SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_181659
Gene Symbol: NCOA3
Description: Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 3, mRNA.
Gene Location: chr20(+):46130600-46285621
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr20:g.47653902G>C COSN10016884 C0030T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273g-3p tgtcCAGTGGaattggtga
 3
 ACCACUGC m6b Disrupted -0.130000 -0.022000 0.960000
hsa-miR-181a-2-3p tgtcCAGTGGaattggtga
 3
 ACCACUGA m6b Disrupted -0.146000 -0.030000 1.550000
hsa-miR-25-3p tgtccaGTGCAATtggtga
 19
 CAUUGCAC m7b Created -0.048000 -0.163000 No effect
hsa-miR-32-5p tgtccaGTGCAATtggtga
 19
 UAUUGCAC m7b Created -0.045000 -0.160000 No effect
hsa-miR-363-3p tgtccaGTGCAATTggtga
 19
 AAUUGCAC m8a Created -0.072000 -0.177000 No effect
hsa-miR-367-3p tgtccaGTGCAATTggtga
 19
 AAUUGCAC m8a Created -0.048000 -0.172000 -0.020000
hsa-miR-4436b-5p tgtccAGTGGAattggtga
 4
 GUCCACUU m6b Disrupted -0.078000 -0.001000 0.290000
hsa-miR-92a-3p tgtccaGTGCAATtggtga
 19
 UAUUGCAC m7b Created -0.051000 -0.147000 No effect
hsa-miR-92b-3p tgtccaGTGCAATtggtga
 19
 UAUUGCAC m7b Created -0.051000 -0.147000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr20:g.47654220C>T COSN5134330 PD3905a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4789-3p ctacactTATGTGTtagac
 1
 CACACAUA m7b Created 0.196000 0.098000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr20:g.47654831T>G COSN1874296 RK041_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-126-5p agtccgaAATAATagcaat
 2
 CAUUAUUA m6b Disrupted 0.213000 no TS 0.050000
hsa-miR-26a-1-3p agtccgaaAGAATAGcaat
 3
 CCUAUUCU m7b Created 0.059000 0.080000 No effect
hsa-miR-26a-2-3p agtccgaaAGAATAGcaat
 3
 CCUAUUCU m7b Created 0.059000 0.080000 No effect
hsa-miR-4795-3p agtccgaAATAATAgcaat
 2
 AUAUUAUU m7b Disrupted 0.181000 no TS No effect
hsa-miR-126-5p agtccgaAATAATagcaat
 2
 CAUUAUUA m6b Disrupted 0.213000 no TS 0.050000
hsa-miR-26a-1-3p agtccgaaAGAATAGcaat
 3
 CCUAUUCU m7b Created 0.059000 0.080000 No effect
hsa-miR-26a-2-3p agtccgaaAGAATAGcaat
 3
 CCUAUUCU m7b Created 0.059000 0.080000 No effect
hsa-miR-4795-3p agtccgaAATAATAgcaat
 2
 AUAUUAUU m7b Disrupted 0.181000 no TS No effect
hsa-miR-126-5p agtccgaAATAATagcaat
 2
 CAUUAUUA m6b Disrupted 0.213 no TS 0.05
hsa-miR-26a-1-3p agtccgaaAGAATAGcaat
 0 CCUAUUCU m7b Created 0.059 0.08 No effect
hsa-miR-26a-2-3p agtccgaaAGAATAGcaat
 0 CCUAUUCU m7b Created 0.059 0.08 No effect
hsa-miR-4795-3p agtccgaAATAATAgcaat
 2
