SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001160110
Gene Symbol: NOS3
Description: Homo sapiens nitric oxide synthase 3 (endothelial cell) (NOS3), transcript variant 1, mRNA.
Gene Location: chr7(+):150690891-150701023
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003667T>A COSN2210182 RK061_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-5p ctgtctCCCTGCCAgaagt
 0 UGGCAGGG m8a Disrupted -0.441000 no TS 5.820000
hsa-miR-149-5p ctgtctcccAGCCAGAagt
 0 UCUGGCUC m7a (m6b->m7a) no TS -0.108000 -5.500000
hsa-miR-3064-5p ctgtctccCAGCCAGAagt
 0 UCUGGCUG m8a Created no TS -0.272000 -8.470000
hsa-miR-30c-1-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created no TS -0.093000 -1.740000
hsa-miR-30c-2-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created no TS -0.103000 -9.860000
hsa-miR-3128 ctgtctcccTGCCAGAagt
 0 UCUGGCAA m7a (m7a->m6b) -0.122000 no TS 2.250000
hsa-miR-3192 ctgtCTCCCAGccagaagt
 0 UCUGGGAG m7b Created no TS -0.147000 0.090000
hsa-miR-3652 ctgtctcCCAGCCagaagt
 0 CGGCUGGA m6b Created no TS -0.140000 -7.110000
hsa-miR-4270 ctgtCTCCCTGccagaagt
 0 UCAGGGAG m7b Disrupted -0.185000 no TS 23.130000
hsa-miR-4430 ctgtctcCCAGCCagaagt
 0 AGGCUGGA m6b Created no TS -0.137000 -5.710000
hsa-miR-4441 ctgtCTCCCTGccagaagt
 0 ACAGGGAG m7b Disrupted -0.157000 no TS 5.760000
hsa-miR-4505 ctgtctCCCAGCCagaagt
 0 AGGCUGGG m7b Created no TS -0.419000 -6.980000
hsa-miR-4720-5p ctgtctcccTGCCAGaagt
 0 CCUGGCAU m6b Disrupted -0.120000 no TS 4.420000
hsa-miR-4736 ctgtctcCCTGCCagaagt
 0 AGGCAGGU m6b Disrupted -0.162000 no TS 14.010000
hsa-miR-4763-3p ctgtctCCCTGCCagaagt
 0 AGGCAGGG m7b Disrupted -0.420000 no TS 8.760000
hsa-miR-4794 ctgtctcccAGCCAGAagt
 0 UCUGGCUA m7a (m6b->m7a) no TS -0.124000 -11.770000
hsa-miR-4799-3p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.123000 no TS 4.900000
hsa-miR-5588-5p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.130000 no TS 9.900000
hsa-miR-5589-5p ctgtctCCCAGCCagaagt
 0 GGCUGGGU m7a Created NA NA -0.340000
hsa-miR-664-5p ctgtctcccAGCCAGaagt
 0 ACUGGCUA m6b Created no TS -0.114000 -17.170000
hsa-miR-1207-5p ctgtctCCCTGCCAgaagt
 0 UGGCAGGG m8a Disrupted -0.441000 no TS 5.820000
hsa-miR-149-5p ctgtctcccAGCCAGAagt
 0 UCUGGCUC m7a (m6b->m7a) no TS -0.108000 -5.500000
hsa-miR-3064-5p ctgtctccCAGCCAGAagt
 0 UCUGGCUG m8a Created no TS -0.272000 -8.470000
hsa-miR-30c-1-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created no TS -0.093000 -1.740000
hsa-miR-30c-2-3p ctgTCTCCCAGccagaagt
 0 CUGGGAGA m8a Created no TS -0.103000 -9.860000
hsa-miR-3128 ctgtctcccTGCCAGAagt
 0 UCUGGCAA m7a (m7a->m6b) -0.122000 no TS 2.250000
hsa-miR-3192 ctgtCTCCCAGccagaagt
 0 UCUGGGAG m7b Created no TS -0.147000 0.090000
hsa-miR-3652 ctgtctcCCAGCCagaagt
 0 CGGCUGGA m6b Created no TS -0.140000 -7.110000
hsa-miR-4270 ctgtCTCCCTGccagaagt
 0 UCAGGGAG m7b Disrupted -0.185000 no TS 23.130000
hsa-miR-4430 ctgtctcCCAGCCagaagt
 0 AGGCUGGA m6b Created no TS -0.137000 -5.710000
hsa-miR-4441 ctgtCTCCCTGccagaagt
 0 ACAGGGAG m7b Disrupted -0.157000 no TS 5.760000
hsa-miR-4505 ctgtctCCCAGCCagaagt
 0 AGGCUGGG m7b Created no TS -0.419000 -6.980000
hsa-miR-4720-5p ctgtctcccTGCCAGaagt
 0 CCUGGCAU m6b Disrupted -0.120000 no TS 4.420000
hsa-miR-4736 ctgtctcCCTGCCagaagt
 0 AGGCAGGU m6b Disrupted -0.162000 no TS 14.010000
hsa-miR-4763-3p ctgtctCCCTGCCagaagt
 0 AGGCAGGG m7b Disrupted -0.420000 no TS 8.760000
hsa-miR-4794 ctgtctcccAGCCAGAagt
 0 UCUGGCUA m7a (m6b->m7a) no TS -0.124000 -11.770000
hsa-miR-4799-3p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.123000 no TS 4.900000
hsa-miR-5588-5p ctgtctcccTGCCAGaagt
 0 ACUGGCAU m6b Disrupted -0.130000 no TS 9.900000
hsa-miR-5589-5p ctgtctCCCAGCCagaagt
 0 GGCUGGGU m7a Created NA NA -0.340000
hsa-miR-664-5p ctgtctcccAGCCAGaagt
 0 ACUGGCUA m6b Created no TS -0.114000 -17.170000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003679C>T COSN520300 TCGA-A6-6141-01 [large_intestine][caecum][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4504 cagaagtgtTTGTCACcac
 0 UGUGACAA m7b (m6c->m7b) no TS -0.126000 -2.510000
hsa-miR-542-3p cagaagtgtCTGTCACcac
 0 UGUGACAG m7b (m7b->m6c) -0.143000 no TS 0.680000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003714G>T COSN8515975 4537_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-143-5p ctctagaACTGCACCtaga
 2
 GGUGCAGU m8a Created 0.000000 0.000000 -2.170000
hsa-miR-3168 ctcTAGAACTgcacctaga
 0 GAGUUCUA m7b (m6b->m7b) no TS -0.049000 -4.860000
hsa-miR-4277 ctctAGAACTGCacctaga
 0 GCAGUUCU m8a Created no TS -0.121000 -7.670000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.151003897G>A COSN6594734 ICGC_MB82 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-1-3p ttccaggtcAGGGCTatta
 0 AAGCCCUU m6b Created no TS -0.228000 0.150000
hsa-miR-129-2-3p ttccaggtcAGGGCTatta
 0 AAGCCCUU m6b Created no TS -0.228000 0.150000
hsa-miR-3661 ttCCAGGTCAgggctatta
 2
 UGACCUGG m8a (m7a->m8a) -0.242000 -0.469000 -0.410000
hsa-miR-4323 ttccaggtcGGGGCTatta
 2
 CAGCCCCA m6b Disrupted -0.246000 no TS 10.220000
hsa-miR-4687-5p ttccaggtcAGGGCTatta
 0 CAGCCCUC m6b Created no TS -0.217000 -7.970000
hsa-miR-4732-3p ttccagGTCAGGGCtatta
 0 GCCCUGAC m8a Created no TS -0.232000 -0.510000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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