SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_198074
Gene Symbol: OR2C3
Description: Homo sapiens olfactory receptor, family 2, subfamily C, member 3 (OR2C3), mRNA.
Gene Location: chr1(-):247693433-247697141
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.247530391A>G COSN7214612 8036161 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548p ttttgTTTTGCTtatctat
 0 UAGCAAAA m7b Created -0.307000 -0.425000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr1:g.247530527T>G COSN1101659 HCC122T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr1:g.247530602G>A COSN7470017 tumor_4135099 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302c-5p ctgatacATGTTAAAatta
 2
 UUUAACAU m8a Disrupted -0.203000 -0.102000 0.510000
hsa-miR-3143 ctgatacATGTTAaaatta
 2
 AUAACAUU m6b Disrupted -0.086000 -0.071000 2.920000
hsa-miR-3924 ctgATACATATtaaaatta
 0 AUAUGUAU m8a Created no TS -0.076000 No effect
hsa-miR-4517 ctgataCATATTaaaatta
 2
 AAAUAUGA m6b Created -0.060000 -0.071000 No effect
hsa-miR-5583-3p ctgataCATATTaaaatta
 0 GAAUAUGG m6b Created no TS -0.017000 -0.610000
hsa-miR-889 ctgatacATATTAAaatta
 0 UUAAUAUC m7a Created no TS 0.026000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.247530935C>A COSN5370101 RK169_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1231 gacCCAGACAaagaccgcg
 0 GUGUCUGG m7b (m6c->m7b) no TS -0.123000 -2.270000
hsa-miR-4288 gaccCAGACAAagaccgcg
 0 UUGUCUGC m7a Created no TS 0.001000 -2.170000
hsa-miR-4527 gaccCAGACCAagaccgcg
 2
 UGGUCUGC m7a Disrupted -0.253000 -0.208000 3.130000
hsa-miR-632 gaccCAGACAaagaccgcg
 0 GUGUCUGC m6b Created no TS -0.016000 -10.860000


Mutation Mutation ID Sample Name Cancer Type
chr1:g.247531196G>A COSN7214613 8031146 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr1:g.247531424G>A COSN7470018 tumor_4120193 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10b-3p tggaAATCTGaaaggagtg
 5
 ACAGAUUC m6b Disrupted -0.062000 no TS 2.450000
hsa-miR-376a-5p tggaAATCTAaaaggagtg
 0 GUAGAUUC m6b Created no TS -0.051000 -7.100000
hsa-miR-3942-3p tggaaATCTGAAAggagtg
 3
 UUUCAGAU m8a Disrupted -0.201000 no TS 0.850000
hsa-miR-4760-5p tggaAATCTAAAaggagtg
 2
 UUUAGAUU m8a Created -0.019000 -0.193000 -0.112000
hsa-miR-5100 tggaaATCTGAAaggagtg
 3
 UUCAGAUC m7a Disrupted -0.077000 no TS 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.247531437T>A COSN8637975 J36_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-141-5p agctcaaGGAAGATGgaaa
 2
 CAUCUUCC m8a Created -0.216000 -0.395000 -6.100000
hsa-miR-3200-3p agctCAAGGTagatggaaa
 5
 CACCUUGC m6b Disrupted -0.145000 no TS 9.180000
hsa-miR-502-5p agctCAAGGAagatggaaa
 0 AUCCUUGC m6b Created no TS -0.102000 -0.680000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.247531447G>A COSN8637976 360_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-27b-5p atattgttTAAGCTCaagg
 0 AGAGCUUA m7b Created no TS -0.422000 -0.210000
hsa-miR-302a-5p atattGTTTAAGctcaagg
 0 ACUUAAAC m7b Created no TS -0.123000 -0.720000
hsa-miR-3670 atattgttTGAGCTCaagg
 3
 AGAGCUCA m7b Disrupted -0.436000 no TS No effect
hsa-miR-371a-5p atattGTTTGAGctcaagg
 4
