SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_016828
Gene Symbol:	OGG1
Description:	Homo sapiens 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a, mRNA.
Gene Location:	chr3(+):9791627-9808353
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9765878C>T			ICGC_1311394		TCGA-AP-A0LM-01A-11D-A122-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3689d	gatCACCTCCgagaaggcc	0	GGGAGGUG	m7b	(m7b->m6b)	-0.21	no TS	2.28
hsa-miR-3917	gatcaccTCCGAGaaggcc	0	GCUCGGAC	m6b	Disrupted	-0.204	no TS	0.01
hsa-miR-4257	gatcACCTCTGagaaggcc	0	CCAGAGGU	m7b	Created	no TS	-0.314	-4.58
hsa-miR-4330	gatcaccTCTGAGaaggcc	0	CCUCAGAU	m6b	Created	no TS	-0.087	-5.39

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9765970C>A			ICGC_1311395		TCGA-AX-A0J0-01A-11D-A117-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273d	ctATGGGTTCtgtgaccac	0	GAACCCAU	m8a	(m8a->m7a)	-0.154	-0.327	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9765974G>C			cosmic_v64_1474872		Serous		Ovarian
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3545-5p	gggttctgtGACCACTgct	0	UAGUGGUC	m7b	(m7b->m6c)	-0.189	no TS	-0.01
hsa-miR-542-3p	gggttCTGTCACcactgct	0	UGUGACAG	m7b	Created	no TS	-0.174	-5.97
hsa-miR-5587-5p	gggttctGTGACCActgct	0	AUGGUCAC	m7b	Disrupted	-0.174	no TS	No effect
hsa-miR-3545-5p	gggttctgtGACCACTgct	0	UAGUGGUC	m7b	(m7b->m6c)	-0.189000	no TS	-0.010000
hsa-miR-542-3p	gggttCTGTCACcactgct	0	UGUGACAG	m7b	Created	no TS	-0.174000	-5.970000
hsa-miR-5587-5p	gggttctGTGACCActgct	0	AUGGUCAC	m7b	Disrupted	-0.174000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9766007C>T			ICGC_ssm_v3_12148		BN28T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-149-3p	gatgaCCCTCCCctagtca	0	AGGGAGGG	m7b	Disrupted	-0.192	no TS	0.01
hsa-miR-3202	gatgaCCCTTCCctagtca	0	UGGAAGGG	m7b	Created	no TS	-0.162	No effect
hsa-miR-4728-5p	gatgaCCCTCCCctagtca	0	UGGGAGGG	m7b	Disrupted	-0.21	no TS	No effect
hsa-miR-4747-5p	gatgacCCTTCCCTagtca	0	AGGGAAGG	m8a	Created	no TS	-0.153	No effect
hsa-miR-5196-5p	gatgacCCTTCCCTagtca	0	AGGGAAGG	m8a	Created	no TS	-0.135	No effect
hsa-miR-5584-5p	gatgacccTTCCCTagtca	0	CAGGGAAA	m6b	Created	-0.069	-0.126	0.15

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
9765878	rs200472416	C	C	hsa-miR-3689d hsa-miR-3917 hsa-miR-6851-5p	2 4 2	CACCTCCgagaag caccTCCGAGAag CACCTCCgagaag	Disrupted Disrupted Disrupted	N N N	-0.21 -0.204 -0.21
			T	hsa-miR-4257 hsa-miR-4330 hsa-miR-6847-5p	4 4 4	cACCTCTGAgaag caccTCTGAGAag caCCTCTGAgaag	Created Created Created	N N N	-0.314 -0.087 -0.103

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