| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_004685 |
|---|---|
| Gene Symbol: | MTMR6 |
| Description: | Homo sapiens myotubularin related protein 6 (MTMR6), mRNA. |
| Gene Location: | chr13(-):25820340-25861704 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr13:g.25246614A>G | COSN8864280 | SNUH_G45_S1 | [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-let-7f-2-3p |
tataaaaCTGTATAGttgc |
0 | CUAUACAG | m8a | Created | no TS | -0.107000 |
-0.020000 |
|
| hsa-miR-1185-1-3p |
tataaaaCTGTATAgttgc |
0 | AUAUACAG | m7b | Created | no TS | -0.107000 |
-0.010000 |
|
| hsa-miR-1185-2-3p |
tataaaaCTGTATAgttgc |
0 | AUAUACAG | m7b | Created | no TS | -0.116000 | No effect | |
| hsa-miR-1284 |
tataaaacTGTATAGttgc |
12 |
UCUAUACA | m7b | Created | -0.001000 | -0.105000 |
-0.070000 |
|
| hsa-miR-4328 |
tatAAAACTGtatagttgc |
5 |
CCAGUUUU | m7b | (m6c->m7b) | -0.009000 | -0.148000 |
-0.010000 |
|
| hsa-miR-582-5p |
tataaAACTGTAtagttgc |
0 | UUACAGUU | m7b | Created | no TS | -0.158000 |
-0.010000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr13:g.25247267G>C | COSN7396702 | 8012199 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-181a-5p |
ttttacttTGAATGTTttt |
7 |
AACAUUCA | m8a | Disrupted | -0.070000 | no TS |
0.010000 |
|
| hsa-miR-181b-5p |
ttttacttTGAATGTTttt |
7 |
AACAUUCA | m8a | Disrupted | -0.070000 | no TS | No effect | |
| hsa-miR-181c-5p |
ttttacttTGAATGTTttt |
7 |
AACAUUCA | m8a | Disrupted | -0.070000 | no TS | No effect | |
| hsa-miR-181d |
ttttacttTGAATGTTttt |
7 |
AACAUUCA | m8a | Disrupted | -0.070000 | no TS |
0.040000 |
|
| hsa-miR-3973 |
tttTACTTTGaatgttttt |
1 |
ACAAAGUA | m7b | (m7b->m6c) | -0.318000 | -0.266000 |
0.030000 |
|
| hsa-miR-4262 |
ttttacttTGAATGTtttt |
7 |
GACAUUCA | m7b | Disrupted | -0.061000 | no TS | No effect | |
| hsa-miR-520g |
ttttACTTTGaatgttttt |
1 |
ACAAAGUG | m6b | Disrupted | -0.033000 | -0.062000 |
0.010000 |
|
| hsa-miR-520h |
ttttACTTTGaatgttttt |
1 |
ACAAAGUG | m6b | Disrupted | -0.033000 | -0.062000 |
0.010000 |
|
| hsa-miR-543 |
ttttactttGAATGTTTtt |
1 |
AAACAUUC | m8a | (m8a->m7a) | -0.054000 | -0.015000 |
0.900000 |
|
| hsa-miR-548aq-5p |
ttTTACTTTCaatgttttt |
1 |
GAAAGUAA | m8a | (m7b->m8a) | -0.078000 | -0.078000 |
-0.100000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr13:g.25248110A>G | COSN15393495 | AOCS-092-1-6 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-202-5p |
taaatATAGGAAaaaaaag |
0 | UUCCUAUG | m7a | Created | no TS | -0.044000 |
-0.030000 |
|
| hsa-miR-337-3p |
taaaTATAGGAaaaaaaag |
0 | CUCCUAUA | m7b | Created | no TS | -0.096000 |
-0.080000 |
|
| hsa-miR-3685 |
taaataTAGGAAAaaaaag |
3 |
UUUCCUAC | m7a | Created | -0.131000 | -0.163000 | No effect | |
| hsa-miR-384 |
taaataTAGGAAaaaaaag |
0 | AUUCCUAG | m6b | Created | -0.407000 | -0.430000 | No effect | |
| hsa-miR-4482-3p |
taaatATAGAAAaaaaaag |
2 |
UUUCUAUU | m7a | Disrupted | 0.040000 | no TS | No effect | |
| hsa-miR-202-5p |
taaatATAGGAAaaaaaag |
