SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_015335
Gene Symbol: MED13L
Description: Homo sapiens mediator complex subunit 13-like (MED13L), mRNA.
Gene Location: chr12(-):116396380-116714991
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.115959344C>T COSN5316082 RK038_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3940-5p cctagaAACCCAattctaa
 10
 GUGGGUUG m6b Disrupted -0.159000 -0.072000 0.010000
hsa-miR-4507 cctagaAACCCAattctaa
 10
 CUGGGUUG m6b Disrupted -0.162000 -0.075000 No effect
hsa-miR-629-5p cctagAAACCCAattctaa
 13
 UGGGUUUA m7a Disrupted -0.144000 -0.059000 2.900000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960063G>A COSN5316083 RK076_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-616-3p gcattAATGACTaattgaa
 0 AGUCAUUG m7a Created NA NA -5.750000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960064G>T COSN5316084 RK076_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3908 agcattaATTGCTaattga
 0 GAGCAAUG m6b Created no TS -0.006000 -0.010000
hsa-miR-3942-5p agcattaATTGCTaattga
 0 AAGCAAUA m6b Created no TS -0.009000 -0.080000
hsa-miR-4703-5p agcattaATTGCTAattga
 0 UAGCAAUA m7a Created no TS -0.012000 0.070000
hsa-miR-4766-3p agcattaATTGCTAattga
 0 AUAGCAAU m7b Created no TS -0.120000 -0.860000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960276A>G COSN1558671 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3661 ttggaagCCAGGTCtctcc
 14
 UGACCUGG m7b Disrupted -0.114000 no TS 0.880000
hsa-miR-631 ttggaagCCAGGTCTctcc
 14
 AGACCUGG m8a Disrupted -0.114000 no TS 1.410000
hsa-miR-769-5p ttggaagccAGGTCTCtcc
 14
 UGAGACCU m7b (m7b->m6b) -0.072000 no TS 0.710000
hsa-miR-941 ttggaaGCCGGGTctctcc
 0 CACCCGGC m7b Created no TS -0.258000 -5.390000
hsa-miR-3661 ttggaagCCAGGTCtctcc
 0 UGACCUGG m7b Disrupted -0.114 no TS 0.88
hsa-miR-631 ttggaagCCAGGTCTctcc
 0 AGACCUGG m8a Disrupted -0.114 no TS 1.41
hsa-miR-769-5p ttggaagccAGGTCTCtcc
 0 UGAGACCU m7b (m7b->m6b) -0.072 no TS 0.71
hsa-miR-941 ttggaaGCCGGGTctctcc
 0 CACCCGGC m7b Created no TS -0.258 -5.39

Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960775C>T COSN8538480 tumor_4166706 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4517 ggttTCATATTggggtttc
 0 AAAUAUGA m7b Created no TS 0.000000 -0.030000


Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960960C>T ICGC_474725 TCGA-D5-6539-01A-11D-1719-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960961G>A ICGC_2974 TCGA-02-0010-01A-01W-0189-08 GlioblastomaMultiforme(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-720 ttttCAGCGAGAaacagaa
 0 UCUCGCUG m8a Created no TS -0.492 -2.28

Mutation Mutation ID Sample Name Cancer Type
chr12:g.115960992G>A COSN7311956 8052570 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1343 tggtcCCCAGGAagtggtg
 2
 CUCCUGGG m7b Disrupted -0.275000 no TS 0.040000
hsa-miR-4260 tggtCCCCAAGaagtggtg
 2
 CUUGGGGC m7a Created -0.174000 -0.178000 No effect
hsa-miR-450a-3p tggTCCCCAAgaagtggtg
 0 AUUGGGGA m7b (m6c->m7b) no TS -0.113000 -0.410000
hsa-miR-4667-5p tggTCCCCAGgaagtggtg
 2
 ACUGGGGA m7b (m7b->m6c) -0.124000 no TS No effect
hsa-miR-4700-5p tggTCCCCAGgaagtggtg
 2
 UCUGGGGA m7b (m7b->m6c) -0.124000 no TS No effect
hsa-miR-635 tggtcCCCAAGaagtggtg
 0 ACUUGGGC m6b Created no TS -0.098000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.115961089T>C COSN7311957 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-514a-5p ttaCCAGAGTgactccttg
 0 UACUCUGG m7b (m7b->m6c) -0.240000 no TS 1.100000
hsa-miR-668 ttaccaGAGTGACtccttg
 9
 UGUCACUC m7b Disrupted -0.202000 no TS 6.900000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
115961006 rs188386240 A A hsa-miR-1227-5p
hsa-miR-1273g-5p
hsa-miR-140-5p
hsa-miR-4260
hsa-miR-92a-1-5p
2
7
7
2
2
 GCCCCAAccactg
gcccCAACCACtg
gccccAACCACTg
GCCCCAAccactg
gcCCCAACCActg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.153
-0.077
-0.046
-0.174
-0.287
G hsa-miR-3652
hsa-miR-4430
hsa-miR-4505
hsa-miR-4731-5p
hsa-miR-5693
hsa-miR-5787
hsa-miR-6842-3p
2
2
2
2
9
2
2
 gccCCAGCCActg
gccCCAGCCActg
gcCCCAGCCActg
gCCCCAGCcactg
gccccaGCCACTG
gcCCCAGCCActg
gccCCAGCCActg
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.101
-0.101
-0.317
-0.175
-0.109
-0.296
-0.109

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