SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002467
Gene Symbol:	MYC
Description:	Homo sapiens v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), mRNA.
Gene Location:	chr8(+):128748314-128753680
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741008A>G			COSN15315257		SNUH_G76_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741026A>C			COSN15560881		AOCS-064-1-6		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3607-5p	cttgttTCACATGCatgat	0	GCAUGUGA	m8a	Created	no TS	-0.217000	-1.290000
hsa-miR-4666b	cttgtttcACATGCAtgat	0	UUGCAUGU	m7b	Created	no TS	-0.184000	-3.860000
hsa-miR-586	cttgtttcaAATGCATgat	11	UAUGCAUU	m7b	(m7b->m6c)	-0.142000	no TS	0.040000
hsa-miR-3607-5p	cttgttTCACATGCatgat	0	GCAUGUGA	m8a	Created	no TS	-0.217000	-1.290000
hsa-miR-4666b	cttgtttcACATGCAtgat	0	UUGCAUGU	m7b	Created	no TS	-0.184000	-3.860000
hsa-miR-586	cttgtttcaAATGCATgat	11	UAUGCAUU	m7b	(m7b->m6c)	-0.142000	no TS	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741064T>C			COSN5674198		RK279_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-24-3p	ttggCTGAGCCttgagact	10	UGGCUCAG	m7b	Created	-0.204000	-0.401000	-0.190000
hsa-miR-4432	ttggctGAGTCTTgagact	3	AAAGACUC	m7b	Disrupted	-0.177000	no TS	-1.890000
hsa-miR-512-5p	ttgGCTGAGTcttgagact	3	CACUCAGC	m7b	(m7b->m6b)	-0.214000	no TS	-3.220000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741083A>C			COSN9255250		C0076T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-135a-5p	gaaagatttAGCCATAatg	13	UAUGGCUU	m7a	(m7a->m6b)	-0.170000	no TS	-4.480000
hsa-miR-135b-5p	gaaagatttAGCCATAatg	13	UAUGGCUU	m7a	(m7a->m6b)	-0.170000	no TS	-2.680000
hsa-miR-652-3p	gaaagatttCGCCATaatg	0	AAUGGCGC	m6b	Created	no TS	-0.267000	-10.810000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741086C>A			COSN9597077		AOCS-080-1-9		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-135a-5p	agatttAGCCATAatgtaa	13	UAUGGCUU	m7a	Disrupted	-0.170000	no TS	-4.480000
hsa-miR-135b-5p	agatttAGCCATAatgtaa	13	UAUGGCUU	m7a	Disrupted	-0.170000	no TS	-2.680000
hsa-miR-137	agatttAGCAATAAtgtaa	0	UUAUUGCU	m8a	Created	no TS	-0.321000	0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741090A>G			COSN15505137		AOCS-170-3-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-323a-3p	ttagccaTAATGTaaactg	6	CACAUUAC	m6b	Disrupted	-0.017000	no TS	-6.620000
hsa-miR-4704-5p	ttagccaTAGTGTaaactg	0	GACACUAG	m6b	Created	no TS	-0.100000	No effect
hsa-miR-323a-3p	ttagccaTAATGTaaactg	6	CACAUUAC	m6b	Disrupted	-0.017000	no TS	-6.620000
hsa-miR-4704-5p	ttagccaTAGTGTaaactg	0	GACACUAG	m6b	Created	no TS	-0.100000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741277C>A			COSN1359443		HCC108T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4778-5p	gcagttacACAGAATTtca	1	AAUUCUGU	m8a	Disrupted	-0.133000	no TS	0.240000
hsa-miR-4778-5p	gcagttacACAGAATTtca	0	AAUUCUGU	m8a	Disrupted	-0.133	no TS	0.24

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.127741314A>C			COSN14898034		LP6005500-DNA_B03		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-374a-5p	tagTATTATAggtactata	1	UUAUAAUA	m7b	(m7b->m6b)	-0.014000	no TS	-2.110000
hsa-miR-374b-5p	tagTATTATAggtactata	1	AUAUAAUA	m7b	(m7b->m6b)	-0.014000	no TS	-1.910000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
127741004	rs200570465	A	A	hsa-miR-1178-3p hsa-miR-3934-3p	1 1	cTGAGCAAtcacc CTGAGCAatcacc	Disrupted Disrupted	N N	-0.16 -0.217
			C	hsa-miR-24-3p hsa-miR-4284	1 1	CTGAGCCAtcacc cTGAGCCAtcacc	Created Created	LT N	-0.402 -0.163
127741067	rs14607	T	T	hsa-miR-4432 hsa-miR-513c-5p hsa-miR-514b-5p	3 2 2	GAGTCTTgagact gagtCTTGAGAct gagtCTTGAGAct	Disrupted Disrupted Disrupted	N N N	-0.177 -0.13 -0.148
			C	hsa-miR-516a-5p	2	gagtCTCGAGAct	Created	N	-0.297
127741085	rs185650723	C	C	hsa-miR-135a-5p hsa-miR-135b-5p hsa-miR-8074 hsa-miR-889-5p	13 13 11 13	atttAGCCATAat atttAGCCATAat atttaGCCATAAt atttAGCCATAat	Disrupted Disrupted Disrupted Disrupted	LT N N N	-0.17 -0.17 -0.197 -0.164
			T	hsa-miR-6831-3p	12	atTTAGTCAtaat	Created	N	-0.131
127741087	rs4645970	A	A	hsa-miR-135a-5p hsa-miR-135b-5p hsa-miR-8074 hsa-miR-889-5p	13 13 11 13	ttAGCCATAatgt ttAGCCATAatgt ttaGCCATAAtgt ttAGCCATAatgt	Disrupted Disrupted Disrupted Disrupted	LT N N N	-0.17 -0.17 -0.197 -0.164
			G	hsa-miR-323a-3p	14	ttagccGTAATGT	Created	N	-0.151
127741295	rs190322311	A
			G	hsa-miR-1284 hsa-miR-4704-5p hsa-miR-4789-5p	2 1 1	cctagTGTATAGt cCTAGTGTAtagt cctaGTGTATAgt	Created Created Created	N N N	-0.152 -0.386 -0.147

Genome Browser