SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004991
Gene Symbol: MECOM
Description: Homo sapiens MDS1 and EVI1 complex locus (MECOM), transcript variant 1, mRNA.
Gene Location: chr3(-):168801286-169381563
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.169083875T>G COSN6742835 RK081_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-205-3p ataCTGAAATCgattcaat
 16
 GAUUUCAG m8a Disrupted -0.121000 -0.031000 0.010000
hsa-miR-30a-3p atACTGAAAGcgattcaat
 13
 CUUUCAGU m8a (m7b->m8a) -0.113000 -0.085000 No effect
hsa-miR-30d-3p atACTGAAAGcgattcaat
 13
 CUUUCAGU m8a (m7b->m8a) -0.113000 -0.085000 -0.060000
hsa-miR-30e-3p atACTGAAAGcgattcaat
 13
 CUUUCAGU m8a (m7b->m8a) -0.113000 -0.085000 0.010000
hsa-miR-4315 atactGAAAGCGattcaat
 0 CCGCUUUC m7b Created no TS -0.444000 -2.230000
hsa-miR-4790-5p atactgAAAGCGATtcaat
 0 AUCGCUUU m8a Created no TS -0.254000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.169084194T>C COSN1929812 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-25-3p aaatcctTGCAATaacatc
 0 CAUUGCAC m6b Created no TS -0.029000 -0.770000
hsa-miR-32-5p aaatcctTGCAATAacatc
 0 UAUUGCAC m7a Created no TS -0.029000 No effect
hsa-miR-363-3p aaatcctTGCAATaacatc
 0 AAUUGCAC m6b Created no TS -0.032000 -0.720000
hsa-miR-367-3p aaatcctTGCAATaacatc
 0 AAUUGCAC m6b Created no TS -0.042000 -1.380000
hsa-miR-4708-3p aaatCCTTGCaataacatc
 0 AGCAAGGC m6b Created no TS -0.134000 -10.360000
hsa-miR-556-3p aaatccttGTAATAacatc
 13
 AUAUUACC m6b Disrupted 0.017000 no TS 0.050000
hsa-miR-624-3p aaatCCTTGTaataacatc
 13
 CACAAGGU m6b Disrupted -0.100000 no TS 4.940000
hsa-miR-92a-3p aaatcctTGCAATAacatc
 0 UAUUGCAC m7a Created no TS -0.032000 -0.060000
hsa-miR-92b-3p aaatcctTGCAATAacatc
 0 UAUUGCAC m7a Created no TS -0.032000 -0.150000
hsa-miR-25-3p aaatcctTGCAATaacatc
 0 CAUUGCAC m6b Created no TS -0.029 -0.77
hsa-miR-32-5p aaatcctTGCAATAacatc
 0 UAUUGCAC m7a Created no TS -0.029 No effect
hsa-miR-363-3p aaatcctTGCAATaacatc
 0 AAUUGCAC m6b Created no TS -0.032 -0.72
hsa-miR-367-3p aaatcctTGCAATaacatc
 0 AAUUGCAC m6b Created no TS -0.042 -1.38
hsa-miR-4708-3p aaatCCTTGCaataacatc
 0 AGCAAGGC m6b Created no TS -0.134 -10.36
hsa-miR-556-3p aaatccttGTAATAacatc
 0 AUAUUACC m6b Disrupted 0.017 no TS 0.05
hsa-miR-624-3p aaatCCTTGTaataacatc
 0 CACAAGGU m6b Disrupted -0.1 no TS 4.94
hsa-miR-92a-3p aaatcctTGCAATAacatc
 0 UAUUGCAC m7a Created no TS -0.032 -0.06
hsa-miR-92b-3p aaatcctTGCAATAacatc
 0 UAUUGCAC m7a Created no TS -0.032 -0.15

Mutation Mutation ID Sample Name Cancer Type
chr3:g.169084297T>C COSN8911609 SS6003109 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-101-3p atgtgtaTACTGTAaacta
 0 UACAGUAC m7a Created no TS -0.060000 -0.010000
hsa-miR-144-3p atgtgtATACTGTAaacta
 0 UACAGUAU m8a Created no TS -0.158000 -0.020000
hsa-miR-338-5p atgtgtATATTGTaaacta
 17
 AACAAUAU m7b Disrupted -0.055000 no TS 0.370000
hsa-miR-4789-5p atGTGTATACtgtaaacta
 19
 GUAUACAC m8a (m7b->m8a) -0.147000 -0.120000 0.150000
hsa-miR-582-5p atgtgtatACTGTAAacta
 0 UUACAGUU m7a Created -0.141000 -0.197000 0.030000


Mutation Mutation ID Sample Name Cancer Type
chr3:g.169084404G>A COSN6742836 RK183_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.169084475T>C COSN9532519 AOCS-137-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2054 tgcttttaATTACAGattt
 0 CUGUAAUA m7a Disrupted NA NA 0.040000
hsa-miR-20b-3p tgcttttaACTACAGattt
 0 ACUGUAGU m7b Created no TS -0.360000 -0.470000
hsa-miR-3607-3p tgcttttaaTTACAGattt
 11
 ACUGUAAA m6b Disrupted -0.074000 no TS 0.940000
hsa-miR-3686 tgcttttaaTTACAGATtt
 11
 AUCUGUAA m8a (m8a->m7a) -0.211000 no TS 4.230000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.169084796C>A COSN5527518 RK312_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376a-5p agggtcactAATCTAaagt
 0 GUAGAUUC m6b Created no TS -0.040000 No effect
hsa-miR-4760-5p agggtcactAATCTAAAgt
 2
 UUUAGAUU m8a (m7a->m8a) -0.036000 -0.177000 No effect
hsa-miR-921 agggTCACTAatctaaagt
 0 CUAGUGAG m6b Created no TS -0.107000 -0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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