SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_030571
Gene Symbol:	NDFIP1
Description:	Homo sapiens Nedd4 family interacting protein 1 (NDFIP1), mRNA.
Gene Location:	chr5(+):141488323-141534008
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142152194T>C			0_10				Lung cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1246	tgcacatAATCCATatttg	19	AAUGGAUU	m7b	Disrupted	-0.257	no TS	0.01
hsa-miR-3115	tgcacataACCCATATttg	17	AUAUGGGU	m8a	Created	-0.366	-0.593	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.142153426A>G			cosmic_v64_1860011				Esophageal
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4528	tatcagtaTATAATGcaca	0	UCAUUAUA	m7b	Disrupted	0.082	0.069	0.17

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
142154280	rs10515513	A	A	hsa-miR-1262 hsa-miR-3115 hsa-miR-4701-3p hsa-miR-6736-5p	2 2 2 2	TCACCCAtaacga tcACCCATAAcga TCACCCAtaacga TCACCCAtaacga	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.254 -0.367 -0.235 -0.235
142154284	rs193279275	T
			T	hsa-miR-4528 hsa-miR-592 hsa-miR-597-5p hsa-miR-616-3p	0	ccATAATGAcaca ccataaTGACACA ccataaTGACACA ccatAATGACAca	Disrupted Disrupted Disrupted Disrupted	N N N N	0.018 -0.196 -0.126 -0.054

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