SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002412
Gene Symbol: MGMT
Description: Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA.
Gene Location: chr10(+):131265453-131565783
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr10:g.129767245G>A COSN1477170 RK058_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3692-3p agtgagTGTGGAAggcctg
 1
 GUUCCACA m7b Disrupted -0.080000 no TS 2.800000
hsa-miR-4297 agtgagtgtGGAAGGCctg
 0 UGCCUUCC m7b (m7b->m6c) -0.178000 no TS 4.390000
hsa-miR-5581-5p agtgagtgtGGAAGGCctg
 0 AGCCUUCC m7b (m7b->m6c) -0.178000 no TS 6.740000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
129767245 rs7896488 G G hsa-miR-3692-3p
hsa-miR-4297
hsa-miR-5581-5p
1
4
4
 gagTGTGGAAggc
gagtgtGGAAGGC
gagtgtGGAAGGC
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.08
-0.178
-0.178

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