SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_198400
Gene Symbol: NEDD4
Description: Homo sapiens neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1, mRNA.
Gene Location: chr15(-):56119121-56209329
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr15:g.55827627A>C COSN9626676 C0076T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-584-3p attttGGAACTGtcctcat
 3
 UCAGUUCC m7b Created 0.019000 -0.141000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55827739T>C COSN5755460 HX33T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4307 gatattAAACATataaata
 0 AAUGUUUU m6b Created no TS 0.027000 -3.290000
hsa-miR-5011-5p gatattaaATATATAaata
 1
 UAUAUAUA m7a Disrupted 0.615000 0.539000 -0.580000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55827815C>A COSN6412947 HX30T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-124-5p gcaaatTGAACACactccc
 0 CGUGUUCA m7b Created no TS -0.169000 -7.550000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55828083G>A COSN9090728 8069314 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3161 ttcaccaTTATCAaccagc
 0 CUGAUAAG m6b Created no TS 0.100000 No effect
hsa-miR-380-5p ttcaccattGTCAACCAgc
 3
 UGGUUGAC m8a (m8a->m7a) -0.178000 -0.039000 2.380000
hsa-miR-563 ttcaccattGTCAACCagc
 3
 AGGUUGAC m7b (m7b->m6b) -0.157000 -0.032000 3.890000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55828887T>C COSN8747542 AOCS-149-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4765 tttttagtATCACTCtagt
 2
 UGAGUGAU m7b Disrupted -0.153000 no TS 0.010000
hsa-miR-5586-3p tttttagtaTCACTCTagt
 2
 CAGAGUGA m7b (m7b->m6b) -0.207000 -0.072000 0.240000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55828987C>A COSN7049092 8034061 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p ctagatATTCTTTacactt
 10
 CAAAGAAU m7b Disrupted 0.068000 no TS 0.470000
hsa-miR-5692a ctagatATTATTTacactt
 7
 CAAAUAAU m7b Created 0.204000 0.354000 -0.160000
hsa-miR-5692b ctagATATTATTtacactt
 2
 AAUAAUAU m8a Created -0.024000 0.016000 -1.830000
hsa-miR-5692c ctagATATTATTtacactt
 2
 AAUAAUAU m8a Created -0.024000 0.016000 -0.540000
hsa-miR-889 ctaGATATTAtttacactt
 2
 UUAAUAUC m7b (m6c->m7b) -0.050000 -0.080000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55829272A>G COSN1680189 RK049_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-30a-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181000 -0.123000 No effect
hsa-miR-30b-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182000 -0.133000 No effect
hsa-miR-30c-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182000 -0.133000 No effect
hsa-miR-30d-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181000 -0.123000 No effect
hsa-miR-30e-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181000 -0.123000 No effect
hsa-miR-548ao-5p aaactgtTTACTTCTtcac
 5
 AGAAGUAA m8a Disrupted -0.141000 no TS 0.040000
hsa-miR-548ax aaactgtTTACTTCTtcac
 5
 AGAAGUAA m8a Disrupted -0.132000 no TS No effect
hsa-miR-30a-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181 -0.123 No effect
hsa-miR-30b-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182 -0.133 No effect
hsa-miR-30c-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182 -0.133 No effect
hsa-miR-30d-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181 -0.123 No effect
hsa-miR-30e-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181 -0.123 No effect
hsa-miR-548ao-5p aaactgtTTACTTCTtcac
 0 AGAAGUAA m8a Disrupted -0.141 no TS 0.04
hsa-miR-548ax aaactgtTTACTTCTtcac
 0 AGAAGUAA m8a Disrupted -0.132 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55829413A>G COSN8747543 AOCS-134-3-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-25-3p gagtaaacTGCAATatatt
 0 CAUUGCAC m6b Created no TS -0.098000 -0.160000
hsa-miR-363-3p gagtaaacTGCAATatatt
 0 AAUUGCAC m6b Created no TS -0.091000 -0.130000
hsa-miR-367-3p gagtaaacTGCAATatatt
 0 AAUUGCAC m6b Created no TS -0.101000 -4.170000
hsa-miR-3674 gagtaaaCTACAATatatt
 0 AUUGUAGA m7a Disrupted NA NA No effect
hsa-miR-4703-3p gagtaAACTACAatatatt
 6
 UGUAGUUG m7a Disrupted -0.100000 no TS 0.260000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55829425A>G COSN8590170 4537_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-421 tactttaCTGTTGAgtaaa
 0 AUCAACAG m7b Created no TS -0.190000 -0.430000
hsa-miR-4709-5p tactttACTGTTGagtaaa
 0 ACAACAGU m7b Created no TS -0.278000 -9.480000
hsa-miR-545-5p tacTTTACTGttgagtaaa
 2
 UCAGUAAA m7b (m6c->m7b) -0.154000 -0.276000 -0.060000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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