SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_003317
Gene Symbol: NKX2-1
Description: Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.
Gene Location: chr14(-):36985603-36988903
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr14:g.36516686T>C COSN8588601 J10_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-452-5p ccgcgaAAACAGTTtgttt
 0 AACUGUUU m8a Created no TS -0.099000 -0.290000
hsa-miR-4676-3p ccgcgaAAACAGTttgttt
 0 CACUGUUU m7b Created no TS -0.071000 -0.280000
hsa-miR-548g-3p ccgcgaaaACAGTTTgttt
 0 AAAACUGU m7b Created no TS -0.072000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.36516862G>T COSN1646236 RK042_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5580-5p actctGCCAGCAaagagga
 11
 UGCUGGCU m7a Disrupted -0.150000 no TS -0.320000
hsa-miR-5580-5p actctGCCAGCAaagagga
 11
 UGCUGGCU m7a Disrupted -0.150000 no TS -0.320000
hsa-miR-5580-5p actctGCCAGCAaagagga
 11
 UGCUGGCU m7a Disrupted -0.150000 no TS -0.320000
hsa-miR-5580-5p actctGCCAGCAaagagga
 0 UGCUGGCU m7a Disrupted -0.15 no TS -0.32

Mutation Mutation ID Sample Name Cancer Type
chr14:g.36517080G>T COSN15206490 SM-4AX84 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548ac aaatttgtgGGTTTTTttt
 19
 CAAAAACC m7b (m7b->m6b) -0.092000 0.033000 1.710000
hsa-miR-548as-3p aaatttgtGGGTTTTtttt
 0 UAAAACCC m7b Disrupted -0.331000 -0.092000 3.710000
hsa-miR-548d-3p aaatttgtgGGTTTTTttt
 19
 CAAAAACC m7b (m7b->m6b) -0.083000 0.033000 -2.230000
hsa-miR-548h-3p aaatttgtgGGTTTTTttt
 19
 CAAAAACC m7b (m7b->m6b) -0.083000 0.033000 -2.490000
hsa-miR-548z aaatttgtgGGTTTTTttt
 19
 CAAAAACC m7b (m7b->m6b) -0.083000 0.033000 -2.490000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.36517158G>A COSN5207695 SS6003133 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4799-5p cctggccgcATTTAGAcca
 0 AUCUAAAU m7b (m6b->m7b) no TS 0.041000 -1.180000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.36517190C>A COSN1167302 HCC6T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-432-5p gctgCTCCAAGcgcttcga
 0 UCUUGGAG m7b Created no TS -0.087000 -12.520000
hsa-miR-518e-3p gctgctccaAGCGCTTcga
 0 AAAGCGCU m7b (m6b->m7b) no TS -0.266000 -1.290000
hsa-miR-432-5p gctgCTCCAAGcgcttcga
 0 UCUUGGAG m7b Created no TS -0.087000 -12.520000
hsa-miR-518e-3p gctgctccaAGCGCTTcga
 0 AAAGCGCU m7b (m6b->m7b) no TS -0.266000 -1.290000
hsa-miR-432-5p gctgCTCCAAGcgcttcga
 0 UCUUGGAG m7b Created no TS -0.087000 -12.520000
hsa-miR-518e-3p gctgctccaAGCGCTTcga
 0 AAAGCGCU m7b (m6b->m7b) no TS -0.266000 -1.290000
hsa-miR-432-5p gctgCTCCAAGcgcttcga
 0 UCUUGGAG m7b Created no TS -0.087 -12.52
hsa-miR-518e-3p gctgctccaAGCGCTTcga
 0 AAAGCGCU m7b (m6b->m7b) no TS -0.266 -1.29

Mutation Mutation ID Sample Name Cancer Type
chr14:g.36517208C>- cosmic_v64_1767225 NA [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1193 cacagaccACCATCCaccg
 0 GGGAUGGU m7b Disrupted -0.282000 no TS 15.750000
hsa-miR-323a-5p cacaGACCACCatccaccg
 0 AGGUGGUC m7b Disrupted -0.460000 no TS 13.530000
hsa-miR-3691-5p cacagaccaCATCCACcg
 0 AGUGGAUG m7b (m6b->m7b) -0.090000 -0.123000 0.040000
hsa-miR-432-3p cacagaccaCCATCCAccg
 0 CUGGAUGG m7b (m7b->m6b) -0.242000 -0.111000 1.830000
hsa-miR-4764-5p cacagacCACATCCAccg
 0 UGGAUGUG m8a Created no TS -0.270000 -9.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
36517183 rs12896888 C C hsa-miR-7706
10
 GCGCTTCgacttt
 Disrupted
N
 -0.253
A hsa-miR-518e-3p
10
 GCGCTTAgacttt
 Created
N
 -0.232

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