SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001164749
Gene Symbol: NPAS3
Description: Homo sapiens neuronal PAS domain protein 3 (NPAS3), transcript variant 1, mRNA.
Gene Location: chr14(+):33408458-34273382
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr14:g.33801355G>T COSN8588572 522_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1228-3p ctaAGGTGTGtgttgggtt
 1
 UCACACCU m7b (m7b->m6b) -0.175000 no TS 3.190000
hsa-miR-3065-5p ctaaggtgTTTGTTGggtt
 13
 UCAACAAA m7b Created 0.125000 0.108000 -2.510000
hsa-miR-495 ctaaggtGTTTGTTgggtt
 20
 AAACAAAC m7b Created 0.173000 0.181000 -0.360000
hsa-miR-5688 ctaaggtGTTTGTTgggtt
 20
 UAACAAAC m7b Created 0.166000 0.137000 -5.130000


Mutation Mutation ID Sample Name Cancer Type
chr14:g.33801598T>G COSN7227716 8057482 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr14:g.33801863A>G COSN8828409 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-361-3p tttTGGGGGAaaaaaaaaa
 2
 UCCCCCAG m7a (m7a->m6a) -0.139000 no TS No effect
hsa-miR-3679-3p ttttGGGGGAAaaaaaaaa
 2
 CUUCCCCC m7b Disrupted -0.774000 -0.719000 No effect
hsa-miR-4446-5p ttttggGGGAAAaaaaaaa
 2
 AUUUCCCU m6b Disrupted -0.035000 -0.025000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33801953C>T COSN7227717 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-3p cgttTGCTGCaggacttaa
 0 AGCAGCAU m6b Disrupted -0.621000 -0.531000 0.310000
hsa-miR-107 cgttTGCTGCaggacttaa
 0 AGCAGCAU m6b Disrupted -0.621000 -0.531000 0.090000
hsa-miR-1184 cgtttGCTGCAGGacttaa
 19
 CCUGCAGC m8a Disrupted -0.295000 -0.116000 2.340000
hsa-miR-155-3p cgtttgcTGTAGGActtaa
 0 CUCCUACA m7b Created no TS -0.096000 -5.010000
hsa-miR-3120-3p cgtTTGCTGTaggacttaa
 0 CACAGCAA m7b (m6b->m7b) no TS -0.104000 -1.330000
hsa-miR-3158-5p cgtttgCTGCAGGacttaa
 0 CCUGCAGA m7a Disrupted NA NA 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33802650G>T COSN6247081 RK211_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p aatgtagtTTTTTTGTcct
 10
 ACAAAAAA m8a Created 0.016000 0.207000 -0.040000
hsa-miR-548ae aatgtAGTTTTTttgtcct
 21
 CAAAAACU m7b Created 0.063000 0.167000 -3.610000
hsa-miR-548ah-3p aatgtAGTTTTTttgtcct
 21
 CAAAAACU m7b Created 0.063000 0.176000 -1.130000
hsa-miR-548aj-3p aatgtAGTTTTTttgtcct
 21
 UAAAAACU m7b Created 0.063000 0.167000 -4.570000
hsa-miR-548am-3p aatgtAGTTTTTttgtcct
 21
 CAAAAACU m7b Created 0.063000 0.176000 -2.520000
hsa-miR-548aq-3p aatgtAGTTTTTttgtcct
 21
 CAAAAACU m7b Created 0.063000 0.167000 -4.190000
hsa-miR-548x-3p aatgtAGTTTTTttgtcct
 21
 UAAAAACU m7b Created 0.063000 0.167000 -4.520000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33802863C>T COSN6247082 RK212_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-5p atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.008000 no TS 1.330000
hsa-let-7b-5p atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.036000 no TS 0.010000
hsa-let-7c atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.018000 no TS 1.050000
hsa-let-7d-5p atattctccCTACCTCTcc
 3
 AGAGGUAG m8a (m8a->m7b) 0.027000 no TS 1.370000
hsa-let-7e-5p atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.008000 no TS 2.390000
hsa-let-7f-5p atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.008000 no TS 1.450000
hsa-let-7g-5p atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.008000 no TS 1.080000
hsa-let-7i-5p atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.036000 no TS 0.970000
hsa-miR-1321 atattCTCCCTacctctcc
 7
 CAGGGAGG m6b Disrupted -0.020000 -0.023000 0.320000
hsa-miR-3162-5p atattCTCCCTAcctctcc
 2
 UUAGGGAG m7b Disrupted -0.040000 no TS 2.720000
hsa-miR-3173-3p atattCTCCTTacctctcc
 0 AAAGGAGG m6b Created no TS 0.036000 0.080000
hsa-miR-4428 atatTCTCCTTacctctcc
 19
 CAAGGAGA m7b Created -0.007000 -0.032000 -0.270000
hsa-miR-4458 atattctccCTACCTCTcc
 3
 AGAGGUAG m8a (m8a->m7b) -0.001000 no TS 0.270000
hsa-miR-4500 atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.036000 no TS 0.210000
hsa-miR-4739 atattCTCCCTacctctcc
 7
 AAGGGAGG m6b Disrupted -0.044000 -0.051000 0.370000
hsa-miR-4756-5p atattCTCCCTacctctcc
 7
 CAGGGAGG m6b Disrupted -0.002000 0.005000 0.310000
hsa-miR-98 atattctccCTACCTCtcc
 3
 UGAGGUAG m7b (m7b->m6c) 0.018000 no TS 2.070000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33803955G>C COSN8341257 0006_CRUK_PC_0006_T4_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125b-1-3p aagcTAACCCGacctaact
 0 ACGGGUUA m7b Created no TS -0.445000 -7.210000
hsa-miR-431-3p aagctaaccCGACCTaact
 0 CAGGUCGU m6b Created no TS -0.251000 -5.240000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
33801603 rs143021748 G G hsa-miR-3679-3p
hsa-miR-3938
hsa-miR-6731-3p
2
6
5
 ataGGGGGAAtag
ataggGGGAATAg
atagggGGAATAG
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.298
-0.125
-0.144
A hsa-miR-26a-1-3p
hsa-miR-26a-2-3p
hsa-miR-4287
hsa-miR-4469
hsa-miR-454-5p
hsa-miR-4685-3p
hsa-miR-4713-5p
hsa-miR-629-3p
hsa-miR-6867-3p
hsa-miR-6883-3p
hsa-miR-7113-3p
5
5
2
2
3
2
2
2
2
3
2
 atagggAGAATAG
atagggAGAATAG
atAGGGAGAatag
atAGGGAGAatag
ATAGGGAgaatag
atAGGGAGAatag
ataGGGAGAAtag
ataGGGAGAAtag
atAGGGAGAAtag
ATAGGGAgaatag
atAGGGAGAatag
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
 -0.109
-0.109
-0.158
-0.164
-0.161
-0.165
-0.175
-0.262
-0.406
-0.205
-0.15

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