SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002421
Gene Symbol:	MMP1
Description:	Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 2, mRNA.
Gene Location:	chr11(-):102660640-102668966
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.102790349C>T			COSN164034		GC8_T		[stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-22-5p	cctGAAGAACTgtctattt	4	AGUUCUUC	m8a	Disrupted	-0.209000	-0.037000	0.160000
hsa-miR-4277	cctgaAGAACTGtctattt	0	GCAGUUCU	m7b	Disrupted	-0.191000	no TS	2.250000
hsa-miR-4524b-3p	cctgaagaaCTGTCTattt	0	GAGACAGG	m6b	Disrupted	-0.133000	no TS	1.990000
hsa-miR-4645-3p	cctgaagaACTGTCTattt	0	AGACAGUA	m7a	Disrupted	NA	NA	No effect
hsa-miR-5584-3p	cctgAAGAACTgtctattt	0	UAGUUCUU	m7b	Disrupted	-0.088000	no TS	1.560000
hsa-miR-22-5p	cctGAAGAACTgtctattt	0	AGUUCUUC	m8a	Disrupted	-0.209	-0.037	0.16
hsa-miR-4277	cctgaAGAACTGtctattt	0	GCAGUUCU	m7b	Disrupted	-0.191	no TS	2.25
hsa-miR-4524b-3p	cctgaagaaCTGTCTattt	0	GAGACAGG	m6b	Disrupted	-0.133	no TS	1.99
hsa-miR-4645-3p	cctgaagaACTGTCTattt	0	AGACAGUA	m7a	Disrupted	NA	NA	No effect
hsa-miR-5584-3p	cctgAAGAACTgtctattt	0	UAGUUCUU	m7b	Disrupted	-0.088	no TS	1.56

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
102790349	rs2239008	C	C	hsa-miR-22-5p hsa-miR-4277 hsa-miR-4524b-3p hsa-miR-5584-3p	3 1 1 2	GAAGAACtgtcta gaAGAACTGtcta gaagaaCTGTCTA gAAGAACTgtcta	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.172 -0.191 -0.133 -0.088

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