 AUAUUAUU m7b Disrupted 0.181 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr20:g.47654840T>G COSN1874298 RK182_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-219-2-3p taatagCAATTCatgggct
 2
 AGAAUUGU m6b Disrupted 0.062000 no TS 0.060000
hsa-miR-2964a-3p taataGCAATTCatgggct
 2
 AGAAUUGC m7b Disrupted -0.025000 no TS 2.710000
hsa-miR-302f taatAGCAATTcatgggct
 6
 UAAUUGCU m7b Disrupted 0.037000 0.024000 -0.340000
hsa-miR-219-2-3p taatagCAATTCatgggct
 2
 AGAAUUGU m6b Disrupted 0.062000 no TS 0.060000
hsa-miR-2964a-3p taataGCAATTCatgggct
 2
 AGAAUUGC m7b Disrupted -0.025000 no TS 2.710000
hsa-miR-302f taatAGCAATTcatgggct
 6
 UAAUUGCU m7b Disrupted 0.037000 0.024000 -0.340000

Mutation Mutation ID Sample Name Cancer Type
chr20:g.47655133A>C COSN1249728 HX17T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-151a-3p ccaCAGTCTAactgagcac
 2
 CUAGACUG m7b (m7b->m6b) 0.005000 no TS 0.420000
hsa-miR-3672 ccacAGTCTCActgagcac
 0 AUGAGACU m7b Created no TS 0.098000 -4.210000
hsa-miR-4276 ccacagtcTCACTGAGcac
 0 CUCAGUGA m8a Created no TS 0.063000 -0.670000
hsa-miR-4463 ccaCAGTCTCactgagcac
 2
 GAGACUGG m7a (m6a->m7a) 0.050000 no TS -0.010000
hsa-miR-5190 ccacagtcTCACTGagcac
 0 CCAGUGAC m6b Created no TS 0.057000 -0.680000
hsa-miR-873-3p ccaCAGTCTCactgagcac
 0 GGAGACUG m7b (m6b->m7b) no TS 0.019000 -0.560000
hsa-miR-935 ccacagtcTAACTGagcac
 7
 CCAGUUAC m6b Disrupted 0.184000 0.083000 No effect
hsa-miR-151a-3p ccaCAGTCTAactgagcac
 2
 CUAGACUG m7b (m7b->m6b) 0.005000 no TS 0.420000
hsa-miR-3672 ccacAGTCTCActgagcac
 0 AUGAGACU m7b Created no TS 0.098000 -4.210000
hsa-miR-4276 ccacagtcTCACTGAGcac
 0 CUCAGUGA m8a Created no TS 0.063000 -0.670000
hsa-miR-4463 ccaCAGTCTCactgagcac
 2
 GAGACUGG m7a (m6a->m7a) 0.050000 no TS -0.010000
hsa-miR-5190 ccacagtcTCACTGagcac
 0 CCAGUGAC m6b Created no TS 0.057000 -0.680000
hsa-miR-873-3p ccaCAGTCTCactgagcac
 0 GGAGACUG m7b (m6b->m7b) no TS 0.019000 -0.560000
hsa-miR-935 ccacagtcTAACTGagcac
 7
 CCAGUUAC m6b Disrupted 0.184000 0.083000 No effect
hsa-miR-151a-3p ccaCAGTCTAactgagcac
 2
 CUAGACUG m7b (m7b->m6b) 0.005 no TS 0.42
hsa-miR-3672 ccacAGTCTCActgagcac
 0 AUGAGACU m7b Created no TS 0.098 -4.21
hsa-miR-4276 ccacagtcTCACTGAGcac
 0 CUCAGUGA m8a Created no TS 0.063 -0.67
hsa-miR-4463 ccaCAGTCTCactgagcac
 2
 GAGACUGG m7a (m6a->m7a) 0.05 no TS -0.01
hsa-miR-5190 ccacagtcTCACTGagcac
 0 CCAGUGAC m6b Created no TS 0.057 -0.68
hsa-miR-873-3p ccaCAGTCTCactgagcac
 0 GGAGACUG m7b (m6b->m7b) no TS 0.019 -0.56
hsa-miR-935 ccacagtcTAACTGagcac
 0 CCAGUUAC m6b Disrupted 0.184 0.083 No effect

