SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001160111
Gene Symbol: NOS3
Description: Homo sapiens nitric oxide synthase 3 (endothelial cell) (NOS3), transcript variant 1, mRNA.
Gene Location: chr7(+):150690891-150701023
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003323G>A COSN15316983 CPCG0103-P6 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003401T>C COSN4921478 CPCG0103-P3 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2054 ctgcgATTACAGacgtgag
 0 CUGUAAUA m7a Created NA NA 5.680000
hsa-miR-3607-3p ctgcgaTTACAGacgtgag
 0 ACUGUAAA m6b Created no TS 0.010000 -1.130000
hsa-miR-3686 ctgcgaTTACAGAcgtgag
 0 AUCUGUAA m7b Created no TS -0.034000 -0.140000
hsa-miR-4796-5p ctgcgatTATAGACgtgag
 2
 UGUCUAUA m7b Disrupted -0.344000 -0.194000 2.330000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003404A>G ICGC_7E3F94CC-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4796-5p cgatTATAGACgtgagcca
 0 UGUCUAUA m7b Disrupted -0.344 -0.194 2.14

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003667T>A COSN2210182 RK061_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-5p ctgtctCCCTGCCAgaagt
 0 UGGCAGGG m8a Disrupted -0.440000 no TS 5.820000
hsa-miR-149-5p ctgtctcccAGCCAGAagt
 0 UCUGGCUC m7a (m6b->m7a) no TS -0.108000 -5.500000
hsa-miR-3064-5p ctgtctccCAGCCAGAagt
 0 UCUGGCUG m8a Created no TS -0.272000 -8.470000
hsa-miR-30c-1-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created -0.096000 -0.188000 -0.510000
hsa-miR-30c-2-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created -0.100000 -0.202000 -3.910000
hsa-miR-3128 ctgtctcccTGCCAGAagt
 0 UCUGGCAA m7a (m7a->m6b) -0.122000 no TS 2.250000
hsa-miR-3192 ctgtCTCCCAGccagaagt
 0 UCUGGGAG m7b Created no TS -0.146000 No effect
hsa-miR-3652 ctgtctcCCAGCCagaagt
 0 CGGCUGGA m6b Created no TS -0.140000 -7.140000
hsa-miR-4270 ctgtCTCCCTGccagaagt
 0 UCAGGGAG m7b Disrupted -0.184000 no TS 19.590000
hsa-miR-4430 ctgtctcCCAGCCagaagt
 0 AGGCUGGA m6b Created no TS -0.137000 -6.330000
hsa-miR-4441 ctgtCTCCCTGccagaagt
 0 ACAGGGAG m7b Disrupted -0.156000 no TS 5.760000
hsa-miR-4505 ctgtctCCCAGCCagaagt
 0 AGGCUGGG m7b Created no TS -0.418000 -6.980000
hsa-miR-4720-5p ctgtctcccTGCCAGaagt
 0 CCUGGCAU m6b Disrupted -0.120000 no TS 4.420000
hsa-miR-4736 ctgtctcCCTGCCagaagt
 0 AGGCAGGU m6b Disrupted -0.320000 -0.158000 2.620000
hsa-miR-4763-3p ctgtctCCCTGCCagaagt
 0 AGGCAGGG m7b Disrupted -0.419000 no TS 7.520000
hsa-miR-4794 ctgtctcccAGCCAGAagt
 0 UCUGGCUA m7a (m6b->m7a) no TS -0.124000 -11.770000
hsa-miR-4799-3p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.123000 no TS 4.900000
hsa-miR-5588-5p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.130000 no TS 9.900000
hsa-miR-5589-5p ctgtctCCCAGCCagaagt
 0 GGCUGGGU m7a Created NA NA -0.340000
hsa-miR-664-5p ctgtctcccAGCCAGaagt
 0 ACUGGCUA m6b Created no TS -0.114000 -17.170000
hsa-miR-1207-5p ctgtctCCCTGCCAgaagt
 0 UGGCAGGG m8a Disrupted -0.440000 no TS 5.820000
hsa-miR-149-5p ctgtctcccAGCCAGAagt
 0 UCUGGCUC m7a (m6b->m7a) no TS -0.108000 -5.500000
hsa-miR-3064-5p ctgtctccCAGCCAGAagt
