| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_007351 |
|---|---|
| Gene Symbol: | MMRN1 |
| Description: | Homo sapiens multimerin 1 (MMRN1), mRNA. |
| Gene Location: | chr4(+):90816051-90875780 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr4:g.89953966A>G | COSN2049320 | RK029_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1279 |
actgaaAATATGAaaaatg |
3 |
UCAUAUUG | m7a | Disrupted | -0.103000 | -0.097000 |
0.450000 |
|
| hsa-miR-130a-5p |
actgaaAATGTGAAaaatg |
0 | UUCACAUU | m8a | Created | no TS | -0.176000 |
-0.190000 |
|
| hsa-miR-23a-3p |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.176000 |
-2.250000 |
|
| hsa-miR-23b-3p |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.176000 |
-1.810000 |
|
| hsa-miR-23c |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.197000 |
-4.730000 |
|
| hsa-miR-335-3p |
actgaaaatATGAAAAAtg |
1 |
UUUUUCAU | m8a | (m8a->m7b) | -0.307000 | -0.127000 | No effect | |
| hsa-miR-5007-3p |
actgaaaATATGAaaaatg |
3 |
AUCAUAUG | m6b | Disrupted | -0.090000 | -0.055000 |
0.700000 |
|
| hsa-miR-5096 |
actgaaaatGTGAAAaatg |
0 | GUUUCACC | m6b | Created | no TS | -0.039000 |
-0.420000 |
|
| hsa-miR-1279 |
actgaaAATATGAaaaatg |
3 |
UCAUAUUG | m7a | Disrupted | -0.103000 | -0.097000 |
0.450000 |
|
| hsa-miR-130a-5p |
actgaaAATGTGAAaaatg |
0 | UUCACAUU | m8a | Created | no TS | -0.176000 |
-0.190000 |
|
| hsa-miR-23a-3p |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.176000 |
-2.250000 |
|
| hsa-miR-23b-3p |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.176000 |
-1.810000 |
|
| hsa-miR-23c |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.197000 |
-4.730000 |
|
| hsa-miR-335-3p |
actgaaaatATGAAAAAtg |
1 |
UUUUUCAU | m8a | (m8a->m7b) | -0.307000 | -0.127000 | No effect | |
| hsa-miR-5007-3p |
actgaaaATATGAaaaatg |
3 |
AUCAUAUG | m6b | Disrupted | -0.090000 | -0.055000 |
0.700000 |
|
| hsa-miR-5096 |
actgaaaatGTGAAAaatg |
0 | GUUUCACC | m6b | Created | no TS | -0.039000 |
-0.420000 |
|
| hsa-miR-1279 |
actgaaAATATGAaaaatg |
3 |
UCAUAUUG | m7a | Disrupted | -0.103 | -0.097 |
0.45 |
|
| hsa-miR-130a-5p |
actgaaAATGTGAAaaatg |
0 | UUCACAUU | m8a | Created | no TS | -0.176 |
-0.19 |
|
| hsa-miR-23a-3p |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.176 |
-2.25 |
|
| hsa-miR-23b-3p |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.176 |
-1.81 |
|
| hsa-miR-23c |
actgaaAATGTGAaaaatg |
0 | AUCACAUU | m7b | Created | no TS | -0.197 |
-4.73 |
|
| hsa-miR-335-3p |
actgaaaatATGAAAAAtg |
0 | UUUUUCAU | m8a | (m8a->m7b) | -0.307 | -0.127 | No effect | |
