SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_000912
Gene Symbol:	OPRK1
Description:	Homo sapiens opioid receptor, kappa 1 (OPRK1), mRNA.
Gene Location:	chr8(-):54138275-54164194
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53225724A>G			COSN2279754		RK170_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-367-5p	ctgaaaatcGCAACAGTc	0	ACUGUUGC	m8a	(m7a->m8a)	no TS	-0.213000	-0.240000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53226404G>A			COSN8090538		8058339		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4655-3p	ggtcctaACGAGGGgtcag	1	ACCCUCGU	m7b	Disrupted	-0.217000	no TS	8.720000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53226405C>T			COSN6600640		ICGC_MB104		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1258	aggTCCTAACgaggggtca	1	AGUUAGGA	m7b	(m7b->m6c)	0.004000	0.046000	0.020000
hsa-miR-4655-3p	aggtcctaACGAGGGgtca	1	ACCCUCGU	m7b	Disrupted	-0.217000	no TS	1.720000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53226568T>C			COSN6518810		HX36T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-144-5p	tctcTGATATCtctcattt	2	GGAUAUCA	m7b	Disrupted	-0.018000	-0.025000	2.250000
hsa-miR-202-3p	tctctgATACCTCTcattt	0	AGAGGUAU	m8a	Created	no TS	-0.038000	-4.030000
hsa-miR-3074-3p	tctCTGATATCtctcattt	1	GAUAUCAG	m8a	Disrupted	-0.084000	-0.065000	0.890000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53226938C>T			COSN8090539		8031544		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-141-3p	ctcttaCAGTGTTAattgc	0	UAACACUG	m8a	Created	no TS	-0.034000	-0.010000
hsa-miR-200a-3p	ctcttaCAGTGTTAattgc	0	UAACACUG	m8a	Created	no TS	-0.044000	-0.750000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53227044C>G			COSN9660294		AOCS-135-3-1		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4256	actcctgacGTCAGAatat	3	AUCUGACC	m6b	Created	-0.079000	-0.079000	-0.020000
hsa-miR-4649-3p	actcctgaCCTCAGAatat	1	UCUGAGGC	m7a	Disrupted	-0.208000	-0.241000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53227141G>A			COSN8090540		8015259		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-216a	aagtagcTGAGATTAcagg	6	UAAUCUCA	m8a	Created	-0.168000	0.028000	-1.400000
hsa-miR-216b	aagtagctGAGATTacagg	0	AAAUCUCU	m6b	Created	no TS	0.126000	-0.850000
hsa-miR-4733-5p	aagtagcTGGGATTacagg	0	AAUCCCAA	m7a	Disrupted	NA	NA	0.150000
hsa-miR-5690	aaGTAGCTGAgattacagg	1	UCAGCUAC	m8a	(m7b->m8a)	-0.085000	-0.120000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53227172G>A			COSN7673822		PCSI_0078_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273e	ggtTCAAGCAAttctcctg	0	UUGCUUGA	m8a	Created	no TS	-0.034000	-5.840000
hsa-miR-2964a-3p	ggttcaaGCAATTCTcctg	0	AGAAUUGC	m8a	Created	no TS	0.054000	-0.020000
hsa-miR-302f	ggttcaAGCAATTctcctg	0	UAAUUGCU	m7b	Created	no TS	0.128000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53227827C>T			0_317				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3158-3p	tatatAGCCCTatgtaact	6	AAGGGCUU	m6b	Disrupted	-0.149	-0.058	2.41
hsa-miR-4446-3p	tatatAGCCCTatgtaact	6	CAGGGCUG	m6b	Disrupted	-0.065	no TS	0.03
