SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_153355 |
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Gene Symbol: | NKAIN2 |
Description: | Homo sapiens Na+/K+ transporting ATPase interacting 2 (NKAIN2), transcript variant 1, mRNA. |
Gene Location: | chr6(+):124125068-125146786 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr6:g.124823468C>T | COSN1324451 | HCC77T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1268a |
tgcaggaCACGCCCatctt |
5 |
CGGGCGUG | m7b | Disrupted | -0.548000 | no TS |
1.140000 |
|
hsa-miR-1268b |
tgcaggaCACGCCCatctt |
5 |
CGGGCGUG | m7b | Disrupted | -0.548000 | no TS |
0.860000 |
|
hsa-miR-3945 |
tgcaggacATGCCCatctt |
2 |
AGGGCAUA | m6b | Created | -0.143000 | -0.316000 |
-0.720000 |
|
hsa-miR-4253 |
tgcaggaCATGCCCatctt |
2 |
AGGGCAUG | m7b | Created | -0.133000 | -0.543000 |
-3.800000 |
|
hsa-miR-1268a |
tgcaggaCACGCCCatctt |
5 |
CGGGCGUG | m7b | Disrupted | -0.548 | no TS |
1.14 |
|
hsa-miR-1268b |
tgcaggaCACGCCCatctt |
5 |
CGGGCGUG | m7b | Disrupted | -0.548 | no TS |
0.86 |
|
hsa-miR-3945 |
tgcaggacATGCCCatctt |
0 | AGGGCAUA | m6b | Created | -0.143 | -0.316 |
-0.72 |
|
hsa-miR-4253 |
tgcaggaCATGCCCatctt |
0 | AGGGCAUG | m7b | Created | -0.133 | -0.543 |
-3.8 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr6:g.124824487A>G | COSN14796462 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-421 |
tgtgCTGTTGAcgtagttg |
0 | AUCAACAG | m7b | Created | no TS | 0.058000 |
-1.170000 |
|
hsa-miR-4709-5p |
tgtgCTGTTGacgtagttg |
0 | ACAACAGU | m6b | Created | no TS | 0.028000 |
-2.500000 |
|
hsa-miR-505-3p |
tgtgcTGTTGACGtagttg |
0 | CGUCAACA | m8a | Created | no TS | -0.001000 |
-0.070000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr6:g.124824990T>C | COSN5083184 | HX31T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr6:g.124825288A>C | COSN8793250 | SS6003317 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-424-3p |
ttacagccACGTTTTcacc |
0 | CAAAACGU | m7b | Created | no TS | -0.064000 |
-0.780000 |
|
hsa-miR-548ad |
ttacagccaCGTTTTCacc |
0 | GAAAACGA | m7a | (m6b->m7a) | NA | NA | No effect | |
hsa-miR-5582-3p |
ttacagccAAGTTTTcacc |
2 |
UAAAACUU | m7b | Disrupted | 0.103000 | 0.062000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr6:g.124825532T>A | COSN9295239 | AOCS-060-1-5 | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-642a-3p |
tgatcctgATGTGTCcttt |
15 |
AGACACAU | m7b | Disrupted | -0.168000 | no TS |
0.440000 |
hsa-miR-642b-3p |
tgatcctgATGTGTCcttt |
15 |
AGACACAU | m7b | Disrupted | -0.168000 | no TS |
3.670000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
124823473 | rs149533860 | A | A |
hsa-miR-1268a hsa-miR-1268b hsa-miR-4426 hsa-miR-4647 hsa-miR-4662b hsa-miR-585-3p |
5 5 5 5 5 5 |
ACGCCCAtcttgg ACGCCCAtcttgg acgcCCATCTTgg acgcCCATCTTgg acgcCCATCTTgg ACGCCCAtcttgg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.248 -0.248 -0.05 -0.069 -0.05 -0.27 |
C |
hsa-miR-3184-5p hsa-miR-423-5p |
4 4 |
acGCCCCTCttgg acGCCCCTCttgg |
Created Created |
N N |
-0.238 -0.238 |
|||
124824487 | rs17774884 | A | |||||||
G |
hsa-miR-421 hsa-miR-4709-5p hsa-miR-505-3p hsa-miR-598-3p |
11 11 9 10 |
gCTGTTGAcgtag gCTGTTGAcgtag gcTGTTGACgtag gctgtTGACGTAg |
Created Created Created Created |
N N N N |
0.058 0.028 -0.001 -0.076 |