 ACUCAAAC m7b Disrupted -0.130000 -0.002000 1.760000
hsa-miR-590-5p atattgttTAAGCTCaagg
 0 GAGCUUAU m7a Created NA NA -2.980000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.247531459C>G COSN1441361 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3185 gtttTTCTTCTaatattgt
 0 AGAAGAAG m7a Disrupted NA NA 0.010000
hsa-miR-5197-3p gttttTCTTCTaatattgt
 0 AAGAAGAG m6b Disrupted -0.126000 -0.031000 No effect
hsa-miR-3185 gtttTTCTTCTaatattgt
 0 AGAAGAAG m7a Disrupted NA NA 0.01
hsa-miR-5197-3p gttttTCTTCTaatattgt
 0 AAGAAGAG m6b Disrupted -0.126 -0.031 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.247531482G>T COSN8637977 J36_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146b-3p gaagACAGGGCActtggga
 1
 UGCCCUGU m8a Disrupted -0.428000 no TS 4.640000
hsa-miR-339-5p gaaGACAGGGcacttggga
 1
 UCCCUGUC m7b (m7b->m6c) -0.275000 no TS 13.090000
hsa-miR-371b-3p gaagacaGGGCACTTggga
 1
 AAGUGCCC m8a Disrupted -0.288000 no TS 4.850000
hsa-miR-4421 gaAGACAGGTcacttggga
 1
 ACCUGUCU m8a (m7b->m8a) -0.210000 -0.238000 1.340000
hsa-miR-631 gaagaCAGGTCacttggga
 0 AGACCUGG m6b Created no TS -0.154000 -0.040000
hsa-miR-874 gaagaCAGGGCActtggga
 1
 CUGCCCUG m7b Disrupted -0.279000 no TS 2.300000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
247530602 rs73146580 G G hsa-miR-302c-5p
hsa-miR-3143
hsa-miR-552-5p
2
2
2
 atacATGTTAAAa
atacATGTTAAaa
atacatGTTAAAA
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.101
-0.015
0.013
A hsa-miR-3924
hsa-miR-4517
hsa-miR-5583-3p
hsa-miR-889-3p
1
1
1
2
 ATACATAttaaaa
ataCATATTAaaa
ataCATATTAaaa
atacATATTAAaa
 Created
Created
Created
Created
N
N
N
N
 -0.076
-0.011
-0.017
0.026
247531457 rs73148444 A A hsa-miR-16-2-3p
hsa-miR-195-3p
hsa-miR-5197-3p
3
3
1
 tcttctAATATTG
tcttctAATATTG
TCTTCTAatattg
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.056
-0.056
-0.095
G hsa-miR-2115-3p
hsa-miR-3074-3p
hsa-miR-361-5p
1
2
1
 tcTTCTGATAttg
tcttCTGATATtg
tctTCTGATAttg
 Created
Created
Created
N
N
N
 -0.244
-0.157
-0.158
247531483 rs141481931 G G hsa-miR-146b-3p
hsa-miR-3173-5p
hsa-miR-339-5p
hsa-miR-371b-3p
hsa-miR-4421
hsa-miR-5699-3p
hsa-miR-6799-3p
hsa-miR-7976
hsa-miR-874-3p
1
1
1
1
1
1
1
1
1
 agACAGGGCActt
agaCAGGGCActt
aGACAGGGcactt
agacaGGGCACTt
AGACAGGgcactt
AGACAGGgcactt
agaCAGGGCActt
agaCAGGGCActt
agaCAGGGCActt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.428
-0.182
-0.275
-0.288
-0.21
-0.182
-0.185
-0.187
-0.279
A hsa-miR-302a-3p
hsa-miR-302b-3p
hsa-miR-302c-3p
hsa-miR-302d-3p
hsa-miR-302e
hsa-miR-3120-5p
hsa-miR-3194-3p
hsa-miR-372-3p
hsa-miR-373-3p
hsa-miR-520a-3p
hsa-miR-520b
hsa-miR-520c-3p
hsa-miR-520d-3p
hsa-miR-520e
hsa-miR-5691
hsa-miR-6805-3p
hsa-miR-6888-3p
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
 agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
AGACAGAgcactt
agaCAGAGCActt
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agacagAGCACTT
agaCAGAGCActt
agaCAGAGCActt
AGACAGAgcactt
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
 -0.113
-0.113
-0.113
-0.113
-0.113
-0.08
-0.136
-0.103
-0.103
-0.113
-0.103
-0.103
-0.122
-0.103
-0.215
-0.205
-0.144

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