SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002422
Gene Symbol:	MMP3
Description:	Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3), mRNA.
Gene Location:	chr11(-):102706527-102714342
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.102835827A>G			COSN1509725		RK209_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3671	tgctTATTTGATaaagacg	0	AUCAAAUA	m8a	Created	no TS	-0.162000	-2.510000
hsa-miR-374a-3p	tgcttattTGATAAagacg	0	CUUAUCAG	m6b	Created	no TS	-0.057000	-4.050000
hsa-miR-4477a	tgcttatTTAATAaagacg	0	CUAUUAAG	m6b	Disrupted	0.011000	no TS	2.210000
hsa-miR-5692a	tgcTTATTTGataaagacg	0	CAAAUAAU	m7a	(m6b->m7a)	0.033000	no TS	0.810000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.102835973G>A			COSN5255840		HCC152		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3128	tatcTTGCCAGtcattttt	0	UCUGGCAA	m7b	Created	no TS	-0.203000	-0.360000
hsa-miR-3128	tatcTTGCCAGtcattttt	0	UCUGGCAA	m7b	Created	no TS	-0.203000	-0.360000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.102836098G>A			COSN5263861		SNUH_G12_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-106a-5p	acaatatggGCACTTTaaa	1	AAAAGUGC	m7b	(m7b->m6b)	-0.315000	-0.083000	3.780000
hsa-miR-106b-5p	acaatatggGCACTTTAaa	1	UAAAGUGC	m8a	(m8a->m7a)	-0.315000	-0.083000	3.380000
hsa-miR-17-5p	acaatatggGCACTTTaaa	1	CAAAGUGC	m7b	(m7b->m6b)	-0.315000	-0.083000	3.780000
hsa-miR-20a-5p	acaatatggGCACTTTAaa	1	UAAAGUGC	m8a	(m8a->m7a)	-0.315000	-0.083000	5.580000
hsa-miR-20b-5p	acaatatggGCACTTTaaa	1	CAAAGUGC	m7b	(m7b->m6b)	-0.315000	-0.083000	4.780000
hsa-miR-371b-3p	acaatatGGGCACTTtaaa	1	AAGUGCCC	m8a	Disrupted	-0.393000	no TS	0.100000
hsa-miR-372	acaatatggGCACTTTaaa	0	AAAGUGCU	m7a	(m7a->m6a)	NA	NA	0.910000
hsa-miR-519a-3p	acaatatggGCACTTTaaa	0	AAAGUGCA	m7a	(m7a->m6a)	NA	NA	1.210000
hsa-miR-519b-3p	acaatatggGCACTTTaaa	0	AAAGUGCA	m7a	(m7a->m6a)	NA	NA	1.010000
hsa-miR-519c-3p	acaatatggGCACTTTaaa	0	AAAGUGCA	m7a	(m7a->m6a)	NA	NA	-1.430000
hsa-miR-519d	acaatatggGCACTTTaaa	1	CAAAGUGC	m7b	(m7b->m6b)	-0.283000	-0.073000	0.050000
hsa-miR-520a-3p	acaatatggGCACTTTaaa	0	AAAGUGCU	m7a	(m7a->m6a)	NA	NA	No effect
hsa-miR-520b	acaatatggGCACTTTaaa	0	AAAGUGCU	m7a	(m7a->m6a)	NA	NA	0.030000
hsa-miR-520c-3p	acaatatggGCACTTTaaa	0	AAAGUGCU	m7a	(m7a->m6a)	NA	NA	0.010000
hsa-miR-520d-3p	acaatatggGCACTTTaaa	0	AAAGUGCU	m7a	(m7a->m6a)	NA	NA	No effect
hsa-miR-520e	acaatatggGCACTTTaaa	0	AAAGUGCU	m7a	(m7a->m6a)	NA	NA	No effect
hsa-miR-526b-3p	acaatatggGCACTTTaaa	1	GAAAGUGC	m7b	(m7b->m6b)	-0.283000	-0.073000	3.774000
hsa-miR-93-5p	acaatatggGCACTTTaaa	1	CAAAGUGC	m7b	(m7b->m6b)	-0.315000	-0.083000	0.680000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
102835973	rs3025079	G
			A	hsa-miR-3128 hsa-miR-31-5p hsa-miR-6809-5p	2 3 3	cTTGCCAGtcatt CTTGCCAgtcatt CTTGCCAgtcatt	Created Created Created	N N N	-0.203 -0.189 -0.164

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