| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_001042467 |
|---|---|
| Gene Symbol: | MLPH |
| Description: | Homo sapiens melanophilin (MLPH), transcript variant 2, mRNA. |
| Gene Location: | chr2(+):238395877-238463961 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr2:g.237553617A>C | COSN7800948 | PCSI_0062_Pa_X | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3141 |
agacagagCCGCCCTgcac |
0 | GAGGGCGG | m7b | Created | no TS | -0.254000 | No effect | |
| hsa-miR-4446-3p |
agacagagCAGCCCTGcac |
2 |
CAGGGCUG | m8a | Disrupted | -0.335000 | -0.165000 | No effect | |
| hsa-miR-5691 |
agaCAGAGCAgccctgcac |
3 |
UUGCUCUG | m7b | (m7b->m6b) | -0.134000 | no TS | No effect | |
| hsa-miR-760 |
agaCAGAGCCGccctgcac |
2 |
CGGCUCUG | m8a | Created | -0.078000 | -0.285000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr2:g.237553681A>G | COSN166443 | GC8_T | [stomach][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-let-7a-2-3p |
ctttccaCTGTACAcagtc |
0 | CUGUACAG | m7b | Created | no TS | -0.141000 |
-0.120000 |
|
| hsa-let-7g-3p |
ctttccaCTGTACAcagtc |
0 | CUGUACAG | m7b | Created | no TS | -0.131000 |
-0.010000 |
|
| hsa-miR-223-5p |
ctttccactATACACagtc |
0 | CGUGUAUU | m6b | Disrupted | -0.061000 | no TS |
5.620000 |
|
| hsa-miR-3177-5p |
ctttccacTGTACACAgtc |
0 | UGUGUACA | m8a | Created | no TS | -0.282000 |
-1.120000 |
|
| hsa-miR-4460 |
ctttCCACTATacacagtc |
0 | AUAGUGGU | m7a | Disrupted | NA | NA |
0.010000 |
|
| hsa-miR-4727-3p |
ctttCCACTATacacagtc |
0 | AUAGUGGG | m7a | Disrupted | NA | NA |
7.010000 |
|
| hsa-let-7a-2-3p |
ctttccaCTGTACAcagtc |
0 | CUGUACAG | m7b | Created | no TS | -0.141 |
-0.12 |
|
| hsa-let-7g-3p |
ctttccaCTGTACAcagtc |
0 | CUGUACAG | m7b | Created | no TS | -0.131 |
-0.01 |
|
| hsa-miR-223-5p |
ctttccactATACACagtc |
0 | CGUGUAUU | m6b | Disrupted | -0.061 | no TS |
5.62 |
|
| hsa-miR-3177-5p |
ctttccacTGTACACAgtc |
0 | UGUGUACA | m8a | Created | no TS | -0.282 |
-1.12 |
|
| hsa-miR-4460 |
ctttCCACTATacacagtc |
0 | AUAGUGGU | m7a | Disrupted | NA | NA |
0.01 |
|
| hsa-miR-4727-3p |
ctttCCACTATacacagtc |
0 | AUAGUGGG | m7a | Disrupted | NA | NA |
7.01 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr2:g.237553860A>G | COSN4991028 | SS6003308 | [oesophagus][NS][carcinoma][adenocarcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-186-3p |
cttccCTTTGGGacaatgt |
0 | GCCCAAAG | m7b | Created | no TS | -0.210000 |
-1.360000 |
| hsa-miR-2355-3p |
cttccctttAGGACAATgt |
2 |
AUUGUCCU | m8a | (m8a->m7b) | -0.172000 | no TS | No effect |
| hsa-miR-4433-5p |
cttcccttTGGGACaatgt |
0 | CGUCCCAC | m6b | Created | no TS | -0.167000 | No effect |
| hsa-miR-4509 |
cttcCCTTTAGgacaatgt |
4 |
ACUAAAGG | m7b | Disrupted | -0.052000 | 0.048000 |
0.090000 |
| hsa-miR-4646-3p |
cttccctttGGGACAATgt |
0 | AUUGUCCC | m8a | (m7b->m8a) | no TS | -0.221000 |
-0.080000 |
| hsa-miR-676-3p |
cttcccttTAGGACAatgt |
2 |
CUGUCCUA | m7b | Disrupted | -0.341000 | no TS |
1.620000 |
| hsa-miR-186-3p |
cttccCTTTGGGacaatgt |
0 | GCCCAAAG | m7b | Created | no TS | -0.210000 |