 0 UCUGGCUG m8a Created no TS -0.272000 -8.470000
hsa-miR-30c-1-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created -0.096000 -0.188000 -0.510000
hsa-miR-30c-2-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created -0.100000 -0.202000 -3.910000
hsa-miR-3128 ctgtctcccTGCCAGAagt
 0 UCUGGCAA m7a (m7a->m6b) -0.122000 no TS 2.250000
hsa-miR-3192 ctgtCTCCCAGccagaagt
 0 UCUGGGAG m7b Created no TS -0.146000 No effect
hsa-miR-3652 ctgtctcCCAGCCagaagt
 0 CGGCUGGA m6b Created no TS -0.140000 -7.140000
hsa-miR-4270 ctgtCTCCCTGccagaagt
 0 UCAGGGAG m7b Disrupted -0.184000 no TS 19.590000
hsa-miR-4430 ctgtctcCCAGCCagaagt
 0 AGGCUGGA m6b Created no TS -0.137000 -6.330000
hsa-miR-4441 ctgtCTCCCTGccagaagt
 0 ACAGGGAG m7b Disrupted -0.156000 no TS 5.760000
hsa-miR-4505 ctgtctCCCAGCCagaagt
 0 AGGCUGGG m7b Created no TS -0.418000 -6.980000
hsa-miR-4720-5p ctgtctcccTGCCAGaagt
 0 CCUGGCAU m6b Disrupted -0.120000 no TS 4.420000
hsa-miR-4736 ctgtctcCCTGCCagaagt
 0 AGGCAGGU m6b Disrupted -0.320000 -0.158000 2.620000
hsa-miR-4763-3p ctgtctCCCTGCCagaagt
 0 AGGCAGGG m7b Disrupted -0.419000 no TS 7.520000
hsa-miR-4794 ctgtctcccAGCCAGAagt
 0 UCUGGCUA m7a (m6b->m7a) no TS -0.124000 -11.770000
hsa-miR-4799-3p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.123000 no TS 4.900000
hsa-miR-5588-5p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.130000 no TS 9.900000
hsa-miR-5589-5p ctgtctCCCAGCCagaagt
 0 GGCUGGGU m7a Created NA NA -0.340000
hsa-miR-664-5p ctgtctcccAGCCAGaagt
 0 ACUGGCUA m6b Created no TS -0.114000 -17.170000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003679C>T COSN520300 TCGA-A6-6141-01 [large_intestine][caecum][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4504 cagaagtgtTTGTCACcac
 0 UGUGACAA m7b (m6c->m7b) no TS -0.126000 -2.510000
hsa-miR-542-3p cagaagtgtCTGTCACcac
 0 UGUGACAG m7b (m7b->m6c) -0.143000 no TS 0.680000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003714G>T COSN8515975 4537_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-143-5p ctctagaACTGCACCtaga
 2
 GGUGCAGU m8a Created -0.111000 -0.283000 -0.290000
hsa-miR-3168 ctcTAGAACTgcacctaga
 0 GAGUUCUA m7b (m6b->m7b) no TS -0.049000 -4.860000
hsa-miR-4277 ctctAGAACTGCacctaga
 0 GCAGUUCU m8a Created no TS -0.121000 -7.670000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003897G>A COSN6594734 ICGC_MB82 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-1-3p ttccaggtcAGGGCTatta
 0 AAGCCCUU m6b Created no TS -0.228000 0.150000
hsa-miR-129-2-3p ttccaggtcAGGGCTatta
 0 AAGCCCUU m6b Created no TS -0.228000 0.150000
hsa-miR-3661 ttCCAGGTCAgggctatta
 2
 UGACCUGG m8a (m7a->m8a) -0.242000 -0.469000 -0.410000
hsa-miR-4323 ttccaggtcGGGGCTatta
 2
 CAGCCCCA m6b Disrupted -0.246000 no TS 8.030000
hsa-miR-4687-5p ttccaggtcAGGGCTatta
 0 CAGCCCUC m6b Created no TS -0.217000 -7.970000
hsa-miR-4732-3p ttccagGTCAGGGCtatta
 0 GCCCUGAC m8a Created no TS -0.232000 -0.510000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
151003405 rs187652305 C C hsa-miR-4796-5p
0 TATAGACgtgagc
 Disrupted
N
 -0.15

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