SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_016819
Gene Symbol:	OGG1
Description:	Homo sapiens 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a, mRNA.
Gene Location:	chr3(+):9791627-9799089
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9757083A>A			ICGC_64062		TCGA-GD-A3OS-01A-12D-A21Z-08		BladderUrothelialCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-143-5p	ccgacCTGCACCaatcccg	0	GGUGCAGU	m7a	Created	NA	NA	-0.4
hsa-miR-509-3p	ccgacctgcACCAATCccg	0	UGAUUGGU	m7b	(m6c->m7b)	no TS	-0.041	-2.17

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9757124A>G			ICGC_1311387		TCGA-AP-A054-01A-11W-A062-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3183	aagcgcAGAGAGGgttcca	0	GCCUCUCU	m7b	Created	no TS	-0.066	-1.57
hsa-miR-4723-3p	aagcgcAGAGAGGGttcca	0	CCCUCUCU	m8a	Created	no TS	-0.066	-5.34
hsa-miR-544a	aagcGCAGAAagggttcca	0	AUUCUGCA	m6b	Disrupted	-0.039	no TS	-0.77

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.9757338C>T			COSN7769444		ASHPC_0003_Pa_P_2		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5682	gggagacaGTGCTAaggat	0	GUAGCACC	m6b	Created	no TS	-0.128000	No effect
hsa-miR-626	gggAGACAGCgctaaggat	3	AGCUGUCU	m7b	(m7b->m6b)	-0.162000	no TS	2.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
9757119	rs193147996	G	G	hsa-miR-191-3p hsa-miR-544a hsa-miR-6738-3p	9 9 9	caaAGCGCAGAaa caaagcGCAGAAA caaagcGCAGAAA	Disrupted Disrupted Disrupted	N N N	-0.483 -0.039 -0.041
			A	hsa-miR-1251-3p hsa-miR-218-5p hsa-miR-4652-3p hsa-miR-4743-3p hsa-miR-5008-3p hsa-miR-636 hsa-miR-6737-3p hsa-miR-6889-3p hsa-miR-7157-3p	12 13 13 13 9 13 9 9 9	CAAAGCAcagaaa caAAGCACAgaaa caaagcACAGAAA caaagcACAGAAA caaAGCACAGAaa caAAGCACAgaaa caaAGCACAGAaa caaaGCACAGAaa caaAGCACAGAaa	Created Created Created Created Created Created Created Created Created	N N N N N N N N N	-0.153 -0.093 0.017 -0.012 -0.322 -0.051 -0.301 -0.114 -0.322

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