SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002392
Gene Symbol: MDM2
Description: Homo sapiens Mdm2 p53 binding protein homolog (mouse) (MDM2), transcript variant MDM2, mRNA.
Gene Location: chr12(+):69201970-69239212
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.68840170A>T COSN1582519 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4432 ttgagaccGAGTCTTgctc
 1
 AAAGACUC m7b Disrupted -0.103000 -0.035000 No effect
hsa-miR-4462 ttgagaCCGTGTCttgctc
 0 UGACACGG m7b Created no TS -0.282000 No effect
hsa-miR-4432 ttgagaccGAGTCTTgctc
 0 AAAGACUC m7b Disrupted -0.103 -0.035 No effect
hsa-miR-4462 ttgagaCCGTGTCttgctc
 0 UGACACGG m7b Created no TS -0.282 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68840321C>T ICGC_8677193A-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548a-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548ab ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA 0.01
hsa-miR-548ak ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548am-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548ap-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548ar-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548as-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548au-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548av-5p ttttttGTACTTTTagtag
 2
 AAAAGUAC m8a Disrupted -0.117 no TS 0.01
hsa-miR-548b-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA 0.04
hsa-miR-548c-3p ttttttgtATTTTTagtag
 0 CAAAAAUC m6b Created 1.244 1.382 No effect
hsa-miR-548c-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548d-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548h-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548i ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548j ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548k ttttttGTACTTTTagtag
 2
 AAAAGUAC m8a Disrupted -0.117 no TS No effect
hsa-miR-548l ttttttgTACTTTTagtag
 0 AAAAGUAU m7a Disrupted -0.088 -0.088 No effect
hsa-miR-548n ttttttgTACTTTTagtag
 2
 CAAAAGUA m7b Disrupted 0.158 0.144 0.01
hsa-miR-548o-5p ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548t-5p ttttttgtACTTTTagtag
 0 CAAAAGUG m6b Disrupted 0.238 0.178 No effect
hsa-miR-548w ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect
hsa-miR-548y ttttttgTACTTTTagtag
 0 AAAAGUAA m7a Disrupted NA NA No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68840922G>T COSN9474242 AOCS-001-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3616-5p cggctCACTTCAacttccg
 0 AUGAAGUG m7b Created no TS -0.002000 -0.360000
hsa-miR-4795-5p cggctCACTTCaacttccg
 0 AGAAGUGG m6b Created no TS 0.039000 -0.010000
hsa-miR-573 cggctCACTTCAacttccg
 0 CUGAAGUG m7b Created no TS 0.008000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68841030A>G ICGC_AAA0278E-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4684-5p tttttaGTAGAGAcagggt
 0 CUCUCUAC m7b Created -0.242 -0.288 -0.25
hsa-miR-511 tttttagtAAAGACAgggt
 0 GUGUCUUU m7b Disrupted 0.191 0.144 0.01

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68841109A>G ICGC_86771E08-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-338-3p cctcccaaaATGCTGGgat
 0 UCCAGCAU m7b (m7b->m6c) -0.1 -0.055 No effect
hsa-miR-4310 cctcccaaAATGCTGggat
 0 GCAGCAUU m7b Disrupted -0.087 -0.146 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68841570G>- ICGC_518581 TCGA-D5-6930-01A-11D-1924-10 ColonAdenocarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1290 aaaAAAATCCtttatggga
 0 UGGAUUUU m7b (m7b->m6b) 0.042000 no TS 3.620000
hsa-miR-541-5p aaaaaAATCCTTTatggga
 2
 AAAGGAUU m8a Disrupted -0.201000 -0.179000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842003A>C COSN5951064 RK150_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3610 aaggtgtTCCGATTgtata
 0 GAAUCGGA m7b Created no TS -0.107000 No effect
hsa-miR-4539 aaggtGTTCAGattgtata
 3
 GCUGAACU m6b Disrupted -0.056000 -0.085000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842217C>A COSN5951065 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1256 aaacaAATGCCaagctata