-1.360000 |
| hsa-miR-2355-3p |
cttccctttAGGACAATgt |
2 |
AUUGUCCU | m8a | (m8a->m7b) | -0.172000 | no TS | No effect |
| hsa-miR-4433-5p |
cttcccttTGGGACaatgt |
0 | CGUCCCAC | m6b | Created | no TS | -0.167000 | No effect |
| hsa-miR-4509 |
cttcCCTTTAGgacaatgt |
4 |
ACUAAAGG | m7b | Disrupted | -0.052000 | 0.048000 |
0.090000 |
| hsa-miR-4646-3p |
cttccctttGGGACAATgt |
0 | AUUGUCCC | m8a | (m7b->m8a) | no TS | -0.221000 |
-0.080000 |
| hsa-miR-676-3p |
cttcccttTAGGACAatgt |
2 |
CUGUCCUA | m7b | Disrupted | -0.341000 | no TS |
1.620000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 237553611 | rs200811367 | C | C |
hsa-miR-3120-5p hsa-miR-3194-3p hsa-miR-5691 hsa-miR-593-3p hsa-miR-6805-3p hsa-miR-6818-3p hsa-miR-6888-3p hsa-miR-6895-3p |
1 3 3 1 3 1 1 1 |
gagAGACAGAgca gagagaCAGAGCA gagagaCAGAGCA gAGAGACAgagca gagagaCAGAGCA gAGAGACAgagca gagAGACAGAgca GAGAGACAgagca |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N |
-0.068 -0.11 -0.134 No Change -0.125 No Change -0.089 No Change |
| T |
hsa-miR-1301-5p hsa-miR-3675-3p hsa-miR-6502-5p |
3 1 3 |
gagagaTAGAGCA gAGAGATAgagca gagagaTAGAGCA |
Created Created Created |
N N N |
-0.102 No Change -0.119 |
|||
| 237553621 | rs11901745 | C | C |
hsa-miR-1909-3p hsa-miR-4446-3p hsa-miR-6132 hsa-miR-6722-3p hsa-miR-6829-5p hsa-miR-6836-5p |
2 2 2 2 3 4 |
gcagCCCTGCAct gCAGCCCTgcact gcaGCCCTGCAct gcagCCCTGCAct GCAGCCCtgcact gcaGCCCTGCAct |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.156 -0.17 -0.458 -0.153 -0.241 -0.458 |
| T |
hsa-miR-130a-3p hsa-miR-130b-3p hsa-miR-301a-3p hsa-miR-301b hsa-miR-3666 hsa-miR-4295 hsa-miR-454-3p hsa-miR-4708-3p |
3 3 3 3 3 3 3 2 |
gcagccTTGCACT gcagccTTGCACT gcagccTTGCACT gcagccTTGCACT gcagccTTGCACT gcagccTTGCACT gcagccTTGCACT gcaGCCTTGCAct |
Created Created Created Created Created Created Created Created |
N N N N N N N N |
-0.071 -0.089 -0.117 -0.117 -0.089 -0.098 -0.126 -0.506 |
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| 237553681 | rs8260 | G | A |
hsa-miR-223-5p hsa-miR-3681-5p hsa-miR-6849-5p |
0 |
tccactATACACA TCCACTAtacaca TCCACTAtacaca |
Created Created Created |
N N N |
-0.061 -0.166 -0.163 |
| G |
hsa-let-7a-2-3p hsa-let-7g-3p hsa-miR-3177-5p |
0 |
tccaCTGTACAca tccaCTGTACAca tccacTGTACACA |
Disrupted Disrupted Disrupted |
N N N |
-0.141 -0.131 -0.282 |
|||
| 237553682 | rs74815149 | T | T |
hsa-miR-223-5p |
0 |
ccactATACACAg |
Disrupted |
N |
-0.061 |
| C |
hsa-miR-142-3p hsa-miR-6073 hsa-miR-6867-5p |
0 |
cCACTACAcacag cCACTACAcacag ccactACACACAg |
Created Created Created |
N N N |
-0.13 -0.136 -0.08 |
|||
| 237553861 | rs188841860 | G | G |
hsa-miR-2355-3p hsa-miR-4509 hsa-miR-5009-3p hsa-miR-676-3p |
2 4 4 2 |
cctttAGGACAAt CCTTTAGgacaat ccTTTAGGAcaat ccttTAGGACAAt |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.172 -0.1 -0.049 -0.341 |
| A |
hsa-miR-200c-5p hsa-miR-302a-5p hsa-miR-511-5p hsa-miR-550a-3p |
2 4 2 2 |
ccttTAAGACAat ccTTTAAGAcaat cctttAAGACAAt ccttTAAGACAat |
Created Created Created Created |
N N N N |
-0.092 0.039 -0.061 -0.088 |