hsa-miR-5088	tatatAGCCCTatgtaact	6	CAGGGCUC	m6b	Disrupted	-0.095	no TS	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53227945G>A			COSN2279755		RK052_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-885-5p	gagGTAATGGctttttctg	0	UCCAUUAC	m7b	(m7b->m6c)	0.022000	no TS	0.920000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228235C>G			COSN4940560		PD4115a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-454-5p	aacatATAGGGattcgcag	0	ACCCUAUC	m6b	Created	no TS	-0.067000	-2.970000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228331T>G			COSN8858261		SS6003149		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-219-1-3p	gctcaCAACTCatgtgcta	1	AGAGUUGA	m6b	Disrupted	-0.024000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228332C>G			COSN8090541		8068600		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-219-1-3p	tgctcaCAACTCatgtgct	1	AGAGUUGA	m6b	Disrupted	-0.024000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228531T>C			COSN2279756		RK035_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3924	aaatatATACATAgtatct	0	AUAUGUAU	m7b	Created	no TS	-0.044000	-0.010000
hsa-miR-5011-5p	aaataTATATATAgtatct	2	UAUAUAUA	m8a	Disrupted	0.579000	0.525000	0.010000
hsa-miR-568	aaataTATACATagtatct	0	AUGUAUAA	m7a	Created	NA	NA	-0.010000
hsa-miR-625-3p	aaatatataTATAGTatct	0	GACUAUAG	m6b	Disrupted	-0.040000	no TS	No effect
hsa-miR-3924	aaatatATACATAgtatct	0	AUAUGUAU	m7b	Created	no TS	-0.044	-0.01
hsa-miR-5011-5p	aaataTATATATAgtatct	0	UAUAUAUA	m8a	Disrupted	0.579	0.525	0.01
hsa-miR-568	aaataTATACATagtatct	0	AUGUAUAA	m7a	Created	NA	NA	-0.01
hsa-miR-625-3p	aaatatataTATAGTatct	0	GACUAUAG	m6b	Disrupted	-0.04	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228562A>G			COSN5683479		RK057_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228620A>C			COSN6600641		ICGC_MB110		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4639-5p	ttttttCTTAGCAtgctat	3	UUGCUAAG	m7b	Disrupted	-0.166000	no TS	6.420000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53228854G>A			COSN14744096		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1267	acctcCAACAGaatgggaa	0	CCUGUUGA	m6b	Created	no TS	-0.067000	-1.390000
hsa-miR-1468	acctccAACGGAatgggaa	1	CUCCGUUU	m6b	Disrupted	-0.147000	no TS	6.550000
hsa-miR-367-5p	acctcCAACAGaatgggaa	0	ACUGUUGC	m6b	Created	no TS	-0.074000	-0.040000
hsa-miR-4652-3p	acctccAACAGAAtgggaa	0	GUUCUGUU	m7b	Created	no TS	0.039000	-0.230000
hsa-miR-4778-5p	acctccaACAGAATgggaa	1	AAUUCUGU	m7b	Created	0.103000	0.067000	-0.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.53229103A>T			COSN8519119		J74_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3131	aaaagGTCCTCGcaacaca	0	UCGAGGAC	m7b	Created	no TS	-0.265000	-0.050000
hsa-miR-4535	aaaAGGTCCACgcaacaca	0	GUGGACCU	m8a	Disrupted	-0.228000	no TS	0.030000
hsa-miR-4737	aaaaggtCCTCGCAacaca	0	AUGCGAGG	m7b	Created	no TS	-0.541000	-3.270000
hsa-miR-4751	aaaaGGTCCTCgcaacaca	0	AGAGGACC	m7b	Created	no TS	-0.259000	-6.410000
hsa-miR-4800-5p	aaaaGGTCCACgcaacaca	0	AGUGGACC	m7b	Disrupted	-0.257000	no TS	2.090000
hsa-miR-611	aaaagGTCCTCGCaacaca	0	GCGAGGAC	m8a	Created	no TS	-0.265000	-4.510000
hsa-miR-659-5p	aaAAGGTCCTcgcaacaca	0	AGGACCUU	m8a	(m7b->m8a)	-0.388000	-0.217000	0.160000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