 2
 AGGCAUUG m6b Disrupted 0.004000 no TS 0.620000
hsa-miR-4453 aaacaaatgCCAAGCTata
 2
 GAGCUUGG m7b (m7b->m6c) -0.172000 -0.083000 1.200000
hsa-miR-4538 aaacaaatgCCAAGCTata
 2
 GAGCUUGG m7b (m7b->m6c) -0.184000 -0.095000 0.030000
hsa-miR-4642 aaacaaATGCCAagctata
 2
 AUGGCAUC m6b Disrupted -0.008000 no TS 6.120000
hsa-miR-579 aaaCAAATGAcaagctata
 0 UUCAUUUG m7b (m6b->m7b) 0.115000 0.200000 -0.010000
hsa-miR-616-3p aaacaAATGACaagctata
 1
 AGUCAUUG m6b Created 0.111000 0.151000 No effect
hsa-miR-644b-3p aaaCAAATGAcaagctata
 0 UUCAUUUG m7b (m6b->m7b) 0.115000 0.200000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842498G>C COSN7378806 8031073 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842543A>G COSN5326599 RK104_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-656 acagATAATATggatgttt
 1
 AAUAUUAU m7b Disrupted 0.618000 0.402000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842743A>G COSN9754418 C0035T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4287 tattatagAAGGGAGgata
 2
 UCUCCCUU m7b Disrupted -0.062000 -0.050000 0.890000
hsa-miR-4685-3p tattatagAAGGGAGgata
 2
 UCUCCCUU m7b Disrupted -0.053000 -0.050000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842860T>G COSN1582520 RK148_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-410 ggccTTATATaatgaagcc
 1
 AAUAUAAC m6b Disrupted 0.413000 0.233000 No effect
hsa-miR-4528 ggccttaTATAATGAagcc
 1
 UCAUUAUA m8a Disrupted 0.443000 0.267000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68842995T>A COSN9474243 AOCS-079-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3545-3p actaAGTTCAAacttgtca
 0 UUGAACUG m7a Created no TS 0.051000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68844081T>G COSN1582521 RK007_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-513a-3p tacaAAATTTAaatctgca
 2
 UAAAUUUC m7a Disrupted 0.392000 0.184000 No effect
hsa-miR-513c-3p tacaAAATTTAaatctgca
 2
 UAAAUUUC m7a Disrupted 0.392000 0.184000 No effect
hsa-miR-513a-3p tacaAAATTTAaatctgca
 2
 UAAAUUUC m7a Disrupted 0.392 0.184 No effect
hsa-miR-513c-3p tacaAAATTTAaatctgca
 2
 UAAAUUUC m7a Disrupted 0.392 0.184 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68844820A>G ICGC_D315B5B2-2A78-11E2-951E-21FD496BB9B8 CPCG_0103_Pr_P_P5 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273g-3p ggctggagtGCAGTGGTgc
 0 ACCACUGC m8a (m7b->m8a) -0.341 -0.566 -0.02
hsa-miR-4793-3p ggctggAGTGCAGtggtgc
 0 UCUGCACU m7b Created -0.126 -0.143 No effect
hsa-miR-508-5p ggCTGGAGTAcagtggtgc
 1
 UACUCCAG m8a (m8a->m7a) -0.205 -0.097 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68844929C>T COSN5186853 SS6003113 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374b-3p accacgccCTGCTAAtttt
 1
 CUUAGCAG m7b Created -0.041000 -0.089000 -0.140000
hsa-miR-4524a-5p accacgccCTGCTAatttt
 1
 AUAGCAGC m6b Created -0.007000 -0.078000 -0.010000
hsa-miR-4524b-5p accacgccCTGCTAatttt
 1
 AUAGCAGC m6b Created -0.004000 -0.075000 -0.010000
hsa-miR-4690-5p accacgcCCTGCTaatttt
 0 GAGCAGGC m6b Created no TS -0.114000 -0.570000
hsa-miR-4706 accacgCCCCGCTaatttt
 0 AGCGGGGA m7a Disrupted NA NA 0.810000
hsa-miR-4781-5p accacgCCCCGCTAatttt
 1
 UAGCGGGG m8a Disrupted -0.435000 no TS 2.740000
hsa-miR-744-5p accacGCCCCGCtaatttt
 1
 UGCGGGGC m7b Disrupted -0.291000 no TS 2.740000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68845024C>T ICGC_867722D6-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1275 gccttggcCCCCCAaagtg
 0 GUGGGGGA m6b Disrupted -0.12 no TS 0.01
hsa-miR-149-3p gccttggCCTCCCaaagtg
 0 AGGGAGGG m6b Created -0.332 -0.433 No effect
hsa-miR-30b-3p gccttggCCTCCCAaagtg
 0 CUGGGAGG m7b Created -0.711 -0.894 -0.01
hsa-miR-30c-1-3p gccttggcCTCCCAaagtg
 0 CUGGGAGA m6b Created -0.258 -0.307 No effect
hsa-miR-30c-2-3p gccttggcCTCCCAaagtg
 0 CUGGGAGA m6b Created -0.273 -0.332 No effect
hsa-miR-3122 gccttggccTCCCAAagtg
