SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001195432
Gene Symbol: MLF1
Description: Homo sapiens myeloid leukemia factor 1 (MLF1), transcript variant 3, mRNA.
Gene Location: chr3(+):158288952-158324249
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.158605377T>A COSN9139321 AOCS-155-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3685 tttTAGGAAAaaaattttg
 0 UUUCCUAC m7a (m6a->m7a) no TS -0.112000 -0.370000
hsa-miR-384 tttTAGGAATaaaattttg
 0 AUUCCUAG m7a (m7a->m6a) no TS -0.110000 -0.360000
hsa-miR-590-3p ttttaggaaTAAAATTttg
 5
 UAAUUUUA m7b (m7b->m6c) -0.067000 -0.028000 0.940000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.158605424T>C COSN1270578 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-5p tatttaatGCAAAACTctt
 4
 AGUUUUGC m8a Created -0.178000 -0.386000 -0.060000
hsa-miR-19b-1-5p tatttaatGCAAAACTctt
 4
 AGUUUUGC m8a Created -0.178000 -0.386000 -1.640000
hsa-miR-19b-2-5p tatttaatGCAAAACTctt
 4
 AGUUUUGC m8a Created -0.178000 -0.386000 -1.370000
hsa-miR-323a-3p tattTAATGTaaaactctt
 4
 CACAUUAC m6b Disrupted -0.068000 -0.001000 0.240000
hsa-miR-33a-5p tatttAATGCAaaactctt
 2
 GUGCAUUG m6b Created -0.143000 -0.260000 -1.320000
hsa-miR-33b-5p tatttAATGCAaaactctt
 2
 GUGCAUUG m6b Created -0.143000 -0.260000 -0.140000
hsa-miR-3680-3p tatttaATGCAAAActctt
 5
 UUUUGCAU m8a Created -0.185000 -0.428000 -1.940000
hsa-miR-557 tatttaaTGCAAAactctt
 0 GUUUGCAC m6b Created no TS -0.087000 -9.150000
hsa-miR-19a-5p tatttaatGCAAAACTctt
 0 AGUUUUGC m8a Created -0.178 -0.386 2.76
hsa-miR-19b-1-5p tatttaatGCAAAACTctt
 0 AGUUUUGC m8a Created -0.178 -0.386 -1.64
hsa-miR-19b-2-5p tatttaatGCAAAACTctt
 0 AGUUUUGC m8a Created -0.178 -0.386 -1.37
hsa-miR-323a-3p tattTAATGTaaaactctt
 0 CACAUUAC m6b Disrupted -0.068 -0.001 0.24
hsa-miR-33a-5p tatttAATGCAaaactctt
 0 GUGCAUUG m6b Created -0.143 -0.26 -1.32
hsa-miR-33b-5p tatttAATGCAaaactctt
 0 GUGCAUUG m6b Created -0.143 -0.26 -0.14
hsa-miR-3680-3p tatttaATGCAAAActctt
 0 UUUUGCAU m8a Created -0.185 -0.428 -1.94
hsa-miR-557 tatttaaTGCAAAactctt
 0 GUUUGCAC m6b Created no TS -0.087 -9.15

Mutation Mutation ID Sample Name Cancer Type
chr3:g.158605554A>C 13_165 SJMB025_D Medulloblastoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-944 tcacttATAATTagttata
 0 AAAUUAUU m6b Disrupted 0.022 -0.026 0.01