Mutation Mutation ID Sample Name Cancer Type
chr20:g.47655536C>T COSN4780692 tumor_4119027 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][Burkitt_lymphoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3616-3p tgagttTGCCCTCtttccc
 0 CGAGGGCA m7b Disrupted -0.158000 no TS 1.540000
hsa-miR-4311 tgagtttgcTCTCTTTCcc
 0 GAAAGAGA m8a (m7b->m8a) 0.266000 0.418000 -0.010000
hsa-miR-4470 tgaGTTTGCCctctttccc
 0 UGGCAAAC m7b (m7b->m6b) -0.106000 -0.064000 0.050000
hsa-miR-583 tgagtttgcCCTCTTTccc
 0 CAAAGAGG m7b (m7b->m6c) 0.096000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr20:g.47656365A>G COSN8000142 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
47653603 rs6094766 C C hsa-miR-1277-3p
hsa-miR-3935
16
10
 taTCTACGTgttt
TATCTACgtgttt
 Disrupted
Disrupted
N
N
 -0.274
-0.134
T hsa-miR-376c-3p
hsa-miR-4789-3p
16
10
 taTCTATGTgttt
tatcTATGTGTtt
 Created
Created
N
N
 -0.165
-0.094
47653901 rs72646209 G G hsa-miR-1273g-3p
hsa-miR-181a-2-3p
hsa-miR-4436b-5p
hsa-miR-6509-3p
3
3
4
3
 tcCAGTGGAattg
tcCAGTGGAattg
tccAGTGGAAttg
tcCAGTGGAAttg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.108
-0.116
-0.077
-0.244
A hsa-miR-1243
hsa-miR-3654
3
3
 TCCAGTAgaattg
TCCAGTAgaattg
 Created
Created
N
N
 -0.116
-0.163
47654864 rs144164627 - - hsa-miR-329-3p
hsa-miR-362-3p
hsa-miR-3941
hsa-miR-4789-3p
hsa-miR-603
0 tGTGTGTAtgtgtgt
tGTGTGTAtgtgtgt
tGTGTGTAtgtgtgt
tgtgtgTATGTGTgt
tGTGTGTAtgtgtgt
 Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
 -0.001
-0.001
-0.021
-0.003
-0.001
TG
47654864 rs6090710 - A hsa-miR-329-3p
hsa-miR-362-3p
hsa-miR-3941
hsa-miR-4789-3p
hsa-miR-603
0 GTGTGTAtgtgtg
GTGTGTAtgtgtg
GTGTGTAtgtgtg
gtgtgTATGTGTg
GTGTGTAtgtgtg
 Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
 0.04
0.04
0.019
0.135
0.044
47654865 rs34418081 - - hsa-miR-4789-3p
0 gtgtgTATGTGTgtg
 Unknown
N
 0.135
TG hsa-miR-323b-3p
0 gtgtGTATTGGtgtgtg
 Unknown
N
 0.028
47654866 rs33992969 - - hsa-miR-4789-3p
0 tgtgTATGTGTgtgt
 Unknown
N
 0.135
GT
47655399 rs72646213 A
G hsa-miR-4463
hsa-miR-4794
hsa-miR-548u
hsa-miR-664a-5p
hsa-miR-7161-5p
hsa-miR-892b
2
3
2
3
2
3
 tagCCAGTCTttc
TAGCCAGtctttc
tagccAGTCTTTc
TAGCCAGtctttc
tagccAGTCTTTc
tAGCCAGTctttc
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.03
-0.07
0.105
-0.089
0.114
-0.1
47655844 rs11547289 C C hsa-miR-504-3p
2
 GCACTCCcttttt
 Disrupted
N
 -0.141
T hsa-miR-4311
hsa-miR-4693-3p
3
2
 gcacTCTCTTTtt
gCACTCTCttttt
 Created
Created
N
N
 0.027
-0.103

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