SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001025434
Gene Symbol:	NQO1
Description:	Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1, mRNA.
Gene Location:	chr16(-):69743303-69760533
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.69710066T>G			ICGC_D455DF9C-2A78-11E2-951E-21FD496BB9B8		CPCG_0103_Pr_P_P5		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3165	caggcgtgATCCACCacac	0	AGGUGGAU	m7b	Disrupted	-0.187	no TS	-0.11
hsa-miR-4284	caggcGTGAGCCaccacac	0	GGGCUCAC	m7b	Created	no TS	-0.176	-0.89

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.69710284G>A			ICGC_401533		TCGA-AA-3510-01A-01D-1408-10		ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-144-5p	tggtgTGATATCggctcac	0	GGAUAUCA	m7b	Created	no TS	0.013	-0.02

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.69710363T>C			COSN7269424		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1255a	gcagTCATCCacttttttt	0	AGGAUGAG	m6b	Created	no TS	-0.120000	-5.360000
hsa-miR-1255b-5p	gcagTCATCCacttttttt	0	CGGAUGAG	m6b	Created	no TS	-0.120000	-6.660000
hsa-miR-3681-5p	gcagtcATCCACTtttttt	0	UAGUGGAU	m7b	Created	no TS	-0.198000	-1.180000
hsa-miR-3691-5p	gcagtCATCCACTtttttt	6	AGUGGAUG	m8a	Created	-0.222000	-0.450000	-0.070000
hsa-miR-4796-3p	gcagtcatCCACTTTtttt	0	UAAAGUGG	m7b	Created	no TS	-0.152000	No effect
hsa-miR-548n	gcagtcatcTACTTTTttt	0	CAAAAGUA	m7b	(m7b->m6b)	-0.021000	no TS	-0.010000
hsa-miR-548t-5p	gcagtcatcCACTTTTttt	0	CAAAAGUG	m7b	(m6b->m7b)	no TS	-0.053000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.69710800T>C			COSN6092835		RK181_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1245a	tcttatGATCACTatcatg	0	AAGUGAUC	m7b	Created	no TS	-0.394000	-0.160000
hsa-miR-154-3p	tctTATGATTactatcatg	5	AAUCAUAC	m7a	(m7a->m6b)	-0.108000	-0.108000	No effect
hsa-miR-487a	tctTATGATTactatcatg	5	AAUCAUAC	m7a	(m7a->m6b)	-0.101000	-0.101000	-0.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
69709741	rs34906225	T	T	hsa-miR-1 hsa-miR-206 hsa-miR-3673 hsa-miR-613	1 1 1 1	atctCATTCCAct atctCATTCCAct atctCATTCCAct atctCATTCCAct	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.075 -0.075 -0.147 -0.085
			A	hsa-miR-3681-5p hsa-miR-4461 hsa-miR-6849-5p hsa-miR-8056	2 1 2 1	atctcaATCCACT aTCTCAATccact atctcaATCCACT atctcAATCCACt	Created Created Created Created	N N N N	-0.22 -0.1 -0.211 -0.17
69709921	rs147078767	A	A	hsa-miR-142-5p hsa-miR-548a-5p hsa-miR-548ab hsa-miR-548ak hsa-miR-548am-5p hsa-miR-548ap-5p hsa-miR-548aq-5p hsa-miR-548ar-5p hsa-miR-548as-5p hsa-miR-548au-5p hsa-miR-548av-5p hsa-miR-548ay-5p hsa-miR-548b-5p hsa-miR-548c-5p hsa-miR-548d-5p hsa-miR-548h-5p hsa-miR-548i hsa-miR-548j-5p hsa-miR-548k hsa-miR-548l hsa-miR-548o-5p hsa-miR-548w hsa-miR-548y hsa-miR-559 hsa-miR-5590-3p hsa-miR-8054	4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4	tACTTTATttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg TACTTTAtttctg tACTTTATttctg TACTTTAtttctg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N N N N N N N N N N	-0.057 -0.009 -0.026 -0.009 -0.009 -0.009 -0.016 -0.009 -0.009 -0.009 -0.026 -0.019 -0.019 -0.009 -0.019 -0.012 -0.012 -0.009 -0.026 -0.029 -0.009 -0.009 -0.016 -0.006 -0.094 -0.03
			T	hsa-miR-548n	4	TACTTTTtttctg	Created	N	-0.131

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