53225771	rs191507215	C
53225771	rs191507215	C	T	hsa-miR-5011-5p	3	TATATATgattgt	Created	N	-0.057
53226404	rs200067073	G	G	hsa-miR-4655-3p hsa-miR-6795-3p	1 2	cctaACGAGGGgt cctaaCGAGGGGt	Disrupted Disrupted	N N	-0.217 -0.201
53226404	rs200067073	G	A	hsa-miR-1258 hsa-miR-6780b-3p	1 1	CCTAACAaggggt cctaACAAGGGgt	Created Created	N N	-0.111 -0.112
53226405	rs201124611	C	C	hsa-miR-1258 hsa-miR-4655-3p hsa-miR-6795-3p	1 1 2	TCCTAACgagggg tcctaACGAGGGg tcctaaCGAGGGG	Disrupted Disrupted Disrupted	N N N	-0.042 -0.217 -0.201
53226405	rs201124611	C
53226590	rs199704813	A	A	hsa-miR-193b-5p hsa-miR-4520a-3p hsa-miR-4520b-3p hsa-miR-4529-3p hsa-miR-7850-5p	2 3 1 1 1	ttgtccAAACCCC tTGTCCAAacccc tTGTCCAAAcccc ttGTCCAAAcccc ttGTCCAAAcccc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.036 -0.046 -0.152 -0.045 -0.033
53226590	rs199704813	A	T	hsa-miR-1197 hsa-miR-1258 hsa-miR-3117-3p	3 1 1	tTGTCCTAacccc ttgTCCTAACccc ttGTCCTAAcccc	Created Created Created	N N N	-0.042 -0.017 -0.06
53227023	rs201878596	G	G	hsa-miR-6089	1	tgcctCGGCCTCc	Disrupted	N	-0.069
53227023	rs201878596	G	A	hsa-miR-1827 hsa-miR-3929 hsa-miR-4419b hsa-miR-4478 hsa-miR-4649-3p hsa-miR-485-5p hsa-miR-6884-5p hsa-miR-7160-5p	0	TGCCTCAgcctcc tgccTCAGCCTcc tgccTCAGCCTcc tgccTCAGCCTcc tGCCTCAGcctcc tgcctCAGCCTCc tgcctCAGCCTCc tgCCTCAGCctcc	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.055 0.064 0.064 0.045 -0.002 -0.023 -0.06 0.011
53227036	rs181250246	A	A	hsa-miR-4778-5p	1	CAGAATAttcacc	Disrupted	N	0.103
53227036	rs181250246	A	G	hsa-miR-543	2	caGAATGTTcacc	Created	N	0.14
53227148	rs201836328	G	G	hsa-miR-374c-3p hsa-miR-5690	1 2	tcCTAAGTAgctg tcctaaGTAGCTG	Disrupted Disrupted	N N	0.097 0.028
53227148	rs201836328	G	A	hsa-miR-651-5p	1	TCCTAAAtagctg	Created	N	0.09
53227329	rs200452553	A	A	hsa-miR-3927-5p hsa-miR-500a-5p	2 1	GATAGGAttatga gatAGGATTAtga	Disrupted Disrupted	N N	-0.017 0.045
53227329	rs200452553	A	G	hsa-miR-454-5p hsa-miR-652-5p hsa-miR-6732-3p	2 1 1	GATAGGGttatga gaTAGGGTTAtga gatAGGGTTAtga	Created Created Created	N N N	-0.108 -0.041 -0.007
53227543	rs201286776	A	A	hsa-miR-340-5p hsa-miR-935	2 3	TTTATAActgaat tttaTAACTGAat	Disrupted Disrupted	N N	0.184 0.039
53227543	rs201286776	A	G	hsa-miR-5690	3	tttaTAGCTGAat	Created	N	-0.012
53227656	rs201143020	C	C	hsa-miR-1258 hsa-miR-3152-3p hsa-miR-6800-5p hsa-miR-6802-5p	6 4 6 6	tggcaCCTAACAc tggcacCTAACAC tggCACCTAAcac tggCACCTAAcac	Disrupted Disrupted Disrupted Disrupted	N N N N	0.046 0.008 0.018 0.014
53227656	rs201143020	C	T	hsa-miR-302a-3p hsa-miR-302b-3p hsa-miR-302c-3p hsa-miR-302d-3p hsa-miR-302e hsa-miR-372-3p hsa-miR-373-3p hsa-miR-519a-3p hsa-miR-519b-3p hsa-miR-519c-3p hsa-miR-520a-3p hsa-miR-520b hsa-miR-520c-3p hsa-miR-520d-3p hsa-miR-520e	4 4 4 4 4 4 4 4 4 4 4 4 4 4 4	tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac tgGCACTTAacac	Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N N N	0.031 0.031 0.031 0.031 0.031 0.034 0.034 0.017 0.017 0.017 0.031 0.034 0.034 0.034 0.037
53227657	rs202096269	C	C	hsa-miR-1258 hsa-miR-6800-5p hsa-miR-6802-5p	6 6 6	atggcaCCTAACA atggCACCTAAca atggCACCTAAca	Disrupted Disrupted Disrupted	N N N	0.046 0.018 0.014
53227657	rs202096269	C
