SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002514
Gene Symbol:	NOV
Description:	Homo sapiens nephroblastoma overexpressed gene (NOV), mRNA.
Gene Location:	chr8(+):120428551-120436678
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.119423920A>T			COSN6909601		RK077_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-320e	agaaaCAGCTTattagcag	0	AAAGCUGG	m6b	Created	no TS	-0.086000	-10.860000
hsa-miR-4517	agaaacagCATATTagcag	2	AAAUAUGA	m6b	Disrupted	-0.027000	-0.065000	0.490000
hsa-miR-4728-3p	agaaaCAGCATattagcag	1	CAUGCUGA	m6b	Disrupted	-0.097000	no TS	6.880000
hsa-miR-5583-3p	agaaacagCATATTagcag	1	GAAUAUGG	m6b	Disrupted	0.029000	no TS	1.445000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.119424247G>A			COSN8574577		tumor_4166706		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4795-5p	acgtgttCCACTTCTctct	0	AGAAGUGG	m8a	Created	no TS	-0.213000	-0.490000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.119424375G>C			COSN2258053		RK148_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3973	tatTACTTTGgtgcataaa	4	ACAAAGUA	m7b	(m7b->m6b)	-0.316000	-0.192000	2.890000
hsa-miR-500a-3p	tattactttGGTGCATaaa	0	AUGCACCU	m7a	(m7a->m6b)	NA	NA	6.290000
hsa-miR-501-3p	tattactttGGTGCATaaa	1	AAUGCACC	m7b	(m7b->m6c)	-0.522000	-0.190000	3.130000
hsa-miR-502-3p	tattactttGGTGCATaaa	1	AAUGCACC	m7b	(m7b->m6c)	-0.522000	-0.190000	3.110000
hsa-miR-548aq-5p	taTTACTTTCgtgcataaa	1	GAAAGUAA	m8a	(m7a->m8a)	-0.171000	-0.171000	-0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
119424368	rs138474585	T	T	hsa-miR-374c-5p hsa-miR-548a-5p hsa-miR-548ab hsa-miR-548ak hsa-miR-548am-5p hsa-miR-548ap-5p hsa-miR-548aq-5p hsa-miR-548ar-5p hsa-miR-548as-5p hsa-miR-548au-5p hsa-miR-548ay-5p hsa-miR-548b-5p hsa-miR-548c-5p hsa-miR-548d-5p hsa-miR-548h-5p hsa-miR-548i hsa-miR-548j-5p hsa-miR-548o-5p hsa-miR-548w hsa-miR-548y hsa-miR-559 hsa-miR-655-3p	1 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 1	tcTGTATTActtt tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tctgtaTTACTTT tcTGTATTActtt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N N N N N N	-0.049 -0.096 -0.058 -0.058 -0.058 -0.077 -0.058 -0.077 -0.058 -0.058 -0.058 -0.058 -0.058 -0.058 -0.058 -0.058 -0.077 -0.058 -0.058 -0.058 -0.068 -0.058

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