SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_153604
Gene Symbol: MYOCD
Description: Homo sapiens myocardin (MYOCD), transcript variant 1, mRNA.
Gene Location: chr17(+):12569206-12670651
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12763658C>T COSN1081768 TCGA-AP-A051-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-33a-5p ccCAATGCACcagtgctat
 2
 GUGCAUUG m8a (m8a->m7a) -0.216000 -0.216000 No effect
hsa-miR-33b-5p ccCAATGCACcagtgctat
 2
 GUGCAUUG m8a (m8a->m7a) -0.216000 -0.216000 No effect
hsa-miR-548q cccaatGCACCAGtgctat
 2
 GCUGGUGC m7b Disrupted 0.000000 no TS No effect
hsa-miR-586 cccAATGCATcagtgctat
 6
 UAUGCAUU m7b (m6b->m7b) -0.141000 -0.282000 No effect
hsa-miR-33a-5p ccCAATGCACcagtgctat
 0 GUGCAUUG m8a (m8a->m7a) -0.216 -0.216 No effect
hsa-miR-33b-5p ccCAATGCACcagtgctat
 0 GUGCAUUG m8a (m8a->m7a) -0.216 -0.216 No effect
hsa-miR-548q cccaatGCACCAGtgctat
 2
 GCUGGUGC m7b Disrupted 0 no TS No effect
hsa-miR-586 cccAATGCATcagtgctat
 0 UAUGCAUU m7b (m6b->m7b) -0.141 -0.282 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12764410C>A COSN9655572 C0004T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3127-5p agatgagaaCCCTGAagaa
 3
 AUCAGGGC m6b Disrupted -0.079000 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12766353T>C COSN5838316 HX34T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12766644G>T COSN8831446 AOCS-122-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p gtgtcTTTTTTGatgacaa
 11
 ACAAAAAA m7b Created 0.536000 0.673000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12766749T>C 11_4432 2542 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-5p tgtgtAGTTCTCttaagac
 8
 UGAGAACU m7b Created no TS -0.143 No effect
hsa-miR-146b-5p tgtgtAGTTCTCttaagac
 8
 UGAGAACU m7b Created no TS -0.124 No effect
hsa-miR-3925-5p tgtgtaGTTCTCTTaagac
 6
 AAGAGAAC m8a Created no TS -0.124 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.12766982G>T COSN1193091 BN50T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1238 aggGAGGAAGaagagggag
 4
 CUUCCUCG m7a (m7a->m6a) -0.285000 -0.289000 0.240000
hsa-miR-4778-3p agggagGAAGAAGAgggag
 0 UCUUCUUC m8a Disrupted -0.946000 -0.905000 1.180000
hsa-miR-877-3p agggaggaaGAAGAGGgag
 1
 UCCUCUUC m7b (m7b->m6c) -0.154000 no TS 1.140000
hsa-miR-1238 aggGAGGAAGaagagggag
 0 CUUCCUCG m7a (m7a->m6a) -0.285 -0.289 0.24
hsa-miR-4778-3p agggagGAAGAAGAgggag
 1
 UCUUCUUC m8a Disrupted -0.946 -0.905 0.58
hsa-miR-877-3p agggaggaaGAAGAGGgag
 0 UCCUCUUC m7b (m7b->m6c) -0.154 no TS 1.14