53227835	rs200798830	A	A	hsa-miR-190a-3p hsa-miR-4272 hsa-miR-5011-5p hsa-miR-6074	2 1 2 2	ttgaATATATAgc TTGAATAtatagc ttgaATATATAgc tTGAATATAtagc	Disrupted Disrupted Disrupted Disrupted	N N N N	0.175 0.084 0.206 0.09
53227835	rs200798830	A	G	hsa-miR-1284 hsa-miR-181a-5p hsa-miR-181b-5p hsa-miR-181c-5p hsa-miR-181d-5p hsa-miR-4262	2 2 2 2 2 2	ttgaaTGTATAGc tTGAATGTAtagc tTGAATGTAtagc tTGAATGTAtagc tTGAATGTAtagc tTGAATGTAtagc	Created Created Created Created Created Created	N N N N N N	0.018 0.049 0.049 0.049 0.049 0.049
53227948	rs201283976	A	A	hsa-miR-4777-3p hsa-miR-885-5p	10 10	GAGGTAAtggctt gagGTAATGGctt	Disrupted Disrupted	N N	-0.03 0.022
53227948	rs201283976	A	G	hsa-miR-4999-3p	10	gaGGTAGTGgctt	Created	N	-0.09
53228439	rs3802280	C	C	hsa-miR-144-5p hsa-miR-6798-5p	3 12	TGATATCccctga tgatatCCCCTGA	Disrupted Disrupted	N N	-0.025 -0.121
53228439	rs3802280	C	T	hsa-miR-211-3p hsa-miR-4270 hsa-miR-4441 hsa-miR-6754-5p	12 12 12 12	tgatatTCCCTGA tgatatTCCCTGA tgatatTCCCTGA tgatatTCCCTGA	Created Created Created Created	N N N N	-0.082 -0.066 -0.072 -0.069
53228529	rs201861707	T	T	hsa-miR-190a-3p hsa-miR-5011-5p hsa-miR-625-3p	1 1 1	tATATATAgtatc TATATATAgtatc tataTATAGTAtc	Disrupted Disrupted Disrupted	N N N	-0.043 0.004 -0.04
53228529	rs201861707	T	G	hsa-miR-5684	1	tataTAGAGTAtc	Created	N	-0.081
53228537	rs200924104	T	T	hsa-miR-190a-3p hsa-miR-5011-5p	21 2	tgaaaATATATAt tgaaaaTATATAT	Disrupted Disrupted	N N	-0.037 0.032
53228537	rs200924104	T	A	hsa-miR-335-3p	2	TGAAAAAatatat	Created	N	0.049
53228623	rs200455045	C	C	hsa-miR-4639-5p	3	ttttttCTTAGCA	Disrupted	N	-0.166
53228623	rs200455045	C
53228854	rs191864454	G	G	hsa-miR-1468-5p	21	tccAACGGAAtgg	Disrupted	N	-0.147
53228854	rs191864454	G	A	hsa-miR-1267 hsa-miR-367-5p hsa-miR-4652-3p hsa-miR-4778-5p	21 21 21 21	tcCAACAGAatgg tcCAACAGAatgg tccAACAGAAtgg tccaACAGAATgg	Created Created Created Created	N N N N	-0.067 -0.074 0.039 -0.036
53229101	rs193018670	G	G	hsa-miR-6821-5p hsa-miR-6853-5p	2 2	gtCCACGCAAcac gtCCACGCAacac	Disrupted Disrupted	N N	-0.506 -0.222
53229101	rs193018670	G	A	hsa-miR-147a hsa-miR-3138 hsa-miR-3911 hsa-miR-4800-5p hsa-miR-644a hsa-miR-6818-5p	2 1 2 1 2 2	gtCCACACAAcac GTCCACAcaacac gTCCACACAacac GTCCACAcaacac gtCCACACAacac gtcCACACAAcac	Created Created Created Created Created Created	N N N N N N	-0.348 -0.172 -0.318 -0.222 -0.136 -0.088
53229102	rs199577564	C	C	hsa-miR-4800-5p hsa-miR-6821-5p hsa-miR-6853-5p	2 2 2	GGTCCACgcaaca ggtCCACGCAAca ggtCCACGCAaca	Disrupted Disrupted Disrupted	N N N	-0.257 -0.506 -0.222
53229102	rs199577564	C	T	hsa-miR-4666b hsa-miR-4684-3p hsa-miR-5011-3p	2 2 2	ggtcCATGCAAca ggtccaTGCAACA ggtCCATGCAAca	Created Created Created	N N N	-0.127 -0.095 -0.344
53229108	rs200631270	G	G	hsa-miR-4535 hsa-miR-4800-5p hsa-miR-492 hsa-miR-659-5p hsa-miR-6759-3p hsa-miR-6861-3p	2 2 2 2 2 2	acaaaAGGTCCAc acaaaaGGTCCAC acaaaAGGTCCAc acaaAAGGTCCAc acaAAAGGTCcac acaaaAGGTCCAc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.228 -0.257 -0.164 -0.388 -0.142 -0.177
53229108	rs200631270	G	A	hsa-miR-5009-5p hsa-miR-8058	2 2	acaaaAAGTCCAc acaaaAAGTCCAc	Created Created	N N	-0.168 -0.206

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser