SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004994
Gene Symbol:	MMP9
Description:	Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (MMP9), mRNA.
Gene Location:	chr20(+):44637546-44645200
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr20:g.46016446A>G			COSN1249501		HCC18T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-324-5p	ttgccGGATGCaaactggt	0	CGCAUCCC	m6b	Created	no TS	-0.170000	-8.750000
hsa-miR-3680-3p	ttgccggATGCAAActggt	0	UUUUGCAU	m7b	Created	no TS	-0.028000	-1.230000
hsa-miR-3713	ttgcCGGATACaaactggt	0	GGUAUCCG	m7b	Disrupted	-0.392000	no TS	2.840000
hsa-miR-324-5p	ttgccGGATGCaaactggt	0	CGCAUCCC	m6b	Created	no TS	-0.170000	-8.750000
hsa-miR-3680-3p	ttgccggATGCAAActggt	0	UUUUGCAU	m7b	Created	no TS	-0.028000	-1.230000
hsa-miR-3713	ttgcCGGATACaaactggt	0	GGUAUCCG	m7b	Disrupted	-0.392000	no TS	2.840000
hsa-miR-324-5p	ttgccGGATGCaaactggt	0	CGCAUCCC	m6b	Created	no TS	-0.17	-8.75
hsa-miR-3680-3p	ttgccggATGCAAActggt	0	UUUUGCAU	m7b	Created	no TS	-0.028	-1.23
hsa-miR-3713	ttgcCGGATACaaactggt	0	GGUAUCCG	m7b	Disrupted	-0.392	no TS	2.84

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
46016444	rs199561934	A	A	hsa-miR-3149 hsa-miR-3713	7 5	tgccggATACAAA tgcCGGATACAaa	Disrupted Disrupted	N N	0.017 -0.392
			G	hsa-miR-941	6	tGCCGGGTAcaaa	Created	N	-0.645

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