 0 GUUGGGAC m6b Created 0.005 -0.019 -0.01
hsa-miR-3689a-3p gccttggCCTCCCAaagtg
 0 CUGGGAGG m7b Created -0.721 -0.914 No effect
hsa-miR-3689b-3p gccttggCCTCCCAaagtg
 0 CUGGGAGG m7b Created -0.721 -0.904 No effect
hsa-miR-3689c gccttggCCTCCCAaagtg
 0 CUGGGAGG m7b Created -0.721 -0.904 No effect
hsa-miR-4260 gccttggccCCCCAAagtg
 0 CUUGGGGC m6b Disrupted -0.059 no TS 0.03
hsa-miR-450a-3p gccttggccCCCCAAagtg
 0 AUUGGGGA m6b Disrupted -0.053 no TS 0.01
hsa-miR-4665-5p gccttggcCCCCCAaagtg
 0 CUGGGGGA m6b Disrupted -0.117 no TS No effect
hsa-miR-4728-5p gccttggCCTCCCAaagtg
 0 UGGGAGGG m7a Created -0.359 -0.46 No effect
hsa-miR-5572 gccttggccCCCCAAagtg
 0 GUUGGGGU m6b Disrupted -0.059 no TS 0.17

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68845037T>G ICGC_867727F4-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-3p aaagTGCTGTGattacagg
 0 CACAGCAA m7a Disrupted -0.414 -0.414 0.01
hsa-miR-34b-3p aaagtgctGTGATTacagg
 0 CAAUCACU m6b Disrupted 0.136 0.102 No effect
hsa-miR-4530 aaagTGCTGGGattacagg
 0 CCCAGCAG m7a Created -0.01 -0.01 No effect
hsa-miR-4733-5p aaagtgcTGGGATTacagg
 0 AAUCCCAA m7a Created NA NA No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.68845195T>G COSN5718619 HX30T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-23a-3p cattttgATGTGATactta
 2
 AUCACAUU m7a Created 0.128000 0.128000 -0.010000
hsa-miR-23b-3p cattttgATGTGATactta
 2
 AUCACAUU m7a Created 0.128000 0.128000 -0.010000
hsa-miR-23c cattttgATGTGATactta
 2
 AUCACAUU m7a Created 0.145000 0.145000 -0.010000
hsa-miR-3671 cattttgATTTGATactta
 3
 AUCAAAUA m7a Disrupted 0.724000 0.724000 0.030000
hsa-miR-4762-5p cattttGATTTGatactta
 1
 CCAAAUCU m6b Disrupted 0.106000 0.170000 0.790000
hsa-miR-551b-5p cattTTGATTTgatactta
 4
 GAAAUCAA m7b Disrupted 0.631000 0.700000 0.050000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
68840827 rs142216873 T T hsa-miR-4282
4
 AAATTTTAgatac
 Disrupted
N
 0.187
A hsa-miR-200a-5p
hsa-miR-200b-5p
hsa-miR-302a-5p
hsa-miR-3606-3p
hsa-miR-513a-3p
hsa-miR-513c-3p
2
2
3
5
5
5
 aaattTAAGATAc
aaattTAAGATAc
aaaTTTAAGAtac
AAATTTAagatac
AAATTTAagatac
AAATTTAagatac
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 0.004
0.004
0.045
0.117
0.124
0.124
68840894 rs36086070 G G hsa-miR-1251-5p
hsa-miR-5684
hsa-miR-7703
1
1
1
 atGCTAGAGtgca
atgCTAGAGTgca
atgctaGAGTGCA
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.056
0.04
-0.038
A hsa-miR-374b-3p
hsa-miR-4325
2
1
 aTGCTAAAgtgca
atgctaAAGTGCA
 Created
Created
N
N
 0.057
-0.041
68840902 rs34897800 T T hsa-miR-1273g-3p
hsa-miR-181a-2-3p
hsa-miR-6509-3p
2
2
2
 gtGCAGTGGAgtg
gtgCAGTGGAgtg
gtgCAGTGGAgtg
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.16
-0.014
-0.015
G hsa-miR-331-3p
hsa-miR-6801-3p
hsa-miR-6810-3p
2
2
2
 gtgCAGGGGAgtg
gtGCAGGGGAgtg
gtGCAGGGGAgtg
 Created
Created
Created
N
N
N
 -0.065
-0.244
-0.223
68841010 rs113162219 - - hsa-miR-1207-3p
hsa-miR-34a-3p
hsa-miR-548c-3p
2
1
0
 CAGCTGAtttttt
caGCTGATTtttt
cagctGATTTTTt
 Unknown
Unknown
Unknown
N
N
N
 0.001
0.003
0.01
T
68841112 rs116933203 C C hsa-miR-338-3p
hsa-miR-4310
hsa-miR-7157-5p
hsa-miR-7977
2
2
2
2
 aaaATGCTGGgat
aaAATGCTGggat
aaAATGCTGggat
aaaatGCTGGGAt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.045
0.059
0.022
-0.063
T hsa-miR-4733-5p
2
 aaaatgTTGGGAT
 Created
N
 0.006
68842268 rs185140075 C C hsa-miR-3140-5p
hsa-miR-4539
1
1
 aaagTTCAGGAca
aaAGTTCAGgaca
 Disrupted
Disrupted
N
N
 0.032
0.019
G hsa-miR-3909
hsa-miR-6852-3p
1
1
 aaagttGAGGACA
aaagttGAGGACA
 Created
Created
N
N
 -0.031
-0.034
68842675 rs191198390 A A hsa-miR-3606-3p
hsa-miR-513a-3p
hsa-miR-513c-3p
1
1
1
 attcaaAAATTTA
attcaaAAATTTA
attcaaAAATTTA
 Disrupted
Disrupted
Disrupted
N
N
N
 0.21
0.207
0.207
T hsa-miR-944
1
 attcAATAATTta
 Created
N
 0.165
68844471 rs141938174 C
T hsa-miR-34b-3p
hsa-miR-4705
hsa-miR-513b-5p
3
3
3
 AGTGATTgtgaat
aGTGATTGtgaat
agtgaTTGTGAAt
 Created
Created
Created
N
N
N
 0.002
-0.028
0.065

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