| hsa-miR-5007-3p |
actgaaaATATGAaaaatg |
3 |
AUCAUAUG | m6b | Disrupted | -0.09 | -0.055 |
0.7 |
|
| hsa-miR-5096 |
actgaaaatGTGAAAaatg |
0 | GUUUCACC | m6b | Created | no TS | -0.039 |
-0.42 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr4:g.89954085C>A | COSN5579938 | RK118_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1908 |
tttaccgccCCCCGCCcca |
0 | CGGCGGGG | m7b | (m7b->m6c) | -0.222000 | no TS |
3.030000 |
|
| hsa-miR-3180 |
tttaCCGCCCCccgcccca |
0 | UGGGGCGG | m7b | Disrupted | -0.736000 | -0.473000 |
4.280000 |
|
| hsa-miR-3180-3p |
tttaCCGCCCCccgcccca |
0 | UGGGGCGG | m7b | Disrupted | -0.736000 | -0.473000 |
4.810000 |
|
| hsa-miR-3196 |
tttaCCGCCCCccgcccca |
0 | CGGGGCGG | m7b | Disrupted | -0.757000 | -0.483000 |
6.500000 |
|
| hsa-miR-3656 |
tttaccgcCACCCGCCcca |
0 | GGCGGGUG | m8a | Created | no TS | -0.209000 |
-10.310000 |
|
| hsa-miR-4488 |
tttacCGCCCCCcgcccca |
0 | AGGGGGCG | m7b | Disrupted | -0.187000 | no TS |
1.190000 |
|
| hsa-miR-4697-5p |
tttacCGCCCCCcgcccca |
0 | AGGGGGCG | m7b | Disrupted | -0.205000 | no TS |
13.590000 |
|
| hsa-miR-663a |
tttaccgccCCCCGCCcca |
0 | AGGCGGGG | m7b | (m7b->m6c) | -0.231000 | no TS |
3.130000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr4:g.89954086C>A | COSN15529440 | AOCS-064-1-6 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1228-5p |
ttaCCGCCCACcgccccac |
0 | GUGGGCGG | m8a | Created | no TS | -0.257000 |
4.260000 |
|
| hsa-miR-1908 |
ttaccgccCCCCGCCccac |
0 | CGGCGGGG | m7b | Disrupted | -0.222000 | no TS |
11.380000 |
|
| hsa-miR-3180 |
ttaCCGCCCCccgccccac |
0 | UGGGGCGG | m7b | (m7b->m6b) | -0.736000 | -0.503000 |
3.890000 |
|
| hsa-miR-3180-3p |
ttaCCGCCCCccgccccac |
0 | UGGGGCGG | m7b | (m7b->m6b) | -0.736000 | -0.503000 |
4.420000 |
|
| hsa-miR-3196 |
ttaCCGCCCCccgccccac |
0 | CGGGGCGG | m7b | (m7b->m6b) | -0.757000 | -0.524000 |
2.310000 |
|
| hsa-miR-4488 |
ttacCGCCCCCcgccccac |
0 | AGGGGGCG | m7b | Disrupted | -0.187000 | no TS |
3.220000 |
|
| hsa-miR-4697-5p |
ttacCGCCCCCcgccccac |
0 | AGGGGGCG | m7b | Disrupted | -0.205000 | no TS |
13.590000 |
|
| hsa-miR-541-3p |
ttaccGCCCACCgccccac |
0 | UGGUGGGC | m7b | Created | no TS | -0.164000 | No effect | |
| hsa-miR-654-5p |
ttaccGCCCACCgccccac |
0 | UGGUGGGC | m7b | Created | no TS | -0.145000 |
-0.020000 |
|
| hsa-miR-663a |
ttaccgccCCCCGCCccac |
0 | AGGCGGGG | m7b | Disrupted | -0.231000 | no TS |
14.410000 |
|
| hsa-miR-1228-5p |
ttaCCGCCCACcgccccac |
0 | GUGGGCGG | m8a | Created | no TS | -0.257000 |
4.260000 |
|
