SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006154
Gene Symbol: NEDD4
Description: Homo sapiens neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1, mRNA.
Gene Location: chr15(-):56119121-56285835
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr15:g.55827627A>C COSN9626676 C0076T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-584-3p attttGGAACTGtcctcat
 3
 UCAGUUCC m7b Created 0.019000 -0.141000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55827739T>C COSN5755460 HX33T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4307 gatattAAACATataaata
 0 AAUGUUUU m6b Created no TS 0.027000 -3.290000
hsa-miR-5011-5p gatattaaATATATAaata
 1
 UAUAUAUA m7a Disrupted 0.615000 0.539000 -0.580000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55827815C>A COSN6412947 HX30T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-124-5p gcaaatTGAACACactccc
 0 CGUGUUCA m7b Created no TS -0.169000 -7.550000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55828083G>A COSN9090728 8069314 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3161 ttcaccaTTATCAaccagc
 0 CUGAUAAG m6b Created no TS 0.100000 No effect
hsa-miR-380-5p ttcaccattGTCAACCAgc
 3
 UGGUUGAC m8a (m8a->m7a) -0.178000 -0.039000 2.380000
hsa-miR-563 ttcaccattGTCAACCagc
 3
 AGGUUGAC m7b (m7b->m6b) -0.157000 -0.032000 3.890000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55828887T>C COSN8747542 AOCS-149-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4765 tttttagtATCACTCtagt
 2
 UGAGUGAU m7b Disrupted -0.153000 no TS 0.010000
hsa-miR-5586-3p tttttagtaTCACTCTagt
 2
 CAGAGUGA m7b (m7b->m6b) -0.207000 -0.072000 0.240000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55828987C>A COSN7049092 8034061 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p ctagatATTCTTTacactt
 10
 CAAAGAAU m7b Disrupted 0.068000 no TS 0.470000
hsa-miR-5692a ctagatATTATTTacactt
 7
 CAAAUAAU m7b Created 0.204000 0.354000 -0.160000
hsa-miR-5692b ctagATATTATTtacactt
 2
 AAUAAUAU m8a Created -0.024000 0.016000 -1.830000
hsa-miR-5692c ctagATATTATTtacactt
 2
 AAUAAUAU m8a Created -0.024000 0.016000 -0.540000
hsa-miR-889 ctaGATATTAtttacactt
 2
 UUAAUAUC m7b (m6c->m7b) -0.050000 -0.080000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55829272A>G COSN1680189 RK049_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-30a-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181000 -0.123000 No effect
hsa-miR-30b-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182000 -0.133000 No effect
hsa-miR-30c-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182000 -0.133000 No effect
hsa-miR-30d-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181000 -0.123000 No effect
hsa-miR-30e-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181000 -0.123000 No effect
hsa-miR-548ao-5p aaactgtTTACTTCTtcac
 5
 AGAAGUAA m8a Disrupted -0.141000 no TS 0.040000
hsa-miR-548ax aaactgtTTACTTCTtcac
 5
 AGAAGUAA m8a Disrupted -0.132000 no TS No effect
hsa-miR-30a-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181 -0.123 No effect
hsa-miR-30b-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182 -0.133 No effect
hsa-miR-30c-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.182 -0.133 No effect
hsa-miR-30d-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181 -0.123 No effect
hsa-miR-30e-5p aaacTGTTTACttcttcac
 0 UGUAAACA m7b Disrupted -0.181 -0.123 No effect
hsa-miR-548ao-5p aaactgtTTACTTCTtcac
 0 AGAAGUAA m8a Disrupted -0.141 no TS 0.04
hsa-miR-548ax aaactgtTTACTTCTtcac
 0 AGAAGUAA m8a Disrupted -0.132 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55829413A>G COSN8747543 AOCS-134-3-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-25-3p gagtaaacTGCAATatatt
 0 CAUUGCAC m6b Created no TS -0.098000 -0.160000
hsa-miR-363-3p gagtaaacTGCAATatatt
 0 AAUUGCAC m6b Created no TS -0.091000 -0.130000
hsa-miR-367-3p gagtaaacTGCAATatatt
 0 AAUUGCAC m6b Created no TS -0.101000 -4.170000
hsa-miR-3674 gagtaaaCTACAATatatt
 0 AUUGUAGA m7a Disrupted NA NA No effect
hsa-miR-4703-3p gagtaAACTACAatatatt
 6
 UGUAGUUG m7a Disrupted -0.100000 no TS 0.260000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.55829425A>G COSN8590170 4537_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-421 tactttaCTGTTGAgtaaa
 0 AUCAACAG m7b Created no TS -0.190000 -0.430000
hsa-miR-4709-5p tactttACTGTTGagtaaa
 0 ACAACAGU m7b Created no TS -0.278000 -9.480000
hsa-miR-545-5p tacTTTACTGttgagtaaa
 2
 UCAGUAAA m7b (m6c->m7b) -0.154000 -0.276000 -0.060000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
55827029 rs140409404 A A hsa-miR-190a-3p
hsa-miR-5011-5p
1
1
 ATATATAtatcaa
aTATATATAtcaa
 Disrupted
Disrupted
N
N
 -0.161
-0.211
G hsa-miR-5580-3p
1
 atATATGTAtcaa
 Created
N
 -0.058
55827713 rs144179817 G G hsa-miR-4643
hsa-miR-466
hsa-miR-4789-3p
hsa-miR-4789-5p
1
1
1
2
 aCATGTGTAtatc
acATGTGTAtatc
acATGTGTAtatc
acatGTGTATAtc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.195
-0.058
-0.045
-0.117
A hsa-miR-4666a-5p
hsa-miR-5011-5p
1
2
 ACATGTAtatatc
acatgTATATATc
 Created
Created
N
N
 -0.092
0.054
55829136 rs7162435 A A hsa-miR-6826-5p
3
 tatCCTATTGAcc
 Disrupted
N
 -0.213
G hsa-miR-421
hsa-miR-4709-5p
hsa-miR-505-3p
3
3
4
 tatcCTGTTGAcc
tatcCTGTTGAcc
tatccTGTTGACc
 Created
Created
Created
N
N
N
 -0.03
-0.038
-0.069

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