Mutation Mutation ID Sample Name Cancer Type
chr3:g.158605811C>A COSN9761206 C0007T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-493-5p gctaATGTACAtgattgtt
 3
 UUGUACAU m7b Disrupted -0.139000 no TS 6.220000
hsa-miR-5696 gctaatgTAAATGAttgtt
 0 CUCAUUUA m7b Created no TS -0.025000 -2.140000
hsa-miR-96-3p gctaatgtACATGATTgtt
 2
 AAUCAUGU m8a Disrupted -0.161000 no TS 10.850000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.158605866C>T COSN9139322 AOCS-147-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3653 tattacaTTCTTAatattc
 3
 CUAAGAAG m6b Disrupted -0.150000 -0.148000 0.820000
hsa-miR-3658 tattacaTTCTTAAtattc
 4
 UUUAAGAA m7b Disrupted -0.047000 0.017000 0.170000
hsa-miR-4477a tattacattCTTAATAttc
 5
 CUAUUAAG m7b (m7b->m6c) -0.101000 -0.051000 No effect
hsa-miR-548c-3p tattacATTTTTaatattc
 0 CAAAAAUC m6b Created no TS 0.094000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.158605933C>T MLF1_E9_UTR_3 SJHYPO046_D Hypodiploid_ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4428 ttctacTCTCCTTtcccac
 6
 CAAGGAGA m7b Disrupted -0.088 no TS 2.58
hsa-miR-5192 ttctACTCTCCTttcccac
 1
 AGGAGAGU m8a Disrupted -0.192 no TS 1.67
hsa-miR-5197-3p ttctaCTCTTCTTtcccac
 0 AAGAAGAG m8a Created no TS -0.116 -0.01


Mutation Mutation ID Sample Name Cancer Type
chr3:g.158606098T>C COSN9139323 AOCS-162-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.158606286C>A COSN1924249 RK107_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1262 gaaaaaagCACCCAaaaat
 0 AUGGGUGA m6b Created no TS -0.208000 -1.410000
hsa-miR-1275 gaaaaaagCCCCCAaaaat
 1
 GUGGGGGA m6b Disrupted -0.240000 no TS 0.030000
hsa-miR-3119 gaaAAAAGCCcccaaaaat
 1
 UGGCUUUU m7b (m7b->m6b) -0.275000 -0.088000 6.100000
hsa-miR-4260 gaaaaaagcCCCCAAaaat
 1
 CUUGGGGC m6b Disrupted -0.186000 no TS 1.890000
hsa-miR-4488 gaaaaaaGCCCCCaaaaat
 0 AGGGGGCG m6b Disrupted -0.300000 no TS 14.370000
hsa-miR-450a-3p gaaaaaagcCCCCAAaaat
 1
 AUUGGGGA m6b Disrupted -0.184000 no TS 0.120000
hsa-miR-4665-5p gaaaaaagCCCCCAaaaat
 1
 CUGGGGGA m6b Disrupted -0.240000 no TS No effect
hsa-miR-4697-5p gaaaaaaGCCCCCaaaaat
 0 AGGGGGCG m6b Disrupted -0.300000 no TS 8.530000
hsa-miR-4701-3p gaaaaaagCACCCAaaaat
 0 AUGGGUGA m6b Created no TS -0.208000 -2.460000
hsa-miR-5572 gaaaaaagcCCCCAAaaat
 1
 GUUGGGGU m6b Disrupted -0.180000 no TS 1.880000
hsa-miR-1262 gaaaaaagCACCCAaaaat
 0 AUGGGUGA m6b Created no TS -0.208 -1.41
hsa-miR-1275 gaaaaaagCCCCCAaaaat
 0 GUGGGGGA m6b Disrupted -0.24 no TS 0.03
hsa-miR-3119 gaaAAAAGCCcccaaaaat
 1
 UGGCUUUU m7b (m7b->m6b) -0.275 -0.088 6.1
hsa-miR-4260 gaaaaaagcCCCCAAaaat
 0 CUUGGGGC m6b Disrupted -0.186 no TS 1.89
hsa-miR-4488 gaaaaaaGCCCCCaaaaat
 0 AGGGGGCG m6b Disrupted -0.3 no TS 14.37
hsa-miR-450a-3p gaaaaaagcCCCCAAaaat
 0 AUUGGGGA m6b Disrupted -0.184 no TS 0.12
hsa-miR-4665-5p gaaaaaagCCCCCAaaaat
 0 CUGGGGGA m6b Disrupted -0.24 no TS No effect
hsa-miR-4697-5p gaaaaaaGCCCCCaaaaat
 0 AGGGGGCG m6b Disrupted -0.3 no TS 8.53
hsa-miR-4701-3p gaaaaaagCACCCAaaaat
 0 AUGGGUGA m6b Created no TS -0.208 -2.46
hsa-miR-5572 gaaaaaagcCCCCAAaaat
 0 GUUGGGGU m6b Disrupted -0.18 no TS 1.88

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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