| hsa-miR-1908 |
ttaccgccCCCCGCCccac |
0 | CGGCGGGG | m7b | Disrupted | -0.222000 | no TS |
11.380000 |
|
| hsa-miR-3180 |
ttaCCGCCCCccgccccac |
0 | UGGGGCGG | m7b | (m7b->m6b) | -0.736000 | -0.503000 |
3.890000 |
|
| hsa-miR-3180-3p |
ttaCCGCCCCccgccccac |
0 | UGGGGCGG | m7b | (m7b->m6b) | -0.736000 | -0.503000 |
4.420000 |
|
| hsa-miR-3196 |
ttaCCGCCCCccgccccac |
0 | CGGGGCGG | m7b | (m7b->m6b) | -0.757000 | -0.524000 |
2.310000 |
|
| hsa-miR-4488 |
ttacCGCCCCCcgccccac |
0 | AGGGGGCG | m7b | Disrupted | -0.187000 | no TS |
3.220000 |
|
| hsa-miR-4697-5p |
ttacCGCCCCCcgccccac |
0 | AGGGGGCG | m7b | Disrupted | -0.205000 | no TS |
13.590000 |
|
| hsa-miR-541-3p |
ttaccGCCCACCgccccac |
0 | UGGUGGGC | m7b | Created | no TS | -0.164000 | No effect | |
| hsa-miR-654-5p |
ttaccGCCCACCgccccac |
0 | UGGUGGGC | m7b | Created | no TS | -0.145000 |
-0.020000 |
|
| hsa-miR-663a |
ttaccgccCCCCGCCccac |
0 | AGGCGGGG | m7b | Disrupted | -0.231000 | no TS |
14.410000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr4:g.89954472T>A | COSN15460499 | AOCS-139-1-5 | [ovary][NS][other][neoplasm] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-1185-5p |
aatccttTATCCTCTattt |
1 |
AGAGGAUA | m8a | Disrupted | -0.273000 | no TS |
13.600000 |
| hsa-miR-3679-5p |
aatccttTATCCTCtattt |
1 |
UGAGGAUA | m7b | Disrupted | -0.283000 | no TS |
10.950000 |
| hsa-miR-377-5p |
aatcctttAACCTCTattt |
0 | AGAGGUUG | m7a | Created | NA | NA |
-10.560000 |
| hsa-miR-3916 |
aatcctttaTCCTCTattt |
0 | AAGAGGAA | m6b | Disrupted | -0.156000 | no TS |
0.430000 |
| hsa-miR-877-5p |
aatcctttaTCCTCTAttt |
0 | GUAGAGGA | m7b | (m7b->m6c) | -0.276000 | no TS |
1.390000 |
| hsa-miR-1185-5p |
aatccttTATCCTCTattt |
1 |
AGAGGAUA | m8a | Disrupted | -0.273000 | no TS |
13.600000 |
| hsa-miR-3679-5p |
aatccttTATCCTCtattt |
1 |
UGAGGAUA | m7b | Disrupted | -0.283000 | no TS |
10.950000 |
| hsa-miR-377-5p |
aatcctttAACCTCTattt |
0 | AGAGGUUG | m7a | Created | NA | NA |
-10.560000 |
| hsa-miR-3916 |
aatcctttaTCCTCTattt |
0 | AAGAGGAA | m6b | Disrupted | -0.156000 | no TS |
0.430000 |
| hsa-miR-877-5p |
aatcctttaTCCTCTAttt |
0 | GUAGAGGA | m7b | (m7b->m6c) | -0.276000 | no TS |
1.390000 |
| hsa-miR-1185-5p |
aatccttTATCCTCTattt |
1 |
AGAGGAUA | m8a | Disrupted | -0.273000 | no TS |
13.600000 |
| hsa-miR-3679-5p |
aatccttTATCCTCtattt |
1 |
UGAGGAUA | m7b | Disrupted | -0.283000 | no TS |
10.950000 |
| hsa-miR-377-5p |
aatcctttAACCTCTattt |
0 | AGAGGUUG | m7a | Created | NA | NA |
-10.560000 |
| hsa-miR-3916 |
aatcctttaTCCTCTattt |
