SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002386
Gene Symbol:	MC1R
Description:	Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R), mRNA.
Gene Location:	chr16(+):89984286-89987385
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.89920464G>A			8_1574		667720		Myeloid leukemia
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-188-3p	ggtTGTGGGAcctcaggct	6	CUCCCACA	m7b	(m6b->m7b)	no TS	-0.085	-1.43
hsa-miR-4433-5p	ggttGTGGGACctcaggct	6	CGUCCCAC	m7b	Created	-0.101	-0.288	-1.13
hsa-miR-4758-3p	ggttGTGGGGCctcaggct	6	UGCCCCAC	m7b	Disrupted	-0.208	no TS	2.86
hsa-miR-5008-5p	ggttgtgGGGCCTCAggct	5	UGAGGCCC	m8a	Disrupted	-0.73	-0.398	0.75

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.89920872C>A			COSN1192653		BN04T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1228-5p	tgcagcagtCGCCCAagca	1	GUGGGCGG	m6b	Disrupted	-0.527000	-0.315000	0.730000
hsa-miR-1273a	tgcagcaGTCGCCCaagca	0	GGGCGACA	m7a	Disrupted	NA	NA	2.450000
hsa-miR-4649-5p	tgcagcagTCGCCCAagca	1	UGGGCGAG	m7a	Disrupted	-0.230000	no TS	4.600000
hsa-miR-4674	tgcagcagtAGCCCAagca	0	CUGGGCUC	m6b	Created	no TS	-0.127000	-12.410000
hsa-miR-644b-5p	tgcagcagTAGCCCAagca	0	UGGGCUAA	m7a	Created	no TS	-0.176000	-6.190000
hsa-miR-1228-5p	tgcagcagtCGCCCAagca	1	GUGGGCGG	m6b	Disrupted	-0.527000	-0.315000	0.730000
hsa-miR-1273a	tgcagcaGTCGCCCaagca	0	GGGCGACA	m7a	Disrupted	NA	NA	2.450000
hsa-miR-4649-5p	tgcagcagTCGCCCAagca	1	UGGGCGAG	m7a	Disrupted	-0.230000	no TS	4.600000
hsa-miR-4674	tgcagcagtAGCCCAagca	0	CUGGGCUC	m6b	Created	no TS	-0.127000	-12.410000
hsa-miR-644b-5p	tgcagcagTAGCCCAagca	0	UGGGCUAA	m7a	Created	no TS	-0.176000	-6.190000
hsa-miR-1228-5p	tgcagcagtCGCCCAagca	0	GUGGGCGG	m6b	Disrupted	-0.527	-0.315	0.73
hsa-miR-1273a	tgcagcaGTCGCCCaagca	0	GGGCGACA	m7a	Disrupted	NA	NA	2.45
hsa-miR-4649-5p	tgcagcagTCGCCCAagca	0	UGGGCGAG	m7a	Disrupted	-0.23	no TS	4.6
hsa-miR-4674	tgcagcagtAGCCCAagca	0	CUGGGCUC	m6b	Created	no TS	-0.127	-12.41
hsa-miR-644b-5p	tgcagcagTAGCCCAagca	0	UGGGCUAA	m7a	Created	no TS	-0.176	-6.19

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
89920519	rs138058610	G	G	hsa-miR-1228-5p	1	ttttCCGCCCAct	Disrupted	N	-0.315
			A	hsa-miR-1293 hsa-miR-3148 hsa-miR-363-5p hsa-miR-4483 hsa-miR-6124 hsa-miR-6745 hsa-miR-6748-5p hsa-miR-6756-5p hsa-miR-6766-5p	1 1 1 1 1 1 1 1 1	ttttCCACCCAct TTTTCCAcccact tttTCCACCCAct ttttCCACCCAct TTTTCCAcccact tttTCCACCCAct ttttcCACCCACt ttttCCACCCAct ttttCCACCCAct	Created Created Created Created Created Created Created Created Created	N N N N N N N N N	-0.16 0.062 -0.399 -0.167 0.043 -0.42 -0.16 -0.13 -0.144
89920793	rs3212371	G	A	hsa-miR-1255b-2-3p hsa-miR-3189-5p	0	AGTGGTAtggggc agtggtATGGGGC	Created Created	N N	-0.077 -0.177
			G	hsa-miR-4758-3p	3	agtggtGTGGGGC	Disrupted	N	-0.206

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