020000
hsa-miR-873-3p	cgccaCAGTCTCCccagat	1	GGAGACUG	m8a	Disrupted	-0.220000	-0.084000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.73235574A>T			COSN1137625		HCC134T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4661-5p	ctcccatGCTAGTagctgg	0	AACUAGCU	m6b	Created	no TS	-0.112000	No effect
hsa-miR-5011-3p	ctcCCATGCAagtagctgg	2	GUGCAUGG	m7b	(m7b->m6b)	-0.255000	no TS	0.010000
hsa-miR-4661-5p	ctcccatGCTAGTagctgg	0	AACUAGCU	m6b	Created	no TS	-0.112	No effect
hsa-miR-5011-3p	ctcCCATGCAagtagctgg	2	GUGCAUGG	m7b	(m7b->m6b)	-0.255	no TS	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.73235619T>A			10_16502		6408		Breast cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3929	agtcCAGCCTaatcaagtc	6	GAGGCUGA	m6b	Disrupted	-0.123	0	1.52
hsa-miR-4419b	agtcCAGCCTaatcaagtc	6	GAGGCUGA	m6b	Disrupted	-0.12	0	3.84
hsa-miR-4430	agTCCAGCCTaatcaagtc	3	AGGCUGGA	m8a	(m8a->m7a)	-0.287	-0.436	No effect
hsa-miR-4478	agtcCAGCCTaatcaagtc	6	GAGGCUGA	m6b	Disrupted	-0.116	0	3.65
hsa-miR-4505	agtCCAGCCTaatcaagtc	4	AGGCUGGG	m7a	(m7a->m6a)	-0.244	-0.383	-2.09
hsa-miR-647	agtcCAGCCAaatcaagtc	6	GUGGCUGC	m6b	Created	no TS	-0.139	-0.03

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
73235986	rs184775232	A	A	hsa-miR-138-5p hsa-miR-4299	6 4	gctttCACCAGCc gcttTCACCAGcc	Disrupted Disrupted	N N	-0.187 -0.13
			C	hsa-miR-2110 hsa-miR-3153 hsa-miR-4271 hsa-miR-4505 hsa-miR-4667-5p hsa-miR-4700-5p hsa-miR-4725-3p hsa-miR-4731-5p hsa-miR-5787 hsa-miR-6733-5p hsa-miR-6739-5p hsa-miR-6780b-5p hsa-miR-8089	3 2 3 8 4 4 3 6 8 2 2 3 4	gctTTCCCCAgcc gCTTTCCCcagcc gctTTCCCCAgcc gctttcCCCAGCC gcttTCCCCAGcc gcttTCCCCAGcc gctTTCCCCAgcc gctttCCCCAGCc gctttcCCCAGCC gCTTTCCCcagcc gCTTTCCCcagcc gctTTCCCCAgcc gcttTCCCCAGcc	Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N	-0.1 -0.035 -0.062 -0.208 -0.16 -0.142 -0.059 -0.188 -0.208 -0.044 -0.026 -0.062 -0.142

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