0 | AAGAGGAA | m6b | Disrupted | -0.156000 | no TS |
0.430000 |
| hsa-miR-877-5p |
aatcctttaTCCTCTAttt |
0 | GUAGAGGA | m7b | (m7b->m6c) | -0.276000 | no TS |
1.390000 |
| hsa-miR-1185-5p |
aatccttTATCCTCTattt |
1 |
AGAGGAUA | m8a | Disrupted | -0.273000 | no TS |
13.600000 |
| hsa-miR-3679-5p |
aatccttTATCCTCtattt |
1 |
UGAGGAUA | m7b | Disrupted | -0.283000 | no TS |
10.950000 |
| hsa-miR-377-5p |
aatcctttAACCTCTattt |
0 | AGAGGUUG | m7a | Created | NA | NA |
-10.560000 |
| hsa-miR-3916 |
aatcctttaTCCTCTattt |
0 | AAGAGGAA | m6b | Disrupted | -0.156000 | no TS |
0.430000 |
| hsa-miR-877-5p |
aatcctttaTCCTCTAttt |
0 | GUAGAGGA | m7b | (m7b->m6c) | -0.276000 | no TS |
1.390000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 89954081 | rs56068881 | C | C |
hsa-miR-1237-5p hsa-miR-3180 hsa-miR-3180-3p hsa-miR-3196 hsa-miR-4488 hsa-miR-4697-5p hsa-miR-6816-5p |
0 |
atttacCGCCCCC atttaCCGCCCCc atttaCCGCCCCc atttaCCGCCCCc atttacCGCCCCC atttacCGCCCCC atttaCCGCCCCc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.205 -0.314 -0.314 -0.272 -0.187 -0.205 -0.282 |
| T |
hsa-miR-486-3p hsa-miR-545-5p |
0 |
atttaCTGCCCCc aTTTACTGccccc |
Created Created |
N N |
-0.187 0.03 |
|||
| 89954082 | rs191120921 | - | G |
hsa-miR-1237-5p hsa-miR-3180 hsa-miR-3180-3p hsa-miR-3196 hsa-miR-328-5p hsa-miR-4488 hsa-miR-4697-5p hsa-miR-6816-5p hsa-miR-6885-5p |
0 |
tttacCGCCCCCc tttaCCGCCCCcc tttaCCGCCCCcc tttaCCGCCCCcc tttaccGCCCCCC tttacCGCCCCCc tttacCGCCCCCc tttaCCGCCCCcc tttaccGCCCCCC |
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown |
N N N N N N N N N |
-0.205 -0.301 -0.301 -0.291 -0.195 -0.187 -0.205 -0.28 -0.195 |
| A |
hsa-miR-1293 hsa-miR-4483 hsa-miR-4651 hsa-miR-608 hsa-miR-6752-5p hsa-miR-6842-5p hsa-miR-7110-5p |
0 |
tttACCACCCccc tttACCACCCccc tttaCCACCCCcc tttaCCACCCCcc tttacCACCCCCc tttacCACCCCCc tttacCACCCCCc |
Unknown Unknown Unknown Unknown Unknown Unknown Unknown |
N N N N N N N |
-0.189 -0.17 -0.197 -0.197 -0.165 -0.156 -0.165 |
|||
| 89954477 | rs185984076 | T | T |
hsa-miR-3121-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-6859-5p hsa-miR-877-5p |
0 |
atccTCTATTTgt aTCCTCTAtttgt aTCCTCTAtttgt aTCCTCTAtttgt aTCCTCTAtttgt |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.078 -0.163 -0.156 -0.156 -0.276 |
| C |
hsa-miR-4694-3p hsa-miR-4802-5p hsa-miR-6894-5p hsa-miR-7154-3p hsa-miR-765 hsa-miR-766-5p |
0 |
atccTCCATTTgt atCCTCCATttgt ATCCTCCAtttgt aTCCTCCAtttgt aTCCTCCAtttgt aTCCTCCAtttgt |
Created Created Created Created Created Created |
N N N N N N |
-0.143 -0.295 -0.454 -0.202 -0.198 -0.184 |