SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_138768
Gene Symbol:	MYEOV
Description:	Homo sapiens myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas) (MYEOV), mRNA.
Gene Location:	chr11(+):69061621-69064754
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.69296480T>C			COSN4699172		PD4103a		[breast][NS][carcinoma][ductal_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1258	accccccaCCTAACagatg	0	AGUUAGGA	m6b	Created	no TS	-0.104000	-0.560000
hsa-miR-4447	acCCCCCACCtaacagatg	2	GGUGGGGG	m8a	(m7a->m8a)	-0.295000	-0.268000	-0.270000
hsa-miR-4472	acCCCCCACCtaacagatg	2	GGUGGGGG	m8a	(m7a->m8a)	-0.305000	-0.278000	-0.470000
hsa-miR-92a-2-5p	accCCCCACCtaacagatg	0	GGGUGGGG	m7b	(m6b->m7b)	no TS	-0.262000	-1.640000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.69296936T>G			COSN8688982		AOCS-155-3-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-128	cagaCACTGTGctgggtgt	2	UCACAGUG	m7b	Disrupted	-0.091000	no TS	0.010000
hsa-miR-199a-5p	cagACACTGGGctgggtgt	0	CCCAGUGU	m8a	Created	no TS	-0.064000	-3.380000
hsa-miR-199b-5p	cagACACTGGGctgggtgt	0	CCCAGUGU	m8a	Created	no TS	-0.064000	0.750000
hsa-miR-3681-3p	cagaCACTGTGctgggtgt	2	ACACAGUG	m7b	Disrupted	-0.091000	no TS	No effect
hsa-miR-4690-3p	cagacacTGGGCTGggtgt	0	GCAGCCCA	m7b	Created	no TS	-0.125000	-7.350000
hsa-miR-5685	cagacacTGGGCTGggtgt	0	ACAGCCCA	m7b	Created	no TS	-0.125000	-7.340000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
69296603	rs183245147	C	C	hsa-miR-3162-5p hsa-miR-5584-5p hsa-miR-6077 hsa-miR-6750-5p hsa-miR-6822-5p	1 1 2 1 1	cctctTCCCTAAc cctcTTCCCTAac cCTCTTCCctaac cctcTTCCCTAac cctcTTCCCTAac	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.137 -0.119 -0.117 -0.128 -0.128
			T	hsa-miR-1258 hsa-miR-4496 hsa-miR-583	1 1 2	cctcttTCCTAAC cctcTTTCCTAac CCTCTTTcctaac	Created Created Created	N N N	-0.219 -0.042 -0.065

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