0 | UUCCUAUG | m7a | Created | no TS | -0.044000 |
-0.030000 |
|
| hsa-miR-337-3p |
taaaTATAGGAaaaaaaag |
0 | CUCCUAUA | m7b | Created | no TS | -0.096000 |
-0.080000 |
|
| hsa-miR-3685 |
taaataTAGGAAAaaaaag |
3 |
UUUCCUAC | m7a | Created | -0.131000 | -0.163000 | No effect | |
| hsa-miR-384 |
taaataTAGGAAaaaaaag |
0 | AUUCCUAG | m6b | Created | -0.407000 | -0.430000 | No effect | |
| hsa-miR-4482-3p |
taaatATAGAAAaaaaaag |
2 |
UUUCUAUU | m7a | Disrupted | 0.040000 | no TS | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr13:g.25248298A>C | COSN15247983 | LP6007420-DNA_A01 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-376c |
agtacatgTCTATGTatat |
6 |
AACAUAGA | m7b | Created | -0.060000 | -0.193000 |
-0.150000 |
|
| hsa-miR-4666a-5p |
agtACATGTATatgtatat |
16 |
AUACAUGU | m8a | Disrupted | -0.130000 | -0.007000 | No effect | |
| hsa-miR-5580-3p |
agtacatgtATATGTatat |
2 |
CACAUAUG | m6b | Disrupted | 0.037000 | no TS | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr13:g.25248995C>T | COSN1156924 | HCC73T | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-5585-3p |
atgtattTATTCAaaacac |
8 |
CUGAAUAG | m6b | Created | 0.067000 | 0.007000 | No effect | |
| hsa-miR-5585-3p |
atgtattTATTCAaaacac |
0 | CUGAAUAG | m6b | Created | 0.067 | 0.007 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr13:g.25249087A>G | COSN6620661 | CHC433T | [liver][NS][carcinoma][hepatocellular_carcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-4436b-3p |
ataataaCTGCCCTtgtga |
0 | CAGGGCAG | m7b | Created | no TS | -0.258000 | No effect |
| hsa-miR-548au-3p |
ataatAACTGCCcttgtga |
5 |
UGGCAGUU | m7b | Created | -0.179000 | -0.430000 |
-0.330000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 25246614 | rs75052956 | A | |||||||
| G |
hsa-let-7f-2-3p hsa-miR-1185-1-3p hsa-miR-1185-2-3p hsa-miR-1284 hsa-miR-4328 hsa-miR-582-5p |
4 4 4 4 4 5 |
aaaaCTGTATAgt aaaaCTGTATAgt aaaaCTGTATAgt aaaacTGTATAGt AAAACTGtatagt aaAACTGTAtagt |
Created Created Created Created Created Created |
N N N N N N |
-0.107 -0.107 -0.116 -0.104 -0.139 -0.158 |
|||
| 25248972 | rs79812219 | C | C |
hsa-let-7a-2-3p hsa-let-7g-3p hsa-miR-3177-5p hsa-miR-4280 |
6 6 6 6 |
aCTGTACActagt aCTGTACActagt acTGTACACtagt actgTACACTAgt |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.165 -0.174 -0.206 -0.116 |
| T |
hsa-let-7f-2-3p hsa-miR-1185-1-3p hsa-miR-1185-2-3p hsa-miR-3923 |
6 6 6 11 |
aCTGTATActagt aCTGTATActagt aCTGTATActagt actgtaTACTAGT |
Created Created Created Created |
N N N N |
-0.142 -0.105 -0.086 -0.21 |
|||
| 25249087 | rs4296130 | G | A |
hsa-miR-101-5p hsa-miR-6755-5p |
0 |
ATAACTAcccttg ataaCTACCCTtg |
Created Created |
N N |
-0.045 -0.284 |
| G |
hsa-miR-4436b-3p hsa-miR-4632-5p hsa-miR-548au-3p hsa-miR-6735-5p hsa-miR-6879-5p hsa-miR-7843-5p |
0 |
ataaCTGCCCTtg ataaCTGCCCTtg atAACTGCCcttg ataaCTGCCCTtg ataaCTGCCCTtg ataaCTGCCCTtg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.258 -0.258 -0.251 -0.277 -0.258 -0.333 |