SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001185118
Gene Symbol:	MYNN
Description:	Homo sapiens myoneurin (MYNN), transcript variant 2, mRNA.
Gene Location:	chr3(+):169490852-169507504
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.169787975T>C			COSN9763618		C0074T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3148	cttttTTTTTCCccccaca	1	UGGAAAAA	m7b	Disrupted	0.146000	0.155000	0.010000
hsa-miR-4525	cttttttttTCCCCCCaca	0	GGGGGGAU	m7a	(m7a->m6b)	NA	NA	-0.180000
hsa-miR-4668-5p	ctttttTTTTCCCcccaca	1	AGGGAAAA	m7b	Disrupted	0.031000	0.054000	0.410000
hsa-miR-625-5p	ctttttttTTCCCCCcaca	1	AGGGGGAA	m7b	Disrupted	-0.101000	-0.072000	-0.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.169788899T>C			COSN6743119		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-488-5p	atttagttgTATCTGGtat	5	CCCAGAUA	m7b	(m7b->m6c)	-0.139000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.169789582A>G			ICGC_D911FDB8-2A78-11E2-B303-24FD496BB9B8		CPCG_0103_Pr_P_P6		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273d	gcctccTGGGTTCaagcaa	0	GAACCCAU	m7a	Created	-0.052	-0.052	-12.1

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.169789622T>G			ICGC_9A8BA328-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5588-3p	agtagcTGGGACTacaggt	0	AAGUCCCA	m7b	Created	-0.07	-0.385	No effect
hsa-miR-624-5p	agtagcTGGTACTAcaggt	1	UAGUACCA	m8a	Disrupted	-0.29	no TS	0.1
hsa-miR-634	agtaGCTGGTactacaggt	1	AACCAGCA	m6b	Disrupted	-0.145	no TS	-0.32

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
169788901	rs145847218	T	T	hsa-miR-488-5p	7	gttgTATCTGGta	Disrupted	N	-0.139
			C	hsa-miR-1911-3p hsa-miR-6753-5p	9 9	gttgtaCCTGGTA gttgtaCCTGGTA	Created Created	N N	-0.128 -0.125

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