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12767026G>C COSN6650395 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr17:g.12767068G>T COSN1193092 BN42T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1236 gaaaGAAGAGaggaaagaa
 0 CCUCUUCC m6b Disrupted -0.405000 -0.350000 1.970000
hsa-miR-1238 gaaagaagaGAGGAAagaa
 4
 CUUCCUCG m6b Disrupted -0.285000 -0.194000 No effect
hsa-miR-141-5p gaaaGAAGATaggaaagaa
 0 CAUCUUCC m6b Created -0.167000 -0.203000 -0.010000
hsa-miR-202-5p gaaagaagATAGGAAagaa
 0 UUCCUAUG m7a Created no TS -0.098000 -0.090000
hsa-miR-3183 gaaagaAGAGAGGaaagaa
 2
 GCCUCUCU m7b Disrupted -0.445000 -0.102000 0.010000
hsa-miR-337-3p gaaagaagATAGGAaagaa
 0 CUCCUAUA m6b Created no TS -0.102000 -3.740000
hsa-miR-384 gaaagaagaTAGGAAagaa
 0 AUUCCUAG m6b Created no TS -0.051000 -1.130000
hsa-miR-4723-3p gaaagaAGAGAGGaaagaa
 2
 CCCUCUCU m7b Disrupted -0.533000 -0.158000 0.020000
hsa-miR-1236 gaaaGAAGAGaggaaagaa
 0 CCUCUUCC m6b Disrupted -0.405 -0.35 1.97
hsa-miR-1238 gaaagaagaGAGGAAagaa
 0 CUUCCUCG m6b Disrupted -0.285 -0.194 No effect
hsa-miR-141-5p gaaaGAAGATaggaaagaa
 0 CAUCUUCC m6b Created -0.167 -0.203 -0.01
hsa-miR-202-5p gaaagaagATAGGAAagaa
 0 UUCCUAUG m7a Created no TS -0.098 -0.09
hsa-miR-3183 gaaagaAGAGAGGaaagaa
 2
 GCCUCUCU m7b Disrupted -0.445 -0.102 0.01
hsa-miR-337-3p gaaagaagATAGGAaagaa
 0 CUCCUAUA m6b Created no TS -0.102 -3.74
hsa-miR-384 gaaagaagaTAGGAAagaa
 0 AUUCCUAG m6b Created no TS -0.051 -1.13
hsa-miR-4723-3p gaaagaAGAGAGGaaagaa
 2
 CCCUCUCU m7b Disrupted -0.533 -0.158 0.02

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
12763659 rs113878045 C C hsa-miR-548q
2
 atGCACCAGtgct
 Disrupted
N
 No Change
G hsa-miR-4536-3p
hsa-miR-4636
hsa-miR-517a-3p
hsa-miR-517b-3p
hsa-miR-517c-3p
2
1
2
2
2
 ATGCACGAgtgct
atgCACGAGTgct
aTGCACGAgtgct
aTGCACGAgtgct
aTGCACGAgtgct
 Created
Created
Created
Created
Created
N
N
N
N
N
 No Change
No Change
No Change
No Change
No Change
12763674 rs183584861 C C hsa-miR-6843-3p
hsa-miR-6848-3p
6
6
 ggaAGACCAAtgg
ggaAGACCAAtgg
 Disrupted
Disrupted
N
N
 -0.12
-0.117
T hsa-miR-141-5p
hsa-miR-7641
8
6
 GGAAGATcaatgg
ggaAGATCAAtgg
 Created
Created
N
N
 -0.186
-0.094
12764437 rs180850229 C C hsa-miR-4787-5p
hsa-miR-625-5p
hsa-miR-6727-5p
2
2
2
 ttCCCCCGAagga
TTCCCCCgaagga
ttcCCCCGAAgga
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.203
-0.104
-0.18
T hsa-miR-205-5p
hsa-miR-3127-5p
hsa-miR-6783-5p
hsa-miR-6798-5p
2
2
2
2
 ttccccTGAAGGA
ttcCCCTGAAgga
TTCCCCTgaagga
ttCCCCTGAagga
 Created
Created
Created
Created
N
N
N
N
 0.002
-0.075
-0.085
-0.108
12766401 rs191139944 A A hsa-miR-29b-2-5p
hsa-miR-33a-5p
hsa-miR-33b-5p
hsa-miR-3680-3p
hsa-miR-5087
3
2
2
2
3
 taatgcAAACCAA
tAATGCAAaccaa
tAATGCAAaccaa
taATGCAAAccaa
taatgCAAACCAa
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 0.025
0.018
0.018
-0.002
-0.042
G hsa-miR-218-1-3p
hsa-miR-659-3p
3
3
 taatgcGAACCAA
taatgcGAACCAA
 Created
Created
N
N
 -0.045
-0.03

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